1,4-Diaminobutane 1,4-二氨基丁烷
CAS 110-60-1 MFCD00008235
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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分类
- {SNA} All Alphabetically Sorted, Alphabetical Index of Analytical Standards, Amino Acids, Peptides & Proteins, Analytical Standards, Analytical/Chromatography, Biogenic Amines, Chromatography, Flavors and Fragrances, Food & Beverage Standards, Life Sciences Standards, M-R, P, PU - PZ, Polyamine, Substance Classification, other
- {SNA} Bioactive Small Molecules, Building Blocks, Chemical Synthesis, D-DIF, Hordeum vulgare (Barley), Nitrogen Compounds, Nutrition Research, Organic Building Blocks, Phytochemicals by Plant (Food/Spice/Herb),
- {SNA
产品应用
- A GABA precursor in many biological systems.
相关文献及参考
- [2]. Sequerra EB, et al. Putrescine as an important source of GABA in the postnatal rat subventricular zone. Neuroscience. 2007 May 11;146(2):489-93.
- 2. J. Chem. Soc. Perkin Trans. I , 3179, (1992)
- Merck:14,7947
- Merck:14,7947 Beilstein:4,264
- Short: EINECS
- Short: III/31a
- [1]. Hauschild MZ. Putrescine (1,4-diaminobutane) as an indicator of pollution-induced stress in higher plants: barley and rape stressed with Cr(III) or Cr(VI). Ecotoxicol Environ Saf. 1993 Oct;26(2):228-47.
- [1]. Hauschild MZ. Putrescine (1,4-diaminobutane) as an indicator of pollution-induced stress in higher plants: barley and rape stressed with Cr(III) or Cr(VI). Ecotoxicol Environ Saf. 1993 Oct;26(2):228-47.
- [2]. Sequerra EB, et al. Putrescine as an important source of GABA in the postnatal rat subventricular zone. Neuroscience. 2007 May 11;146(2):489-93.
安全信息
GHS Symbol
- H228 Flammable solid 易燃固体
- H226 Flammable liquid and vapour 易燃液体和蒸气
- H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
- H302+H312
- H331 Toxic if inhaled 吸入中毒
- H330 Fatal if inhaled 吸入致命
- H302 Harmful if swallowed 吞食有害
- H311 Toxic in contact with skin 皮肤接触中毒
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- P303+P361+P353
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
- P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
- P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
- P403+P233
- P305+P351+P338+P310
- R11 Highly flammable 非常易燃
- R34 Causes burns 会导致灼伤
- R21/22 Harmful in contact with skin and if swallowed 皮肤接触和不慎吞咽有害
- R23 Toxic by inhalation 吸入有毒
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
- S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 463 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Sense Organs and Special Senses (Eye) - ptosis Kidney, Ureter, Bladder - other changes in urine composition REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0538638
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1750 mg/kg TOXIC EFFECTS : Behavioral - muscle contraction or spasticity Vascular - BP lowering not characterized in autonomic section REFERENCE : FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 18(6),9,1955
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 1576 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Kidney, Ureter, Bladder - other changes in urine composition Skin and Appendages - dermatitis, othe
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Rectal SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849- Volume(issue)/page/year: 83,481,192
TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - mouse Liver DOSE/DURATION : 20 mmol/L REFERENCE : AMOKAG Acta Medicia Okayama. (Okayama Univ. Medical School, Okayama, Japan) V.27 1973- Volume(issue)/page/year: 33,149,1979
TYPE OF TEST : Unscheduled DNA synthesis TEST SYSTEM : Rodent - mouse Liver DOSE/DURATION : 2 mmol/L REFERENCE : AMOKAG Acta Medicia Okayama. (Okayama Univ. Medical School, Okayama, Japan) V.27 1973- Volume(issue)/page/year: 33,149,1979
TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - mouse Ascites tumor DOSE/DURATION : 10 mmol/L REFERENCE : AMOKAG Acta Medicia Okayama. (Okayama Univ. Medical School, Okayama, Japan) V.27 1973- Volume(issue)/page/year: 33,149,1979
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE : 314 mg/kg SEX/DURATION : female 12 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - other effects to embryo Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 28,237,1983
其他信息
- Alfa Aesar:1,4-二氨基丁烷,98+% 1,4-Diaminobutane, 98+%(110-60-1)
- 外观性质:无色结晶,有六氢吡啶的气味。
- 毒性分级:中毒
- Acros
- 急性毒性:口服-小鼠 LDL0: 1600 毫克/公斤
- 存储注意事项:氮气保护;空气敏感
- 检测方法:GC,NMR
- 类别:有毒物品
- MSDS 信息:1,4-丁二胺(110-60-1).msds
- 储运特性:库房通风低温干燥; 与氧化剂、酸类、食品化工添加剂分开存放
- 下游产品:2,3,5,6-四甲基吡嗪 --> N-叔丁氧羰基-1,4-丁二胺 --> 亚精胺 --> 菌核净
- 灭火剂:干粉、泡沫、二氧化碳、砂土
- 图谱信息:四亚甲基二胺 (110-60-1)质谱(MS) 四亚甲基二胺 (110-60-1)红外图谱(IR2) 四亚甲基二胺 (110-60-1)红外图谱(IR3) 四亚甲基二胺 (110-60-1)红外图谱(IR1)
- F:3-10-23-34
- Sigma Aldrich:110-60-1(sigmaaldrich)
- TCI Shanghai:1,4-丁二胺 1,4-Diaminobutane,>;98.0%(GC)(110-60-1)
- 1,4-Diaminobutane is a GABA precursor in many biological systems and synthon for amido-ureas.
- 用途一:有机合成中间体,用于制药和生化研究。
- 方法一:由吡咯与盐酸羟胺反应得丁二肟,再经还原而得丁二胺。
- 易溶于水,能吸收二氧化碳。有强烈氨臭。其盐酸盐[333-93-7]为白色结晶,熔点290℃,能溶于水,不溶于甲醇。
- 上游原料:氢氧化钠 --> 盐酸 --> N,N-二甲基甲酰胺 --> 碳酸钠 --> 氧化钙 --> 邻苯二甲酰亚胺 --> 二甲基乙二醛肟 --> 1,4-二氯丁烷
- MOL 文件:110-60-1.mol
- 可燃性危险特性:明火可燃;高热分解有毒氮氧化物烟雾
- 敏感性:Air Sensitive & Hygroscopic