3,4-Dichloroaniline 3,4-二氯苯胺
CAS 95-76-1 MFCD00007768
信息真实价格透明
资金保障
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信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- {Chemicalbook} 农药中间体: 除草剂中间体: 取代脲类除草剂
- 2000/60/EC, Alpha sort, Alphabetic, Amines, Analytical Standards,
- {SNA} 2000/60/EC, Additional Standards, Amines, Analytical Standards, Aromatics, Chemical Class, D, European Community: ISO, DIN and DL 152, Method and Regulation Specific, 农残和代谢标准品, 分析/色谱, 按照字母排序
- {SNA} Amines, Building Blocks, C6, Chemical Synthesis, Nitrogen Compounds, Organic Building Blocks
- {SNA} 2000/60/EC, Alphabetical Index of Analytical Standards, Amines, Analytical Standards,
产品应用
- 可作农药和染料的中间体。用于合成敌稗、利谷隆、敌草隆、灭草灵等除草剂及偶氮染料。也用作生物活性组分中间体。
相关文献及参考
- Merck: 14,3054
- Merck: 14,3054 Beilstein:12,626
- Short: III/31a
- Short: III/20b
安全信息
GHS Symbol
- H302 Harmful if swallowed 吞食有害
- H331 Toxic if inhaled 吸入中毒
- H311 Toxic in contact with skin 皮肤接触中毒
- H301 Toxic if swallowed 吞食有毒
- H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
- H318 Causes serious eye damage 严重伤害眼睛
- H317 May cause an allergic skin reaction 可能导致皮肤过敏
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- P332+P313
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- P301+P312+P330
- P302+P350
- P403+P233
- P305+P351+P338+P310
- P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P284 Wear respiratory protection.? 佩戴呼吸保护装置。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
- P304+P340+P311
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P285 In case of inadequate ventilation wear respiratory protection. 在通风不足的情况下,戴呼吸防护。
- P273 Avoid release to the environment. 避免释放到环境中。
- P308+P311
- P301+P310
- P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
- P302+P352+P312+P361+P364
- P405 Store locked up. 上锁保管。
- P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
- R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
- R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
- R50/53
- R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - wild bird species DOSE/DURATION : 237 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 675 mg/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 700 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 280 mg/kg TOXIC EFFECTS : Behavioral - excitement Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes REFERENCE : LPPTA
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Mold - Aspergillus nidulans DOSE/DURATION : 200 mg/L REFERENCE : CJMIAZ Canadian Journal of Microbiology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.1- 1954- Volume(issue)/page/year: 16,369,1970
TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 125 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 226,197,1989
其他信息
- TCI Shanghai:3,4-二氯苯胺 3,4-Dichloroaniline,>;98.0%(GC)(95-76-1)
- 用途一:用作医药、农药、染料的中间体
- 毒性分级:中毒
- 刺激数据:皮肤-兔子2 毫克/24小时 重度; 眼睛-兔子 0.25 毫克/24小时 重度
- 急性毒性:口服-大鼠 LD50: 545 毫克/公斤 ;口服-小鼠 LD50: 740 毫克/公斤
- Sigma Aldrich:95-76-1(sigmaaldrich)
- 储运特性:库房通风低温干燥; 与氧化剂、食品添加剂、酸类分开存放
- 可燃性危险特性:明火可燃燃烧释放有毒氯化物, 氮氧化物烟雾
- 类别:有毒物品
- 防护措施:有毒。能引起呼吸系统、神经系统及造血系统的病变。小鼠灌胃LD50为1000mg/kg,大鼠灌胃LD50为700mg/kg。大鼠的嗅觉阈0.047mg/m3;眼睛光感最低0.025mg/kg。设备应密闭,防止跑、冒、滴、漏。操作时应穿戴防护用具,避免与人体直接接触。操作场所空气中最高容许浓度0.05mg/m3。
- 图谱信息:3,4-二氯苯胺(95-76-1)核磁图( 1 HNMR) 3,4-二氯苯胺(95-76-1)核磁图( 13 CNMR) 3,4-二氯苯胺(95-76-1)红外图谱(IR2) 3,4-二氯苯胺(95-76-1)红外图谱(IR1) 3
- 用途三:可作农药和染料的中间体。用于合成敌稗、利谷隆、敌草隆、灭草灵等除草剂及偶氮染料。也用
- MSDS 信息:3,4-二氯苯胺(95-76-1).msds
- 防护措施:有毒。能引起呼吸系统、神经系统及造血系统的病变。小鼠灌胃LD50为1000mg/kg,大鼠灌胃LD50为700mg/kg。大鼠的嗅觉阈0.047mg/m3;眼睛光
- 用途二:3,4-二氯苯胺是除草剂敌稗、敌草隆、利谷隆、草不隆等的中间体。
- 上游原料:氯 --> 氢 --> 三氯化铁 --> 邻二氯苯 --> 4-硝基氯苯 --> 工业乙醇 --> 3,4-二氯硝基苯
- Alfa Aesar:3,4-二氯苯胺,98% 3,4-Dichl
- 下游产品:3,4-二氯-N-甲基苯胺 --> 敌稗 --> 敌草隆 --> 1-(3,4-二氯苯基)哌嗪 --> 3,4-二氯苯异氰酸酯 --> 2-氨基-5,6-二氯苯甲酸 --> 灭草灵 --> 5-[(3,4-二氯苯)偶氮基]-1,2-二氢-6-羟基-1,4-二甲基-2-氧代-3
- 存储注意事项:光敏感
- 外观性质:褐色针状结晶。
- 海关编码:29214210
- Acros Organics:3,4-二氯苯胺 3,4-Dichloroaniline, 98%(95-76-1)
- 方法一:其制备方法是在反应釜中加入对氯硝基苯、无水三氯化铁催化剂,于100~110℃通入氯气,当测定氯化反应物凝固点到30~31℃时即为反应终点。将此物移至还原釜,再加入硫代硫酸钠(以消除反应物中剩余氯的影响)、甲酸,加热到100℃(回流状态)慢慢加入铁粉(约4~5h加完),而后继续保持回流反应,当观察不到硝基苯存在时即为反应终点。加入3,4-二氯苯胺产量5~6倍的氯苯,搅拌0.5~1.0 h,经冷却、过滤并以少量氯苯洗涤滤渣,所得滤液为3,4-二氯苯胺的氯苯溶液,加热脱氯苯得3,4-二氯苯胺。 也可以用3,4-二氯硝基苯催化加氢而制得。在高压釜中加入3,4-二氯硝基苯,并加入兰尼镍催化剂,工业乙醇为溶剂,用氮气赶高压系统3次,氢气赶3次,然后充氢气达压力为4 MPa,同时升温至60~70℃进行反应,直到不吸收氢气为止,然后冷却经后处理可得成品。 此外,也可用邻二氯苯为原料,经硝化得3,4-二氯硝基苯,再进一步还原得成品。国外大部分企业用此法生产3,4-二氯苯胺。
- MOL 文件:95-76-1.mol
- 常规方法:用铁桶包装,一般自用。以铁罐贮存,泵输送。