Dimethyl Acetylenedicarboxylate(DMAD) 丁炔二酸二甲酯
CAS 762-42-5 MFCD00008456
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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分类
- {SNA} Building Blocks, C6 to C7, Carbonyl Compounds, Chemical Synthesis, Esters, Organic Building Blocks
- Building Blocks, C6 to C7, Carbonyl Compounds, Chemical Synthesis, Esters, Organic Building Blocks
产品应用
- 用于有机合成。
相关文献及参考
- Reacts with activated carbonyl compounds, such as ɑ-keto esters or ɑ-keto nitriles, in the presence of triphenylphosphine, to give highly functionalized -butyrolactones: J. Org. Chem., 61, 4516 (1996). For a further example with reaction scheme, see 2,2,2-Trifluoroacetophenone,
- Stabilized anions derived from cyclic ß-keto phosphonates undergo ring expansion, via a tandem Michael-Aldol-fragmentation mechanism, to give phosphonates with an additional two carbons in the ring, thus providing a route to highly functionalized medium ring compounds: J. Org. Chem., 60, 3084 (1995):
- Beilstein:2,803
- Reacts with activated carbonyl compounds, such as ɑ-keto esters or ɑ-keto nitriles, in the presence of triphenylphosphine, to give highly functionalized -butyrolactones: J. Org. Chem., 61, 4516 (1996). For a further example with reaction scheme, see 2,2,2-Trifluoroacetophenone, A11403.
- For use in the masking of double bonds for subsequent release by cycloreversion, see: J. Org. Chem., 44, 962 (1979). Review of cycloreversion reactions in organic synthesis: Synthesis, 121 (1985).
- Dienophile in Diels-Alder and related reactions. For addition to a bis-allene, followed by dimerization to a paracyclophane, see: Org. Synth. Coll., 7, 485 (1990).
- Used in synthesis of a wide variety of heterocyclic systems including benzo[b]thiophenes from thiophenols: Acta Chem. Scand., 27, 595 (1973), and chromones from phenols: Austral. J. Chem., 48, 677 (1995):
安全信息
GHS Symbol
- H227 Combustible liquid 可燃液体
- H302 Harmful if swallowed 吞食有害
- H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
- P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P330+P331+P310
- P303+P361+P353
- P303+P361+P353+P310+P363
- P304+P340+P310
- P305+P351+P338
- P305+P351+P338+P310
- P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
- P403+P235
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- R34 Causes burns 会导致灼伤
- S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S27 Take off immediately all contaminated clothing 立即脱掉全部污染的衣服;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,13,1953
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 550 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - ataxia Behavioral - coma REFERENCE : GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 28(6),55,1984
其他信息
- Sigma Aldrich:762-42-5(sigmaaldrich)
- 用途一:用于有机合成。
- Acros Organics:丁炔二酸二甲酯 Dimethyl acetylenedicarboxylate, 98%(762-42-5)
- F:8-19
- MOL 文件:762-42-5.mol
- 下游产品:尼多克罗 --> 2,3-喹啉二甲酸
- 上游原料:酞酸二甲酯 --> 二甲酸钾
- MSDS 信息:Acetylenedicarboxylic acid dimethyl ester(762-42-5).msds
- 丁炔二酸二甲酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 A0090 乙炔二羧酸二甲酯 Dimethyl Acetylenedicarboxylate 25ML 462元 2014/06/02 A0090 乙炔二羧酸二甲酯 Dimethyl Acetylenedicarboxylate 500ML 4600元 2010/06/21 115710250 丁炔二酸二甲酯 Dimethyl acetylenedicarboxylate 98% 25 GR 777元
- Alfa Aesar:丁炔二羧酸二甲酯,98% Dimethyl acetylenedicarboxylate, 98%(762-42-5)
- 丁炔二酸二甲酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 A0090 乙炔二羧酸二甲酯 Dimethyl Acetylenedicarboxylate 25ML 695元 2011/04/16 A0090 乙炔二羧酸二甲酯 Dimethyl Acetylenedicarboxylate 500ML 7130元 2010/06/21 115710250 丁炔二酸二甲酯 Dimethyl acetylenedicarboxylate 98% 25 GR 777元
- 海关编码:29171990
- 检测方法:GC,NMR
- TCI Shanghai:丁炔二酸二甲酯 Dimethyl Acetylenedicarboxylate,>;96.0%(GC)(762-42-5)
- 方法一:丁炔二甲酸钾与甲醇在浓硫酸存在下室温反应4d,以72-88%的收率生成丁炔二酸二甲酯。
- 敏感性:Light Sensitive