Diethyl pyrocarbonate 焦碳酸二乙酯
CAS 1609-47-8 MFCD00009106
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专业采购外包团队在线服务
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分类
- {SNA} Building Blocks, Carbonates, Carbonyl Compounds, Chemical Synthesis, Organic Building Blocks
- {SNA} Biochemicals,
- {SNA} Alternative Energy,
- {SNA} Alternative Energy, Building Blocks, Carbonates, Carbonyl Compounds, Chemical Synthesis,
- {SNA} Biochemicals, Biochemicals and Reagents, Carboxypeptidase P, Core Bioreagents, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates,
- {SNA
- {SNA} Alternative Energy, Building Blocks, Carbonates, Carbonyl Compounds, Chemical Synthesis, Electrolytes, Organic Building Blocks, Organic Solvents, 材料科学
- {SNA} Biochemicals,
产品应用
- 蛋白质组氨酸和酪氨酸的修饰试剂。也是RNA酶的化学修饰剂,它和RNA酶的活性基团组氨酸的咪唑环反应而抑制RNA酶活性。
相关文献及参考
- , Sambrook, J., et al. Molecular Cloning: A Laboratory Manual 2nd ed., Plainview, NY , (1989), 7.3-7.4
- In the presence of the hindered base lithium dicyclohexylamide (from Dicyclohexylamine, A15671), ɑ -ethoxycarbonylation of ketones occurs to give ß -keto esters: Synthesis, 1014 (1984).
- Merck:14,7998 Beilstein: 3,IV,18
- Merck:14,7998
安全信息
GHS Symbol
- H302 Harmful if swallowed 吞食有害
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H332 Harmful if inhaled 吸入有害
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P264+P265
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P312
- P301+P312+P330
- P301+P317
- P302+P352
- P304+P312
- P304+P340
- P305+P351+P338
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
- P319
- P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
- P330 Rinse mouth. 漱口
- P332+P313
- P332+P317
- P337+P313
- P337+P317
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
- P362+P364
- P403+P233
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- R22 Harmful if swallowed 吞咽有害
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S36 Wear suitable protective clothing 穿戴适当的防护服;
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1558 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 53A,52,1974
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 47 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 53A,52,1974
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 850 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 51A,67,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 53A,52,1974
TYPE OF TEST : LCLo - Lowest published lethal concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 10 ppm/1H TOXIC EFFECTS : Lungs, Thorax, or Respiration - dyspnea REFERENCE :
其他信息
- Diethyl Pyrocarbonate has been shown to inhibit ryanodine binding to ryanodine/Ca2+ receptor channels in skeletal muscle in a dose- and time-dependent manner and increases the Ca2+ permeability of SR vesicles. This compound could be useful for specific inactivation of nucleases during isolation of undegraded polynucleotides. Diethyl Pyrocarbonate also inhibits PAF Acetylhydrolase (platelet-activating factor acetyl hydrolase), and has been used as a probe for the topography of 5.8S rRNA in yeast ribosomes.
- 存储注意事项:氮气保护;湿度敏感
- 有轻微的似果酯香味。难溶于水,遇水分散成CO2及乙醇。与乙醇可混溶。溶于有机溶剂及油脂。
- Acros Organics:焦碳酸二乙酯 Diethyl pyrocarbonate, pure, 97%(1609-47-8)
- F:4.4-9-21
- MSDS 信息:Pyrocarbonic acid diethyl ester(1609-47-8).msds
- 焦碳酸二乙酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 L1152602 二碳酸二乙酯95% 25g 790元 2011/08/23 30061486 焦碳酸二乙酯(+4℃) 25ml 865元 2010/06/21 170255000 焦碳酸二乙酯 Diethyl pyrocarbonate 97%, pure 500 GR 10138元
- 图谱信息:焦碳酸二乙酯(1609-47-8)质谱(MS) 焦碳酸二乙酯(1609-47-8)核磁图( 13 CNMR) 焦碳酸二乙酯(1609-47-8)红外图谱(IR1)
- 用途一:蛋白质组氨酸和酪氨酸的修饰试剂。也是RNA酶的化学修饰剂,它和RNA酶的活性基团组氨酸的咪唑环反应而抑制RNA酶活性。
- MOL 文件:1609-47-8.mol
- 海关编码:29209085
- 检测方法:NMR
- 敏感性:Moisture Sensitive
- Sigma Aldrich:1609-47-8(sigmaaldrich)
- Alfa Aesar:重碳酸二乙酯,97% Diethyl dicarbonate, 97%(1609-47-8)