CAS 103-84-4 MFCD00008674-Acetanilide 乙酰苯胺 TAO{mole}

Acetanilide 乙酰苯胺

CAS 103-84-4 MFCD00008674

化学结构图

SMILES: CC(=O)Nc1ccccc1

化学属性

Mol. Formula	C8H9NO
Mol. Weight	135.16
Boiling Point	254.9±23.0 °C at 760 mmHg
Melting Point	113-115 °C
Density	1.22
Flash Point	145.6±11.9 °C
TSCA	Yes
Autoignition Point	1004 °F
Vapor Density	4.65 (vs air)
Vapor Pressure	1 mmHg ( 114 °C)
Solubility	溶于热水，易溶于乙醇、乙醚等。
Stability	对光敏感

别名和识别编码

Chemical Name	Acetanilide
CAS Number	103-84-4
Synonym	Acetanilide {LY} Acetanilide Acetoanilide Acetylaminobenzene Acetylanilide Acetylaniline Aceylaminobenzene Antifebrin Benzenamine, N-acetyl- Essigsäureanilid N-AcetylanilineN-Phenylacetamide N-phenylacetamide N-phenylethanamide N-乙醯苯胺 N-苯乙酰胺 N-苯乙醯胺 N-苯基乙酰胺 N-苯基乙酸胺,乙酰氨基苯,N-乙酰苯胺 NSC 203231 NSC 7636 Phenalgene Usaf ek-3 acetanilide acetonide acety {} {LY} Acetanilide {} {} {LY} Acetanilide {} {} {} {LY} Acetanilide {} {} {} {} {LY} Acetanilide {} {} {} {} {} {} {} {} {} {} {LY} Acetanilide {} {} {} {} {} {} {LY} Acetanilide {} {} {} {} {} {} {} {LY} Acetanilide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Acetanilide {} {} {} {} {} {} {} {} {} {LY} Acetanilide {} {} {} {} {} {} {} {
EC Number	203-150-7
Beilstein Registry Number	606468
MDL Number	MFCD00008674
PubChem Substance ID	904
Merck Number	14,50
Chemical Name Translation	乙酰苯胺
Wiswesser Line Notation	1VMR
LabNetwork Molecule ID	LN00199671
InChI	InChI=1S/C8H9NO/c1-7(10)9-8-5-3-2-4-6-8/h2-6H,1H3,(H,9,10)
Canonical SMILES	O=C(C)NC1=CC=CC=C1

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

检验铈、铬、铁、亚铁氰化物、铅、锰、氯化剂、硝酸盐。过氧化氢溶液的稳定剂，有机微量分析，测定氮的标准。乙酰苯胺也是磺胺类药物的原料。

安全信息

GHS Symbol

WGK Germany1

Hazard statements

H302 Harmful if swallowed 吞食有害
H315 Causes skin irritation 会刺激皮肤
H335 May cause respiratory irritation 可能导致呼吸道刺激
H319 Causes serious eye irritation 严重刺激眼睛

RTECSAD7350000

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338
P301+P312+P330

Signal word Warning

Hazard Codes Xn

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Safety Statements

S22 Do not breathe dust 不要吸入粉尘；
S36 Wear suitable protective clothing 穿戴适当的防护服；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R22 Harmful if swallowed 吞咽有害

Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

Warnings 危化品目录(2015)

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 56 mg/kg/H-I
TOXIC EFFECTS :
   Behavioral - hallucinations, distorted perceptions
   Gastrointestinal - decreased motility or constipation
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   AJMSA9 American Journal of the Medical Sciences.  (Slack Inc., 6900 Grove
   Rd., Thorofare, NJ 08086) New series: V.1-    1841- Volume(issue)/page/year:
   122,770,1901

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 14 mg/kg/D
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - cyanosis
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
   34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
   Academic Press, Inc., 1969  Volume(issue)/page/year: -,62,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 540 mg/kg
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 48,204,1959

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 59 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M.,
   Springfiel

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 80,761,1991

Restrict 危险品

其他信息

方法一:由苯胺经乙酸乙酰化而得。将苯胺和冰醋酸（过量100%）置于带夹套的搪玻璃反应器内，回流6-14h直至无游离苯胺为止。若用稀乙酸，则反应温度为150-
外观性质:无色有闪光的小叶状固体。
蒸气压:1 mm Hg ( 114 °C)
标准值不确定度单位
毒性分级:中毒
Sigma Aldrich:103-84-4(sigmaaldrich)
N-乙酰苯胺价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 81000217 乙酰苯胺;N-乙酰苯胺;退热冰 250g 32.9元 2011/08/23 81000380 乙酰苯胺;N-乙酰苯胺;退热冰 25g 21.4元 2011/08/23 81000227 乙酰苯胺;N-乙酰苯胺;退热冰 250g 31元
略有苯胺及乙酸气味。在水中再结晶析出呈正交晶片状。无气味，溶解度: 1g、185ml冷水，1G/20ML 沸水， 1G/3,4ML 乙醇 - 1G/4ML 丙酮 1G/3,7ML 氯仿 - 1G/5ML 甘油 1G/8ML 二噁烷 - 1G/18ML 醚 - 1G/47ML苯，微溶于石油醚。微溶于冷水，水合氯醛能增加其中在水中溶解度。碱性很弱。遇酸或碱性水溶液易分解成苯胺及乙酸。可燃，无臭。在空气中稳定，呈中性。约在95℃挥发。
常规方法:采用内层塑料袋、外层麻袋或帆布袋包装，每袋净重50kg。贮存在阴凉、干燥、通风处，防火、防潮。用汽车或火车运输均可。按有毒化学品规定贮运。
下游产品:磺胺 --> 4-氨基乙酰苯胺 --> 4-氨基苯乙酮 --> 磺胺喹恶啉 --> 磺草灵 --> 盐酸多西环素 --> 4-(4-氨基苯基)丁酸 --> 间氨基苯乙醚 --> 耐晒黄 G --> 柳氮磺吡啶 --> 2-[(4-氨基苯基)磺酰基]乙醇硫酸氢酯 --> 分散兰 301
上游原料:乙酸 --> 氨基苯 --> 2-苯甲酰乙酰苯胺 --> 蒸馏罐
图谱信息:N-乙酰苯胺(103-84-4)红外图谱(IR1) N-乙酰苯胺(103-84
急性毒性:口服- 大鼠 LD50: 800 毫克/ 公斤; 口服- 小鼠 LD50: 1210 毫克/ 公斤
方法一:由苯胺经乙酸乙酰化而得。将苯胺和冰醋酸（过量100%）置于带夹套的搪玻璃反应器内，回流6-14h直至无游离苯胺为止。若用稀乙酸，则反应温度为150-160℃，反应结束后趁热过滤，除去残渣，滤液冷却、结晶，离心过滤，水洗并干燥，即得产品。也可采用乙酐作酰化剂，反应在苯溶液中进行，乙酐过量150%。操作示例1将四只反应罐成梯形排列，最高一只反应罐装有分馏柱。苯胺从分馏柱顶部连续加入，回收乙酸与苯胺混合物从第二只反应罐连续加入，乙酸从第三只反应罐连续加入。控制不同的反应温度（第三只为160-170℃，第四只为200-210℃），使乙酸与苯胺进行气液相对流反应，反应生
MOL 文件:103-84-4.mol
类别:可燃物品
用途三:乙酰苯胺是磺胺类药物的原料，可用作止痛剂、退热剂和防腐剂。用来制造染料中间体对硝基乙酰苯胺、对硝基苯胺和对苯二胺。在第二次世界大战的时候大量用于制造对乙酰氨基苯磺酰氯（Acet
检测方法:HPLC、GC,NMR,Rotation
可燃性危
方法一:由苯胺经乙酸乙酰化而得。将苯胺和冰醋酸（过量100%）置于带夹套的搪玻璃反应器内，回流6-14h直至无游离苯胺为止。若
Alfa Aesar:乙酰苯胺,98% Acetanilide, 98%(103-84-4)