(1R,2S)-(-)-Norephedrine

CAS 492-41-1 MFCD00008079

化学结构图

492-41-1
SMILES:

化学属性

Mol. FormulaC6H5CH(OH)CH(CH3)NH2
Mol. Weight151.21
Melting Point51-53 °C(lit.)

别名和识别编码

Chemical NameNorephedrine, (-)-
Synonym (1R,2S)-(-)-去甲麻黄素 USAF CS-6
PubChem Substance ID24857054
EC Number207-755-7
Beilstein Registry Number2207678
MDL NumberMFCD00008079
Wiswesser Line NotationZY1&YQR -L
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分类

  • {SNA} Alkaloid, Asymmetric Synthesis, Bioactive Small Molecules, Cell Biology, Chemical Synthesis, Chiral Auxiliaries, Ephedra sinica, Ephedrine Derivatives, N, Nutrition Research, Phytochemicals by Chemical Classification, Phytochemicals by Plant (Food/Spice/Herb)

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H302 Harmful if swallowed 吞食有害
  • H319 Causes serious eye irritation 严重刺激眼睛
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
RTECSRC2275000
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Signal word Warning
Hazard Codes Xn
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
Restrict 易制毒化学品
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 45 mg/kg/30D-I
TOXIC EFFECTS :
   Cardiac - cardiomyopathy including infarction
   Cardiac - EKG changes not diagnostic of specified effects
   Vascular - BP elevation not characterized in autonomic section
REFERENCE :
   AEMED3 Annals of Emergency Medicine.  (American College of Emergency
   Physicians, 1125 Executive Circle, Irving, TX 75038)
   Volume(issue)/page/year: 28,359,1996

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 2500 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - headache
REFERENCE :
   AJDCAI American Journal of Diseases of Children.  (AMA, 535 N. Dearborn St.,
   Chicago, IL 60610) V.1-80(3), 1911-50; V.100-    1960-
   Volume(issue)/page/year: 138,683,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 1071 ug/kg/1D-I
TOXIC EFFECTS :
   Behavioral - wakefulness
   Behavioral - euphoria
   Behavioral - toxic psychosis
REFERENCE :
   HETOEA Human & Experimental Toxicology.  (Macmillan Press Ltd., Brunel Road,
   Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
   Volume(issue)/page/year: 11,295,1992

系列性分类


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