CAS 57-14-7 MFCD00007628-1,1-Dimethylhydrazine 1,1-二甲基肼 TAO{mole}

1,1-Dimethylhydrazine 1,1-二甲基肼

CAS 57-14-7 MFCD00007628

化学结构图

SMILES: CN(C)N

化学属性

Mol. Formula	C2H8N2
Mol. Weight	60.12
Refractive index	n20/D 1.4075(lit.)
Boiling Point	60-62 °C(lit.)
Density	0.79 g/mL at 20 °C(lit.)
Autoignition Point	478 °F
Vapor Density	1.94 (vs air)
Vapor Pressure	103 mmHg ( 20 °C)
Flash Point	-18 ºC
Melting Point	-57.2 ºC
Solubility	MISCIBLE

别名和识别编码

Chemical Name	Hydrazine, 1,1-dimethyl-
Synonym	(CH3)2NNH2 1,1-DIMETHYLHYDRAZINE 1,1-Dimethylhydrazin 1,1-Dimethylhydrazine 1,1-dimethyhydrazine 1,1-dimethyl 1,1-dimethyl-hydrazin 1,1-dimethyl-hydrazine 1,1-dimethylhydrazine 1,1-二甲基肼 1,1-二甲肼 1，1-二甲基肼 ASYM-DIMETHYLHYDRAZINE Dimazin Dimazine Dimethyl hydrazine(unsymmetrical) Dimethylhydrazin, asymmetrisch Dimethylhydrazine Hydrazine, N,N-dimethyl- N,N-DIMETHYLHYDRAZINE N,N-DIMETHYLHYDRAZINE(ASYM) N,N-Dimethylhydrazin (asym.) N,N-Dimethylhydrazine N,N-dimethyl-hydrazine N,N-dimethylhydrazine N,N-dimethylhydrazine (asym.) anhydrous N,N-二甲基肼 N1,N1-Dimethylhydrazin Niesymetryc
CAS Number	57-14-7
PubChem Substance ID	5976
EC Number	200-316-0
Beilstein Registry Number	0605261
MDL Number	MFCD00007628
Chemical Name Translation	1,1-二甲基肼
Merck Number	14,3247
Wiswesser Line Notation	ZN1&1
InChI	InChI=1S/C2H8N2/c1-4(2)3/h3H2,1-2H3

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安全信息

GHS Symbol

WGK Germany3

Hazard Codes F;T;N F,T,N

Hazard statements

H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
H301 Toxic if swallowed 吞食有毒
H311 Toxic in contact with skin 皮肤接触中毒
H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
H331 Toxic if inhaled 吸入中毒
H335 May cause respiratory irritation 可能导致呼吸道刺激
H350 May cause cancer 可能致癌
H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。

Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US)

RTECSMV2450000

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P233 Keep container tightly closed. ?保持容器密闭。
P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
P242 Use only non-sparking tools. 只能使用无火花工具。
P243 Take precautionary measures against static discharge. 采取预防措施，防止静电放电。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P284 Wear respiratory protection.? 佩戴呼吸保护装置。
P301+P310
P301+P330+P331
P302+P352
P303+P361+P353
P304+P340
P305+P351+P338
P307+P311
P308+P313
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
P320 Specific treatment is urgent (see … on this label). 紧急具体治疗（见本标签上的）。
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P332+P313
P337+P313
P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
P370+P378
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P403+P233
P403+P235
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word Danger

Safety Statements

S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；

Risk Statements

R11 Highly flammable 非常易燃
R51/53
R45 May cause cancer 可能致癌
R23/25 Toxic by inhalation and if swallowed 吸入及吞食都有毒
R34 Causes burns 会导致灼伤

UN Number 1163 UN 1163 6.1/PG 1

Packing GroupI

Hazard Class6.1

Storage condition 2-8°C

Restrict 剧毒化学品

Warnings 危化品目录(2015) 危险化学品

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5880 mg/kg/42W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Vascular - tumors
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher informatio

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 288 mg/kg/8W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   42,337,1969

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 2686 mg/kg/72W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Peripheral Nerve and Sensation - peripheral nerve tumors
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   35,303,1

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 400 mg/kg/20W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Gastrointestinal - tumors
   Gastrointestinal - colon tumors
REFERENCE :
   SUFOAX Surgical Forum.  (American College of Surgeons, 55 E. Erie St.,
   Chicago, IL 60611) V.1-    1950-  Volume(issue)/page/year: 31,413,1980

TYPE

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 172 ppm/4H
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   AMIHAB AMA Archives of Industrial Health.  (Chicago, IL)  V.11-21, 1955-60.
   For publisher information, see AEHLAU.  Volume(issue)/page/year: 12,609,1955

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 122 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MEPAAX Medycyna Pracy.  Industrial Medicine.  (Ars-Polona, POB 1001, 00-068
   Warsaw 1, Poland) V.1-    1950-  Volume(issue)/page/year: 24,71,1973

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intracerebral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 27 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   14,1901,1965

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 392 ppm/4H
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   AMIHAB AMA Archives of Industrial Health.  (Chicago, IL)  V.11-21, 1955-60.
   For publisher information, see AEHLAU.  Volume(issue)/page/year: 12,609,1955

TYPE OF TEST            : LC50 - Lethal concentration,

{hazard

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - mouse Ascites tumor
DOSE/DURATION           : 900 umol/L
REFERENCE :
   JJATDK JAT, Journal of Applied Toxicology.  (John Wiley &

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Ascites tumor
DOSE/DURATION           : 1100 umol/L
REFERENCE :
   JJATDK JAT, Journal of Applied Toxicology.  (John Wiley & Sons Ltd., Baffins
   Lane, Chichester, W. Sussex PO19 1UD, UK)  V.1-    1981-
   Volume(issue)/page/year: 1,243,1981

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 42 umol/plate
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   41,1469,1981

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Rodent - mouse Liver
DOSE/DURATION           : 100 umol/L
REFERENCE :
   JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB
   211, 1000 AE Amsterdam, Netherlands)  V.76-    1985-
   Volume(issue)/page/year: 79,204,1988

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 167 umol/L
REFERENCE :
   PNASA6 Proceedings of the National Academy of Sciences of the United States
   of America.  (National Academy of Sciences, Printing & Pub. Office, 2101
   Constitution Ave., Washington, DC 20418) V.1-    1915-
   Volume(issue)/page/year: 80,7219,1983

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 300 umol/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 7,267,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 600 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(issue)/page/year: 13,125,1984

其他信息

下游产品:萎蔫酸 --> 5-丁基吡啶-2-甲腈 --> 二甲基肼吡啶 --> 丁酰肼
方法二:本品可以氨水、氯化胺和二甲胺为原料经反应合成制得。先将氨水和次氯酸钠分别送入一步反应器进行反应生成氯代胺，然后将氯代胺送入二步反应器与二甲胺水溶液进行合成，生成偏二甲肼水溶液，再将此合成液送入一系列精馏塔进一步蒸馏精馏，脱除过量的氨、二甲胺和偏腙，加碱提浓、脱气后，即得成品。
灭火剂:干粉、干砂、二氧化碳、泡沫、1211灭火剂
爆炸物危险特性:与空气混合可爆
检测方法:GC,NMR
蒸气压:103 mm Hg ( 20 °C)
用途一:用作燃料添加剂及用于有机合成
职业标准:TWA 1 毫克/ 立方米; STEL 0.25 毫克/ 立方米
图谱信息:1,1-二甲基肼(57-14-7)核磁图( 13 CNMR) 1,1-二甲基肼(57-14-7)质谱(MS) 1,1-二甲基肼(57-14-7)Raman光谱 1,1-二甲基肼(57-14-7)红外图谱(IR1)
外观性质:无色带有氨气味的液体, 具有吸湿性。
类别:易燃液体
可燃性危险特性:遇明火、高温、氧化剂易燃; 遇热分解有毒氧化氮气体
敏感性:Hygroscopic
用途三:该品用于生产植物生长调节剂，其苯酚盐可减少润滑盐的沉积现象。还可用于吸收酸性气体，也可用作高能原料。
上游原料:次氯酸钠 --> 二甲胺 --> 氯酸钠 --> 次氯酸 --> 二苯甲酮腙 --> 二甲胺水溶液 --> 氯化胺
MOL 文件:57-14-7.mol
Sigma Aldrich:57-14-7(sigmaaldrich)
急性毒性:口服- 大鼠 LD50: 122 毫克/ 公斤; 口服- 小鼠 LD50: 265 毫克/ 公斤
毒性分级:高毒
蒸气密度:1.94 (vs air)
储运特性:库房通风低温干燥; 与氧化剂、酸类分开存放
用途二:N，N-二甲基肼又称偏二甲基肼，是植物生长调节剂丁酰肼的中间体。
海关编码:29280090
方法一:其制备方法是以氨与次氯酸钠反应生成NH 2 Cl，然后与二甲胺反应即可得到产品。反应方程式：NH 3 +NaOCl→NH 2 Cl[HN(CH 3 ) 2 ]→H 2 NN(CH 3 ) 2
MSDS 信息:1,1-二甲基肼(57-14-7).msds