CAS 95-51-2 MFCD00007656-2-Chloroaniline 2-氯苯胺 TAO{mole}

2-Chloroaniline 2-氯苯胺

CAS 95-51-2 MFCD00007656

化学结构图

SMILES: Nc1ccccc1Cl

化学属性

Mol. Formula	C6H6ClN
Mol. Weight	127.57
Boiling Point	208-210
Density	1.213
Refractive index	1.5870 to 1.5910
Flash Point	104°C(lit.)
TSCA	Yes
Melting Point	0-3
Solubility	5.13 G/L (20 ºC)
Stability	对光敏感
pH	:A

别名和识别编码

Chemical Name	2-Chloroaniline
CAS Number	95-51-2
PubChem Substance ID	7240
EC Number	202-426-4
Beilstein Registry Number	606077
MDL Number	MFCD00007656
Reaxys-RN	606077
Merck Number	2118
Synonym	Aniline, o-chloro- {LY} Aniline, o-chloro- {} {LY} Aniline, o-chloro- {} {} {LY} Aniline, o-chloro- {} {} {} {LY} Aniline, o-chloro- {} {} {} {} {LY} Aniline, o-chloro- {} {} {} {} {} {LY} Aniline, o-chloro- {} {} {} {} {} {} {LY} Aniline, o-chloro- {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Aniline, o-chloro- {} {} {} {} {} {} {} {} {LY} Aniline, o-chloro- {} {} {} {} {} {} {} {} {} {LY} Aniline, o-chloro- {} {} {} {} {} {} {} {} {} {} {LY} Aniline, o-chloro- {} {} {} {} {} {} {} {} {} {} {} {LY} Aniline, o-chloro- {} {} {} {} {} {} {} {} {} {} {} {} {LY} Aniline, o-chloro- {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Aniline, o-chloro- {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Aniline, o-chloro- {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Aniline, o-chloro- {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Aniline, o-chloro- {} {} {} {} {} {} {} {} {} {}
Chemical Name Translation	2-氯苯胺
Wiswesser Line Notation	ZR BG
LabNetwork Molecule ID	LN00224199
InChI	InChI=1S/C6H6ClN/c7-5-3-1-2-4-6(5)8/h1-4H,8H2
Canonical SMILES	NC1=CC=CC=C1Cl

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品牌质保精细包装现货库存一流品牌服务

产品应用

用作染料中间体、溶剂、防霉剂及试剂。

安全信息

GHS Symbol

WGK Germany3

Hazard statements

H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
H331 Toxic if inhaled 吸入中毒
H311 Toxic in contact with skin 皮肤接触中毒
H301 Toxic if swallowed 吞食有毒
H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
H302+H332
H301+H311+H331

Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

Hazard Codes 6.1 F,T T,N T,N,F

RTECSBX0525000

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P310
P301+P312+P330
P302+P350
P305+P351+P338
P308+P313
P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
P337+P313
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word Danger

UN Number 2019 UN 2019 6.1/PG 2

Risk Statements

R11 Highly flammable 非常易燃
R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
R33 Danger of cumulative effects 有累积作用的危险
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性：吸入，皮肤接触和吞食都会产生十分严重的不可逆危险
R50/53

Safety Statements

S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；

Packing GroupII

Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

Hazard Class6.1

Warnings 危化品目录(2015)

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 310 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory depression
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   AHBAAM Archiv fuer Hygiene und Bakteriologie.  (Munich, Fed. Rep. Ger.)
   V.101-154, 1929-71.  For publisher information, see ZHPMAT.
   Volume(issue)/page/year: 110,12,1933

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 222 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 13(5),29,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 256 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 13(5),29,1969

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Mold - Aspergillus nidulans
DOSE/DURATION           : 200 mg/L
REFERENCE :
   CJMIAZ Canadian Journal of Microbiology.  (National Research Council of
   Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.1- 
     1954-  Volume(issue)/page/year: 16,369,1970

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 600 ug/L
REFERENCE :
   BLFSBY Basic Life Sciences.  (Plenum Pub. Corp., 223 Spring St., New York,
   NY 10003)  V.1-    1973-  Volume(issue)/page/year: 39,359,1986

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 500 ug/L
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 62,873,1979

TYPE OF TEST            : Specific locus test
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 300 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   17,196,1991

Restrict 危险品

其他信息

用途一:用作
下游产品:邻二氯苯 --> 1,3-二氯苯 --> 氯磺隆 --> 4-（2-酮酸-1-苯并咪唑）哌啶 --> 2-二环己膦基-2'-(N,N-二甲胺)-联苯 --> 邻氯苯磺酰胺 --> 邻氨基苯乙醚 --> 8-氯喹啉 --> 草除灵 --> 2-溴氯苯 --> 4-溴-2-氯乙酰苯胺 --> 2'-氯-N-乙酰乙酰苯胺 --> 洗衣粉增白剂 JD-3,4,4'-双-(6-邻氯苯胺基-4-羟乙基胺基-1,3,5-三嗪2-氨基)-二苯乙烯 2,2'-二磺酸钠 --> N-(2,5-二甲氧基苯基)-2-羟基二苯并呋喃-3-甲酰胺 --> 邻氯苯基硫脲 --> 邻氯苯异氰酸酯 --> 敌菌灵 --> 邻氯苯胺盐酸盐 --> 2-氯苯磺酰氯 --> 4,4'-二氨基-3,3'-二氯二苯甲烷 --> 活性红24 --> N-(2-氯苯基)乙酰胺
Sigma Aldrich:95-51-2(sigmaaldrich)
Acros Organics:2-氯苯胺 2-Chloroaniline, 98+%
防护措施:剧毒。吞咽、吸入蒸气或经皮肤吸收均会引起中毒。具有溶血性并能引起膀胱癌。操作时应避免吸入蒸气，防止与皮肤接触。生产设备应密闭，防止泄漏。生产现场应保持良好通风。操作人员应穿戴防护用具。
常规方法:用清洁、干燥的铁桶包装，每桶220kg。容器密封，防止暴露在空气中。避免与食物容器共同贮运。按剧毒化学品规定贮运。
用途二:用作染料中间体，也用于有机合成
急性毒性:口服- 小鼠 LD50: 256 毫克/ 公斤
外观性质:琥珀色液体，有氨臭。
类别:有毒物品
方法一:其制备方法是用邻氯硝基苯与铁屑、稀盐酸和水回流6～8h，蒸馏得粗品，再蒸馏得成品。或者用催化加氢的方法，也就是以邻氯硝基苯为原料，在催化剂存在下加氢而制得成品。
可燃性危险特性:明火可燃; 高热放出有毒氯化物及氮氧化物气体
方法二:由邻硝基氯苯还原而得：在盐酸介质中用铁粉还原，回流6-8h，经水蒸汽蒸馏、减压蒸馏得成品。也可以在甲酸存在下进行铁粉还原：在10m3的铸铁还原釜中加入2m3沸水，然后加入邻硝基氯苯100kg、甲酸15kg、铁粉1.5t，进行还原反应。在17-20h内分次加入4t邻硝基氯苯。其间，在还原反应进行到一刻钟时，加入1t邻硝基氯苯，同时加入铁粉1.5t和甲酸15kg。如果反应缓慢，可再加入铁粉1t。反应完成后，静置，分离出胺层，再静置，使铁沉淀，铁渣用水蒸汽蒸馏出胺。将粗品减压蒸馏，得邻氯苯胺3160kg，收率95%。原料消耗定额：邻硝基氯苯1300kg/t、铁粉（90%）1450kg/t、盐酸（37%） 380kg/t。
有氨臭.在空气中稳定，暴露在空气中颜色变黑, 不溶于水，溶于乙醇、乙醚和大多数有机溶剂。
Alfa Aesar:2-氯苯胺,98+% 2-Chloroaniline, 98+%(95-51-2)
MSDS 信息:邻氯苯胺(95-51-2).msds
用途四:该品为冰染染料色基，亦可作为偶氮染料的重氮组分，用于生产酸性黑、酸性蓝及有机色淀水固黄R、永固红FR、汉沙黄HR等。并可用于制取医药、农药、聚氨酯树脂的交联剂甲基双氯苯胺。
图谱信息:2-氯苯胺(95-51-2)红外图谱(IR2) 2-氯苯胺(95-51-2)核磁图( 13 CNMR) 2-氯苯胺(95-51-2)红外图谱(IR1) 2-氯苯胺(95-51-2)核磁图( 1 HNMR) 2-氯苯胺(95-51-2)质谱(MS)
2-氯苯胺价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 80032326 邻氯苯胺 100ml 18.9元 2011/04/16 C0111 2-氯苯胺 2-Chloroaniline 25ML 156元 201
用途五:用作染料中间体
海关编码:29214210
用途五:用作染料中间体、溶剂、防霉剂及试剂。
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