Diethyl Ethoxymethylenemalonate 乙氧基甲叉丙二酸二乙酯
CAS 87-13-8 MFCD00009148
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资金保障
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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分类
- Pharmaceuticals
- Intermediates & Fine Chemicals
- {SNA} Building Blocks, C10 to C11, Carbonyl Compounds, Chemical Synthesis, Esters, Organic Building Blocks
产品应用
- Intermediate in the production of Flumequine
相关文献及参考
- Sato, M., et al.: J. Med. Chem., 52, 4869 (2009),
- Has been used for the protection of the amino group of ɑ-amino acids, allowing clean esterification by O-alkylation. The protecting group can be removed using bromine in chloroform: Synthesis, 544 (1989):
- Stable equivalent of the ɑ-formylmalonate, valuable synthetic building block, particularly in heterocyclic syntheses. Review: Adv. Het. Chem., 54, (1992).
- For N-protection of aminoglycosides prior to O-acetylation, see: J. Carbohydr. Chem., 14, 1133 (1995). Chlorine in chloroform at 0oC was used for deprotection.
- Can be converted to the unstable diethyl methylenemalonate by catalytic reduction and elimination of ethanol on distillation, see: Org. Synth. Coll., 4, 298 (1963).
安全信息
GHS Symbol
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- R22 Harmful if swallowed 吞咽有害
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
- R42/43
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P312+P330
- P302+P352+P332+P313+P362+P364
- P305+P351+P338
- P305+P351+P338+P337+P313
- P332+P313
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H315 Causes skin irritation 会刺激皮肤
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H302 Harmful if swallowed 吞食有害
- H319 Causes serious eye irritation 严重刺激眼睛
TYPE OF TEST : LCLo - Lowest published lethal concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 44 mg/m3 TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NDRC** National Defense Research Committee, Office of Scientific Research and Development, Progress Report. Volume(issue)/page/year: 30101,11,1945
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2227 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 60,1810,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 925 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes REFERENCE : ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,37,1990
其他信息
- 用途一:一种分子中含有多种活性基团的重要有机原料,能与多种物质进行缩聚和环化缩合,现主要用于合成氟哌酸
- Acros Organics:乙氧基亚甲基丙二酸二乙酯 Diethyl ethoxymethylenemalonate, 99+%(87-13-8)
- 方法一:将原甲酸三乙酯、醋酐、丙二酸二乙酯和无水氧化锌的混合物搅拌加热,在102-115℃保温2.5h,在115-127℃保温7h,再补加部分醋酐和原甲酸三乙酯,继续升温至127-145℃保温2h,145-155℃保温2h。然后将反应物冷至室温,过滤。滤液减压蒸馏,收集108-110℃(33Pa)馏分,得成品,收率50-60%。
- 乙氧基甲叉丙二酸二乙酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 E0255 乙氧基亚甲基丙二酸二乙酯 Diethyl Ethoxymethylenemalonate 25ML 102元 2014/06/02 E0255 乙氧基亚甲基丙二酸二乙酯 Diethyl Ethoxymethylenemalonate 500ML 650元 2010/06/21 114345000 乙氧基甲叉丙二酸二乙酯 Diethyl ethoxymethylenemalonate 99+% 500 GR 904元
- 海关编码:29189090
- Intermediate for the production of Flumequine.
- Alfa Aesar:乙氧亚甲基丙二酸二乙酯,98+% Diethyl ethoxymethylenemalonate, 98+%(87-13-8)
- 上游原料:原甲酸三乙酯 --> 丙二酸二乙酯
- TCI Shanghai:乙氧基亚甲基丙二酸二乙酯 Diethyl Ethoxymethylenemalonate,>;98.0%(GC)(87-13-8)
- 图谱信息:乙氧基甲叉丙二酸二乙酯(87-13-8)质谱(MS) 乙氧基甲叉丙二酸二乙酯(87-13-8)红外图谱(IR1) 乙氧基甲叉丙二酸二乙酯(87-13-8)核磁图( 1 HNMR)
- MSDS 信息:Diethyl ethoxymethylenemalonate(87-13-8).msds
- Sigma Aldrich:87-13-8(sigmaaldrich)
- 下游产品:氟哌酸 --> 甲草胺 --> 洛美沙星 --> 乳清酸 --> 2-三氟甲基-4-氯嘧啶-5-羧酸乙酯 --> 2-甲基巯基-4-氨基嘧啶-5-甲酸乙酯 --> 4-氯-2-甲硫基嘧啶-5-羧酸乙酯 --> 5,6,7,8-四氢吡啶并[4,3-D]嘧啶-4(3H)-酮 --> 左氧氟沙星 --> 7-三氟甲基-4-硫醇喹啉 --> 1,4-二氢-2-甲巯基-4-氧代-5-嘧啶甲酸乙酯 --> 7-溴-3,4-二氢-4-羰基喹啉-3-羧酸 --> 7-(三氯甲基)-4-羟基喹啉 --> 氟罗沙星 --> 2-甲基-4-羟基嘧啶-5-羧酸乙酯 --> 萘啶酸 --> 2-苯基-4-羟基嘧啶-5-羧酸 --> 3,4-二氢-8-羟基-4-羰基喹啉-3-羧酸 --> 7-溴-3,4-二氢-4-羰基喹啉-3-羧酸乙酯 --> 4-羟基-8-甲氧基喹啉-3-羧酸 --> 6-氯-1,2,4-三唑并[4,3-B]哒嗪 --> 2-苯基-4-羟基嘧啶-5-羧酸乙酯 --> 癸氧喹酯 --> 4-羟基-8-甲氧基喹啉-3-羧酸乙酯
- MOL 文件:87-13-8.mol
- 用途二:有机合成原料,用于医药、染料等产品制造。