2-Methylbenzene-1-Sulfonamide 邻甲苯磺胺
CAS 88-19-7 MFCD00007934
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资金保障
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信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- Mutagenesis Research Chemicals
- {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; 1fragment
- Impurities
- Sulfur & Selenium Compounds
- {SNA} Building Blocks, Chemical Synthesis, Organic Building Blocks, Sulfonamides/Sulfinamides, Sulfur Compounds
- {SNA} Analytical Standards, Pharmacopeia & Metrological Institutes Standards, USP Standards, USP Standards S - T, 分析/色谱
- {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Standards, Pharmacopeia Standards, USP Standards, USP Standards S - T
- Aromatics
- {SNA} Analytical Standards, Chromatography, Pharmaceutical Standards, Pharmacopeia Standards, USP Standards, USP Standards S - T, 分析/色谱
产品应用
- o-Toluenesulfonamide is a methylated sulfonamide and a major impurity if Saccharin (S080800). Studies suggest that o-Toluenesulfonamide has potential mutagenic activity.
相关文献及参考
- Short: III/20a
- Short: EINECS
- Short: III/5a
- Beilstein:11(3)167
- Stavric, B. et al.: J. Assoc. Offic. Anal. Chem., 57, 678 (1974); Ashby, J. et al.: Food Cosm. Toxicol., 16, 95 (1978); Eckhardt, K. et al.: Toxicol. Lett., 7, 51 (1980);
安全信息
GHS Symbol

- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P405 Store locked up. 上锁保管。
- P305+P351+P338+P337+P313
- P308+P313
- P337+P313
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- H351 Suspected of causing cancer 怀疑致癌
- H319 Causes serious eye irritation 严重刺激眼睛
- H303 May be harmfully swallowed 吞食可能有害
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 13 gm/kg/96W-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - leukemia Kidney, Ureter, Bladder - Kidney tumors REFERENCE : ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. (Berlin, Fed. Rep. Ger.) V.76-92, 1971-78. For publisher information, see JCROD7. Volume(issue)/page/year: 91,19,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4870 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1073,1986
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 70 umol/plate REFERENCE : 45OHAA "Short-Term Test Systems for Detecting Carcinogens, Proceedings of the Symposium, 1978," Norpoth, K.H., and R.G. Garner, eds., Berlin, Springer-Verlag, 1980 Volume(issue)/page/year: -,170,1980
TYPE OF TEST : Sex chromosome loss and nondisjunction ROUTE OF EXPOSURE : Parenteral TEST SYSTEM : Insect - Drosophila melanogaster DOSE/DURATION : 5 mmol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 56,163,1977
TYPE OF TEST : Sex chromosome loss and nondisjunction ROUTE OF EXPOSURE : Oral TEST SYSTEM : Insect - Drosophila melanogaster DOSE/DURATION : 2500 umol/L REFERENCE : 45OHAA "Short-Term Test Systems for Detecting Carcinogens, Proceedings of the Symposium, 1978," Norpoth, K.H., and R.G. Garner, eds., Berlin, Springer-Verlag, 1980 Volume(issue)/page/year: -,170,1980
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 4300 mg/kg SEX/DURATION : female 1-22 day(s) after conception lactating female 21 day(s) post-birth TOXIC EFFECTS : Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 51,455,1979
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE : 1 gm/kg SEX/DURATION : female 10 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - other measures of fertility REFERENCE : PCBRD2 Progress in Clinical and Biological Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1975- Volume(issue)/page/year: 109,339,1982
其他信息
- 溶于乙醇和碱溶液,微溶于水和乙醚。