2,5-Dioxopyrrolidin-1-Yl 3-(Pyridin-2-Yldisulfanyl)Propanoate 3-(2-吡啶基二硫基)丙酸N-羟基琥珀酰亚胺酯
CAS 68181-17-9 MFCD00009636
化学结构图
SMILES: O=C(CCSSC1C=CC=CN=1)ON1C(=O)CCC1=O
化学属性
| Mol. Formula | C12H12N2O4S2 |
|---|---|
| Mol. Weight | 312 |
| Melting Point | 84-86 |
| Appearance | powder |
| Solubility | acetone: 50 mg/mL |
别名和识别编码
| Chemical Name | 2,5-Dioxopyrrolidin-1-Yl 3-(Pyridin-2-Yldisulfanyl)Propanoate |
|---|---|
| CAS Number | 68181-17-9 |
| Synonym | 1-[1-Oxo-3-(2-pyridinyldithio)propyloxy]-2,5-pyrrolidinedione 3-(2-PYRIDYLDITHIO)PROPIONIC ACID*N-HYDR OXYSUCCINIM N-Succinimidyl 3-(2-pyridyldithio)propionate SPDP succinimidyl3-(2-pyridyldithio)propionate(spdp) |
| PubChem Substance ID | 87561636 |
| EC Number | 269-034-3 |
| Beilstein Registry Number | 1548137 |
| MDL Number | MFCD00009636 |
| Reaxys-RN | 1548137 |
| Chemical Name Translation | 3-(2-吡啶基二硫基)丙酸N-羟基琥珀酰亚胺酯 |
| LabNetwork Molecule ID | LN01294861 |
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分类
- {SA} Chemical Biology, Chemical Synthesis, Crosslinkers, Crosslinking, Crosslinking Reagents, Heterobifunctional Cross-Linking Reagents, Heterobifunctional Crosslinking Reagents, Linkers and Crosslinkers, Protein Interaction, Protein Modification, Protein Structural Analysis, Proteomic
- {SNA} Chemical Biology, Chemical Synthesis, Crosslinkers, Crosslinking, Crosslinking Reagents, Heterobifunctional Cross-Linking Reagents, Heterobifunctional Crosslinking Reagents, Linkers and Crosslinkers, Molecular Biology, Protein Interaction, Protein Modification, Protein Structural Analysis,
- {SNA} Chemical Biolo
产品应用
- A heterobifunctional cross-linker.
相关文献及参考
- Carlsson, J. et al.: Biochem. J., 173, 723 (1978),
- Carlsson, J., et al., Protein thiolation and reversible protein-protein conjugation. N-Succinimidyl 3-(2-pyridyldithio)propionate, a new heterobifunctional reagent. Biochem. J. 173 , 723-737, (1978) 摘要
- Na, D.H., et al., Quantitative analysis of derivatized proteins prepared with pyridyl disulfide-containing cross-linkers by high-performance liquid chromatography. Bioconjug. Chem. 10 , 306-310, (1999) 摘要
- Corp MSDS 1 (2), 3004:D / FT-IR 2 (3), 3746:C / RegBook 1 (2), 2519:A / Sigma FT-IR 1 (2), 872:C / Structure Index 1 , 397:A:7
安全信息
GHS Symbol
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P305+P351+P338
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
