CAS 2581-34-2 MFCD00007333-3-Methyl-4-nitrophenol 3-甲基-4-硝基苯酚 TAO{mole}

3-Methyl-4-nitrophenol 3-甲基-4-硝基苯酚

CAS 2581-34-2 MFCD00007333

化学结构图

SMILES: Cc1cc(O)ccc1[N+](=O)[O-]

化学属性

Mol. Formula	C7H7NO3
Mol. Weight	153.14
Melting Point	125-130°C
Density	1.422
TSCA	Yes
Flash Point	110℃
Appearance	针状或柱状黄色结晶。遇空气、光照也不变色。熔点128-129℃，沸点200℃（分解），闪点110℃，着火点455℃。极易溶于乙醇、乙醚、氯仿和苯，难溶于冷水。其钠盐和钾盐都是含2分子结晶水的黄色叶状晶体。
Boiling Point	304.8°C at 760 mmHg
Solubility	极易溶于乙醇、乙醚、氯仿和苯。难溶于冷水。

别名和识别编码

Chemical Name	3-Methyl-4-Nitrophenol
CAS Number	2581-34-2
Alfabeta Name	METHYLNITROPHENOL 34---
MDL Number	MFCD00007333
Synonym	3-Methyl-4-nitrophenol {LY} 3-Methyl-4-nitrophenol 3-methyl-4-nitrophenol 4-nitro-3-cresol 4-nitro-3-cresol, sodium salt p-nitro-m-cresol {} {LY} 3-Methyl-4-nitrophenol {} {} {LY} 3-Methyl-4-nitrophenol {} {} {} {LY} 3-Methyl-4-nitrophenol {} {} {} {} {LY} 3-Methyl-4-nitrophenol {} {} {} {} {} {LY} 3-Methyl-4-nitrophenol {} {} {} {} {} {} {LY} 3-Methyl-4-nitrophenol {} {} {} {} {} {} {} {LY} 3-Methyl-4-nitrophenol {} {} {} {} {} {} {} {} {LY} 3-Methyl-4-nitrophenol {} {} {} {} {} {} {} {} {} {LY} 3-Methyl-4-nitrophenol {} {} {} {} {} {} {} {} {} {} {LY} 3-Methyl-4-nitrophenol {} {} {} {} {} {} {} {} {} {} {} {LY} 3-Methyl-4-nitrophenol {} {} {} {} {} {} {} {} {} {} {} {} {LY} 3-Methyl-4-nitrophenol {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 3-Methyl-4-nitrophenol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 3-Methyl-4-nitrophenol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
EC Number	219-952-5
Beilstein Registry Number	1868105
PubChem Substance ID	17412
Chemical Name Translation	3-甲基-4-硝基苯酚
Reaxys-RN	1868105
Wiswesser Line Notation	WNR DQ B1
LabNetwork Molecule ID	LN00173742
InChI	InChI=1S/C7H7NO3/c1-5-4-6(9)2-3-7(5)8(10)11/h2-4,9H,1H3
Canonical SMILES	OC1=CC=C([N+]([O-])=O)C(C)=C1

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品牌质保精细包装现货库存一流品牌服务

安全信息

Warnings IRRITANT

Signal word Warning

GHS Symbol

WGK Germany3

Safety Statements

S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；

Risk Statements

R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
R22 Harmful if swallowed 吞咽有害
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P203
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P264+P265
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P301+P312
P301+P312+P330
P301+P317
P302+P352
P302+P352+P332+P313+P362+P364
P304+P312
P304+P340
P305+P351+P338
P305+P351+P338+P337+P313
P305+P354+P338
P308+P313
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P317
P318
P319
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P332+P313
P332+P317
P337+P313
P337+P317
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P362+P364
P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P403+P233
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

RTECSGP2625000

Hazard statements

H302 Harmful if swallowed 吞食有害
H312 Harmful in contact with skin 皮肤接触有害
H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H332 Harmful if inhaled 吸入有害
H335 May cause respiratory irritation 可能导致呼吸道刺激

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes 6.1 Xn

UN Number 2446 UN 2446 6.1/PG 3

Packing GroupIII

Hazard Class6.1

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intracerebral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 15 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCBPBS Pesticide Biochemistry and Physiology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.1-    1971-  Volume(issue)/page/year:
   8,302,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAFCAU Journal of Agricultural and Food Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
   20037)  V.1-    1953-  Volume(issue)/page/year: 27,1054,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 90 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCBPBS Pesticide Biochemistry and Physiology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.1-    1971-  Volume(issue)/page/year:
   8,302,1978

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 2500 mg/kg/10W (Intermittent)
REFERENCE :
   EESADV Ecotoxicology and Environmental Safety.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.1-    1977-  Volume(issue)/page/year:
   9,47,1985

Storage condition RT, stored under nitrogen {LY} RT, stored under nitrogen {} {LY} RT, stored under nitrogen {} {} {LY} RT, stored under nitrogen {} {} {} {LY} RT, stored under nitrogen {} {} {} {} {LY} RT, stored under nitrogen {} {} {} {} {} {LY} RT, stored under nitrogen {} {} {} {} {} {} {LY} RT, stored under nitrogen {} {} {} {} {} {} {} {LY} RT, stored under nitrogen {} {} {} {} {} {} {} {} {LY} RT, stored under nitrogen {} {} {} {} {} {} {} {} {} {LY} RT, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {LY} RT, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {LY} RT, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

其他信息

方法一:对硝基间甲酚的制备方法有亚硝化氧化法和一步硝化法。因一步硝化法耗酚量较大，成本较高，故工业上采用亚硝化氧化法。反应方程式见图在亚硝化釜中加入预先配制好的稀硝酸，在强搅拌及低温下滴加问甲酚及亚硝酸钠混合液。加完后保持低温反应一定时间，将物料放入氧化釜内缓缓升温进行氧化。用Na 2 CO 3 液吸收大量放出的NO x ，当氧化釜内温度升到47℃时，NO x 释放殆净，降温到25℃以下，放入离心机进行离心分离，得到粗品4-硝。计量分析后加入精制釜内，经甲苯升温溶解，低温结晶后，再在防爆离心机中进行分离，即得到精4-硝。
4-硝基间甲苯酚价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 N0351 4-硝基间甲酚 4-Nitro-m-cresol 25G 347元 2014/06/02 N0351 4-硝基间甲酚 4-Nitro-m-cresol 500G 2130元 2010/06/21 127301000 4-硝基间甲苯酚 3-Methyl-4-nitrophenol 98% 100 GR 945元
用途一:用作医药中间体
方法二:以间甲酚为原料，可用亚硝化氧化法或直接硝化法制取。1.盐酸亚硝化氧化法将间甲酚与15%盐酸、亚硝酸钠、氢氧化钠在反应温度（0±3）℃下进行反应，制得亚硝基化合物。再在38%硝酸中于（40±2）℃时进行氧化，即得。产率87%。2.硝酸一步法将间甲酚滴加于-5～0℃的20%硝酸和40%亚硝酸钠溶液中，搅拌10分钟后，升温至30℃并保温2h，即得。产率99%。另外还有一种称为羟基保护硝化的方法。
Alfa Aesar:3-甲基-4-硝基苯酚,98% 3-Methyl-4-nitrophenol, 98%(2581-34-2)
用途二:对硝基间甲酚又称3-甲基-4-硝基苯酚(3-methyl-4-nitrophenol)，简称4-硝，是有机磷杀虫剂杀螟硫磷的中间体。
Sigma Aldrich:2581-34-2(sigmaaldrich)
上游原料:硝酸 --> 间甲酚 --> 盐酸亚
MOL 文件:2581-34-2.mol
图谱信息:4-硝基间甲苯酚(2581-34-2)核磁图( 1 HNMR) 4-硝基间甲苯酚(2581-34-2)质谱(MS) 4-硝基间甲苯酚(2581-34-2)红外图谱(IR2) 4-硝基间甲苯酚(2581-34-2)Raman光谱 4-硝基间甲苯酚(2581-34-2)核磁图( 13 CNMR) 4-硝基间甲苯酚(2581-34-2)红外图谱(IR1)
TCI Shanghai:4-硝基间甲基苯酚 4-Nitro-m-cresol,>;98.0%(GC)(T)(2581-34-2)
用途三:用途较广，主要用来制造农药杀螟松（一种高效、低毒、低残留的优良有机磷杀虫剂）。
下游产品:杀螟松 --> 2-甲基-4-甲氧基苯胺 --> 5-甲氧基-1H-吲唑 --> 5-甲氧基-2-硝基苯甲酸 --> 5-羟基吲哚 --> 3-甲基-4-硝基苯甲醚
Acros Organics:3-甲基-4-硝基苯酚 3-Methyl-4-nitrophenol, 98%(2581-34-2)
MSDS 信息:3-Methyl-4-nitrophenol(2581-34-2).msds
海关编码:29089000