4-Aminosalicylic Acid 对氨基水杨酸
CAS 65-49-6 MFCD00007789
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分类
- {SNA} Aromatic Amino Acids, Chemical Biology, Chemical Synthesis, Peptide Chemistry, Unnatural Amino Acid Derivatives
- {SNA} A-AM, Aromatic Amino Acids, Bioactive Small Molecules, Cell Biology, Chemical Biology, Chemical Synthesis, Peptide Chemistry, Unnatural Amino Acid Derivatives
- {SNA} A-AM, Aromatic Amino Acids, Bioactive Small Molecules, Chemical Biology, Chemical Synthesis, Peptide Chemistry, Unnatural Amino Acid Derivatives, 细胞生物学
- {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; carboxylic acid; alcohol; 1fragment
- Pharmaceuticals
- {SNA} Aromatic Amino Acids, Chemical Biology, Chemical Synthesis, Peptide Chemistry,
产品应用
- A antibacterial capable of inhibiting the growth of Mycobacterium tuberculosis
相关文献及参考
- Fourches, D., et al.: Chem. Res. Toxicol., 23, 171 (2010),
- Horita, Y., et al.: Bioorg. Med. Chem. Lett., 19, 6313 (2009),
- Short: II/27C
- Merck: 14,477
- Merck: 14,477 Beilstein:14(3)1436
- Short: II/27B
- Martins, M., et al.: J. Biol. Chem., 284, 18726 (2009),
安全信息
GHS Symbol
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- R22 Harmful if swallowed 吞咽有害
- R36 Irritating to eyes 刺激眼睛
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R45 May cause cancer 可能致癌
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P302+P350
- P302+P352+P332+P313+P362+P364
- P305+P351+P338
- P305+P351+P338+P337+P313
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
- P332+P313
- P337+P313
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
- H319 Causes serious eye irritation 严重刺激眼睛
- H303 May be harmfully swallowed 吞食可能有害
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 2,764,1950
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : R
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 2,764,1950
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3898 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 18,249,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 3650 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 10,289,1951
TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Rodent - mouse Mammary gland DOSE/DURATION : 2 mmol/L/24H (Continuous) REFERENCE : JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 5,141,1980
TYPE OF TEST : Cytogenetic analysis ROUTE OF EXPOSURE : Oral TEST SYSTEM : Rodent - mouse DOSE/DURATION : 50 mg/kg REFERENCE : NULSAK Nucleus (Calcutta). (Dr. A.K. Sharma, Centre of Advanced Studies in Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd., Calcutta 700 019, India) V.1- 1958- Volume(issue)/page/year: 22,96,1979
其他信息
- 用途一:作为镀锌光亮剂,整平剂和匀镀剂,用于碱性镀锌
- 4-Aminosalicylic acid is an inhibitor of NF κ B.
- TCI Shanghai:4-氨基水杨酸 4-Aminosalicylic Acid,>;97.0%(T)(65-49-6)
- 毒性分级:中毒
- Sigma Aldrich:65-49-6(sigmaaldrich)
- 用途四:有机合成。医药。医药中间体,用于合成抗结核病药对氨柳酸钠。也用于分析出试剂酸碱荧光指示剂。
- 刺激数据:眼睛-兔子 100 毫克/24小时 中度
- {Chemicalbook
- 可燃性危险特性:可燃;燃烧产生有毒氮氧化物烟雾
- 类别:有毒物品
- MOL 文件:65-49-6.mol
- 急性毒性:腹腔-小鼠LD50: 4250 毫克/公斤;口服-小鼠LD50: 4000 毫克/公斤
- 下游产品:双烯大分子单体共聚物光学塑料 --> 4-乙酰氨基-2-甲氧基苯甲酸甲酯 --> 对乙酰氨基-邻甲氧基苯甲酸甲酯 --> 4-氯水杨酸
- 可燃性危险特性:可燃;燃烧产生有毒氮氧化物
- {
- 用途二:医药中间体,用于合成抗结核药对氨基水杨酸钠
- 图谱信息:4-氨基水杨酸(65-49-6)红外图谱(IR1) 4-氨基水杨酸(65-49-6)质谱(MS) 4-氨基水杨酸(65-49-6)红外图谱(IR2)
- 储运特性:库房通风低温干燥
- 对光敏感。露于空气中易变棕色。溶解度: 2 g/L水 (20°C)、1g/21ml乙醇,溶于稀硝酸、稀氢氧化钠溶液,微溶于乙醚,几乎不溶于苯。
- 上游原料:硝酸 --> 甲醇钠 --> 二氧化碳 --> 亚硫酸钠 --> 硫化钠 --> 氢氧化钾溶液 --> 苯乙酸 --> 3-氨基苯酚 --> 酯化物 --> 邻羟基苯甲腈 --> 亚硝酸丁酯 --> 2,4-二硝基苯乙酸甲酯 --> 2,4-二硝基苯乙酸 --> 4-硝基水杨酸
- 用途三:医药中间体,用于合成抗结核病药对氨柳酸钠。也用于分析出试剂酸碱荧光指示剂。
- Acros Organics:4-氨基水杨酸 4-Aminosalicylic acid, 99%(65-49-6)
- 4-氨基水杨酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 L0983201 4-氨基水杨酸98% 100g 1
- 方法一:由间氨基酚经羟化而得。将水、间氨基酚和碳酸氢钠依次投入反应罐内,通入二氧化碳置换空气后,密闭升温至110±1℃,罐内压力保持0.6-0.8MPa反应6h,冷却至-5℃,加亚硫酸钠,过滤,水洗,合并洗滤液供酸化用。滤饼为间氨基酚回收物,套用。将上述洗滤液升温至10-15℃,用30-40%硫酸中和至pH为6.4-7.0,加入适量的亚硫酸钠与硫化钠溶液,经树脂脱色后,于30℃用30-40%硫酸调节至pH为3- 3.5,放置,甩滤,水洗至硫酸根合格,甩干得对氨基水杨酸。从苯乙酸出发也可以合成得到对氨基水杨酸。先使苯乙酸在浓硫酸和浓硝酸中在60℃下硝化,然后倾入冰水中,过滤析出2,4-二硝基苯乙酸[643-43-6]。硝化产率95%。将得到的产物加入10倍甲醇中,均匀混合后,通入干燥的氯化氢,加热至沸,冷却后析出2,4-二硝基苯乙酸甲酯晶体[58605-12-2]。酯化产率为80%。将酯化物溶解于热甲醇中,加入亚硝酸丁酯,再加入甲醇钠,静置数小时直至完全析出深红色沉淀物,分离沉淀物得中间产物。将其溶于稀氢氧化钾溶液中,加入盐酸酸化,使呈酸性。逸出二氧化碳气体,析出4-硝基-2-羟基苯腈。产率为80%,将此腈化物与水、浓硫酸、冰醋酸混合加热至沸,即可析出4-硝基水杨酸[619-19-2]。将4-硝基水杨酸溶解于25%碳酸钠溶液中,加入硫酸亚铁水溶液,再加适量的碳酸钠溶液,加热至沸,分离析出铁盐。过滤,滤液用乙酸调至pH=3,4-氨基水杨酸则析出。再过滤干燥,即得产品。工业品对氨基水杨酸含量大于70%,氯化物小于50ppm,硫酸根小于500ppm。