CAS N/A MFCD00008032-Acrylamide 丙烯酰胺 TAO{mole}

Acrylamide 丙烯酰胺

CAS N/A MFCD00008032

化学结构图

SMILES:

化学属性

Mol. Formula	C3H5NO
Mol. Weight	71.08
Boiling Point	125°C/25mmHg(lit.)
Melting Point	83.0 to 87.0 deg-C
Density	1.1
Flash Point	138°(280°F)
TSCA	Yes
Vapor Density	2.45 (vs air)
Vapor Pressure	0.03 mmHg ( 40 °C)
Solubility	可溶, 216 G/100 ML
Stability	对光敏感
Appearance	powder
Refractive index	1.460

别名和识别编码

Chemical Name	Acrylamide
CAS Number	79-06-1
Synonym	Acrylsäureamid 2-Propenamide Acrylamid D 丙烯酰胺水合液 acrylamide(solide) Ethylenecarboxamide 2-Propeneamide Ethylencarboxamid NSC 7785 2-丙烯酰胺丙烯酸酰胺 ACRYLAMIDE MONOMER 丙烯酰胺, 98+% 2-丙烯酰胺;丙烯酸酰胺 ETHYLENECARBOXAMIDE ACRYLAMIDE 2K Acryl amide 丙烯醯胺050-01[6] ACRYLIC ACID AMIDE ACRYLAMIDE HGX Acrylic Amide 丙烯酰胺丙烯酸酰胺 acrylamide,hydrate Amid kyseliny akrylove Vinyl amide Vinyl Amide Propenamide aam 2-丙烯酰胺 ACRYL-40(TM) Bio-Acrylamide 50 ACRYLAMIDE-HG Acrylamide 2-Propensäureamid RCRA waste number U007 PREMIX ACRYLAMIDE Propenoic acid amide Akrylamid acrylamide(non-specificname) Acrylic amide 丙烯酰胺, ELECTROPHORESIS GRADE, 99+%
PubChem Substance ID	87561828
EC Number	201-173-7
Beilstein Registry Number	2(4)1471
MDL Number	MFCD00008032
Reaxys-RN	605349
Merck Number	129
Chemical Name Translation	丙烯酰胺
Wiswesser Line Notation	ZV1U1
LabNetwork Molecule ID	LN00198833

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分类

{SA} Acrylamides, Core Bioreagents, Electrophoresis of Glycans, Glycan Labeling and Analysis, Glycobiology, Life Science Reagents for DNA/RNA Electrophoresis, Life Science Reagents for Western Blotting, Post-Translational Modification, Protein Electrophoresis, Proteomics, Research Essentials, SDS-PAGE
Protein Sequencing, Protein Structural Analysis, Proteomics, Reagents for Protein Sequencing
{SNA} Acrylamides, Core Bioreagents, Electrophoresis of Glycans, Glycan Labeling and Analysis, Glycobiology, Life Science Reagents for DNA/RNA Electrophoresis, Life Science Reagents for Western Blotting, Post-Translational Modif
{uni_hamburg} no charge; amide; 1fragment

产品应用

制备聚丙烯酰胺凝胶，供电泳测定蛋白质分子量等。絮凝剂, 土壤稳定剂，增强纸张强度，改进纤维质量，粘结剂。

安全信息

GHS Symbol

WGK Germany3

Hazard statements

H301+H311
H312+H332
H315 Causes skin irritation 会刺激皮肤
H317 May cause an allergic skin reaction 可能导致皮肤过敏
H301 Toxic if swallowed 吞食有毒
H350 May cause cancer 可能致癌
H340 May cause genetic defects 可能导致遗传性缺陷
H319 Causes serious eye irritation 严重刺激眼睛
H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
H372 Causes damage to organs through prolonged or repeated exposure 长期或频繁接触会损伤器官
H330 Fatal if inhaled 吸入致命
H302 Harmful if swallowed 吞食有害
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难

Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

Hazard Codes T

RTECSAS3325000

Precautionary statements

P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338
P308+P313
P501 Dispose of contents/container to..… 处理内容物/容器.....
P302+P350
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P201 Obtain special instructions before use. 使用前获取专门指示。
P284 Wear respiratory protection.? 佩戴呼吸保护装置。
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P301+P310
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P273 Avoid release to the environment. 避免释放到环境中。
P305+P351+P338+P337+P313
P308+P311
P301+P310+P330
P302+P352+P312+P361+P364
P405 Store locked up. 上锁保管。
P333+P313
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。

Signal word

Safety Statements

Risk Statements

R25 Toxic if swallowed 吞咽有毒
R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
R46 May cause inheritable genetic damage 可能引起遗传基因损害
R45 May cause cancer 可能致癌
R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
R48/23/24/25
R62 Possible risk of impaired fertility 有削弱生殖能力的危险
R20/21 Harmful by inhalation and in contact with skin 吸入及与皮肤接触有害
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R48/20/21/22
R22 Harmful if swallowed 吞咽有害

UN Number 2074

Storage condition 充氩保存。充氩保存密封阴凉避光保存。 Light Sensitive Air & Light Sensitive 2-8°C

Packing GroupIII

Hazard Class6.1

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 24 mg/kg/8W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   44,107,1984

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 72 mg/kg/8W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   44,107,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 300 mg/kg/2W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Skin and Appendages - tumors
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   24,209,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1456 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Reproductive - Tumorigenic effects - testicular tumors
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/y

TYPE OF TEST

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 107 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   47,179,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percen

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1680 uL/kg
TOXIC EFFECTS :
   Behavioral - hallucinations, distorted perceptions
REFERENCE :
   ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
   Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)  V.1-
   1990-  Volume(issue)/page/year: 1,115,1990

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 190 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences.
   (Paris, France)  V.1-261, 1835-1965.  For publisher information, see CRASEV.
    Volume(issue)/page/year: 153,895,1911

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 90 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et de
   Securite Sociale.  (SPPIF, B.P.22, F-41353 Vineuil, France)  V.7-    1946-
   Vo

TYPE OF TEST            : Specific locus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 226,157,1989

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 100 mg/kg
REFERENCE :
   MUREAV Mutation

TYPE OF TEST            : Sister chromatid exchange
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 600 mg/kg/10D (Continuous)
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 7(Suppl
   3),79,1985

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 300 mg/L
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-  Volume(issue)/page/year: 3,263,1988

TYPE OF TEST            : Dominant lethal test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 150 mg/kg/5D (Continuous)
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-  Volume(issue)/page/year: 2,215,1987

TYPE OF TEST            : Dominant lethal test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 125 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 173,35,1986

TYPE OF TEST

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 95 gm/kg
SEX/DURATION            : female 4 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Ber

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 250 mg/kg
SEX/DURATION            : male 5 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   CGANE7 Congenital Anomalies.  (Nippon Senten Ijo Gakkai, 377-2 Ono-higashi,
   Osakasayama, Osaka-Fu 589 Japan)  V.27-    1987-  Volume(issue)/page/year:
   34,35,1994

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 225 mg/kg
SEX/DURATION            : female 10-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 226,157,1989

Warnings 危险化学品

其他信息

上游原料:氨 --> 丙烯腈 --> 丙烯酸 --> 卡波姆树脂 --> 催化剂 --> 吩噻嗪 --> 丙烯酰胺水溶液 --> 抑制剂
用途六:制备聚丙烯酰胺凝胶，供电泳测定蛋白质分子量等。絮凝剂, 土壤稳定剂，增强纸张强度，改进纤维质量，粘结剂。
食品中形成:丙烯酰胺主要在高碳水化合物、低蛋白质的植物性食物加热(120°C 以上)烹调过程中形成。140-180℃为生成的最佳温度，而在食品加工前检测不到；在加工温度较低，如用水煮时，丙烯酰胺的水平相当低。水含量也是影响其形成的重要因素，特别是烘烤、油炸食品最后阶段水分减少、表面温度升高后，其形成量更高；但咖啡除外，在焙烤后期反而下降。丙烯酰胺的主要前体物为游离天门冬氨酸（土豆和谷类中的代表性氨基酸）与还原糖，二者发生Maillard反应（一种发生在氨基酸和还原糖之间的非酶褐变反应）生成。食品中形成的丙烯酰胺比较稳定；但咖啡除外，随着储存时间延长，含量反而会降低。
控制与预防:1，职业性接触者要通过改革工艺、采取工程技术措施等手段，降低工作场所空气中丙烯酰胺的浓度；同时通过加强个人防护，如戴口罩、手套，穿防护服和鞋等，以防止或减少其进入体内。 2，日常生活中尽量避免过度烹饪食品，如温度过高或加热时间太长。提倡平衡膳食，减少油炸和高脂肪食品的摄入，多吃水果和蔬菜，不要吸烟。 3，由于煎炸食品是我国居民常吃的食物，国家应加强膳食中丙烯酰胺的监测与控制，开展我国人群丙烯酰胺的暴露评估，并研究探索降低加工食品中含量的方法。
用途四:聚
合成:19世纪末，人类首次从丙烯酰氯与氨合成了丙烯酰胺。 1954年，美国氰氨公司采用丙烯腈硫酸水解工艺进行工业生产。 1972年，日本三井东压化学公司首先建立了骨架铜（见金属催化剂）催化丙烯腈水合制丙烯酰胺的工业装置，此后各国相继开发了不同类型的催化剂，采用此项工艺进行工业生产。 80年代，日本日东化学工业公司实现了用生物催化剂由丙烯腈制丙烯酰胺的工业生产。硫酸水合法丙烯腈和水在硫酸存在下水解成丙烯酰胺的硫酸盐，然后用液氨中和生成丙烯酰胺和硫酸铵： CH2＝CHCN+H2O+H2SO4 ─→CH2＝CHCONH2·H2SO4 CH2＝CHCONH2·H2SO4+2NH3─→CH2＝CHCONH2+(NH4)2SO4 此法的缺点是副产大量价值低廉、肥效不高的硫酸铵，又存在严重的硫酸腐蚀和污染等问题。催化水合法丙烯腈与水在铜系催化剂的作用下，于70～120℃、0.4MPa压力下进行液相水合反应。 CH2＝CH-CN+H2O─→CH2＝CHCONH2反应后滤去催化剂，回收未反应的丙烯腈，丙烯酰胺水溶液经浓缩、冷却得结晶。该法工艺流程简单，收率可达98％以上。
用途五:丙烯酰胺是丙烯酰胺系和甲基丙烯酰胺系产品中最重要的产品。自1954年用于工业后，需要逐步增长。主要用来制取能溶于水的聚合物，而这种聚丙烯酰胺可作为添加剂用以提高石油的回收率；用作絮凝剂、增厚剂和造纸助剂。少量丙烯酰胺被用来将亲水中心引入亲油的聚合物中以改善粘度，提高软化点和提高树脂的抗溶剂性，并且可以为染料的受色性引入一个中心。丙烯酰胺还常常被用作感光聚合物的一个组分。在乙烯基聚合物中，在交联反应中可以使用这种酰胺基的反应活性。丙烯酰胺可以与某些单体，如乙酸乙烯、苯乙烯、氯乙烯、乙烯叉二氯、丙烯腈等共聚获得具有多种用途的聚合物。主要应用领域：(1)油田用该品用于油田注水井调整吸水剖面。将本品与引发剂、除氧剂等混合，注入注水井高渗透层带。在地层下聚合成高粘度的聚合物。封堵大孔道，增加扫油体积，提高采油率。此外，本品的聚合物或共聚物，可用于三次采油、压裂、堵水、钻井混浆处理以及化学灌浆等。(2)作絮凝剂该品的部分水解物或与甲基纤维素的接枝共聚物，用于工厂废水处理及下水处理。(3)土壤改良剂利用该品水解物作土壤改良剂，可使土壤团粒化，改善空气流通性、水渗透性和保水性。(4)纤维改性与树脂加工将丙烯酰胺进行氨基甲酰化或接枝聚合。可用于改善含合成纤维的各种纤维的树脂整理，经纱以及作印染浆料使用，以改善纤维织物的基础物性，防皱、防缩和手感好。(5)纸力增强剂丙烯酰胺与丙烯酸的共聚物或聚丙烯酰胺的部分水解物，可用作纸力培强剂，代替已经使用的淀粉、水溶性氨基树脂或者共用。(6)胶粘剂有聚丙烯酰胺与酚醛树脂溶液并用的玻璃纤维胶粘剂，以及与合成橡胶并用的压敏胶。
Sigma Ald