2-(2-Methyl-5-nitro-1-imidazolyl)ethanol 2-甲基-5-硝基咪唑-1-乙醇
CAS 443-48-1 MFCD00009750
信息真实价格透明
资金保障
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信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics G-M, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Antiparasitic / Antiprotozoal / Anthelminthic, Biochemicals and Reagents, Chemical Structure Class, Imidazoles, Interferes with DNA Synthesis, L - Z, M, METI - MZ, Mechanism of Action, Spectrum of Activity, 分析/色谱
- {SNA} Antibacterial, A
- {SNA} Antibacterial, Antibiotics A to Z, Antibiotics G-M, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics,
产品应用
- Used as an antibacterial in the treatment of rosacea. Antiprotozoal (trichomonas). A potential human carcinogen.
相关文献及参考
- Carballo, M., et al.: J. App. Toxicol., 29, 248 (2009),
- Merck: 14,6157 Beilstein: 23,V,5,63
- Sanderson, H., et al.: Toxicol. Lett., 187, 84 (2009),
- Leitsch, D., et al.: Mol. Microbiol., 72, 518 (2009),
- Merck: 14,6157
安全信息
GHS Symbol
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
- R45 May cause cancer 可能致癌
- R46 May cause inheritable genetic damage 可能引起遗传基因损害
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- P308+P313
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H303 May be harmfully swallowed 吞食可能有害
- H351 Suspected of causing cancer 怀疑致癌
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 181 gm/kg/72W-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - lymphoma, including Hodgkin's disease REFERENCE : JNCIAM Journal of the National Cancer Instit
TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3 gm/kg/14W-C TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors REFERENCE : TUMOAB Tumori. (Casa Editrice Amb
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 219 gm/kg/2Y-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Skin and Appendages - tumors REFERENCE : JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 63,863,1979
TYPE OF TEST : T
TYPE OF TEST : TD - Toxic dose (othe
TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1680 mg/kg female 1-21 day(s) after conception TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Reproductive - Tumorigenic effects - transplacental tumorigenesis Lungs, Thorax, or Respiration - tumors REFERENCE : JCROD7 Journal of Cancer Research and Clinical Oncology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.93- 1979- Volume(issue)/page/year: 112,135,1986
TYPE OF TEST :
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 40 mg/kg TOXIC EFFECTS : Behavioral - hallucinations, distorted perceptions REFERENCE : SMJOAV Southern Medical Journal. (Southern Medical Assoc., POB 2446, Birmingham, AL 35205) V.1- 1908- Volume(issue)/page/year: 78,627,1985
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3640 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,1089,1974
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 12 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - tremor REFERENCE : BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 292,174,1986
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3800 mg/kg TOXIC EFFECTS : Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 20
TYPE OF TEST : DNA repair TEST SYSTEM : Bacteria - Bacillus subtilis DOSE/DURATION : 200 ug/disc REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 97,1,1982
TYPE OF TEST : Phage inhibition capacity TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 500 ug/plate REFERENCE : AMPOAX Acta Microbiologica Polonica. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1-17(4), 1952-68; V.25- 1976- Volume(issue)/page/year: 34,111,1985
TYPE OF TEST : DNA inhibition TEST SYSTEM : Microorganism - not otherwise specified DOSE/DURATION : 5 mg/L REFERENCE : BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 23,1421,1974
TYPE OF TEST : DNA damage TEST SYSTEM : Rodent - rat Liver DOSE/DURATION : 3 mmol/L REFERENCE : SinJF# Personal Communication from J.F. Sina, Merck Institute for Therapeutic Research, West Point, PA 19486, Oct. 26, 1982 Volume(issue)/page/year: 26OCT1982
TYPE OF TEST : Body fluid assay TEST SYSTEM : Human Bacteria - Salmonella typhimurium DOSE/DURATION : 10 mg/kg REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 77,357,1980
TYPE OF TEST : DNA inhibition TEST SYSTEM : Microorganism - not otherwise specified DOSE/DURATION : 1 mg/L REFERENCE : BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 23,1421,1974
{hazard_com
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 22400 mg/kg SEX/DURATION : male 56 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct REFERENCE : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 12,386,1989
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE : 60 mg/kg SEX/DURATION : female 8-14 day(s) afte
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - rat DOSE : 750 mg/kg SEX/DURATION : female 30 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - uterus, cervix, vagina REFERENCE : RPHRA6 Recent Progress In Hormone Research. Proceedings of the Laurentian Hormone Conference. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1947- Volume(issue)/page/year: 20,395,1964
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 16800 mg/kg SEX/DURATION : male 42 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) REFERENCE : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 12,386,1989
其他信息
- 稳定性:Stable. Incompatible with strong oxidizing agents.
- 毒害物质数据:443-48-1(Hazardous Substances Data)
- MOL 文件:443-48-1.mol
- RTECS号:NI5600000
- F:8
- EPA化学物质信息:1H-Imidazole-1-ethanol, 2-methyl-5-nitro-(443-48-1)
- 硝基咪唑类抗生素:甲硝唑是一种硝基咪唑类抗生素,又叫灭滴灵、甲硝哒唑、甲硝基羟乙唑、灭滴唑,对厌氧微生物有杀灭作用,它在人体中还原时生成的代谢物也具有抗厌氧菌作用,抑制细菌的脱氧核糖核酸的合成,从而干扰细菌的生长、繁殖,最终致细菌死亡,抗厌氧菌普包括:脆弱拟杆菌、梭形杆菌(由于菌体形态两端尖锐呈梭形而得名)、破伤风杆菌、消化球菌、消化链球菌、贾第鞭毛虫菌。最初被用于治疗阴道滴虫病,临床效果非常显著。后来人们发现,甲硝唑也可以杀灭引起口腔感染的厌氧菌,1978年被世界卫生组织将其确定为抗厌氧菌感染的特效药物,广泛应用于预防和治疗口腔厌氧菌感染。在医院本品也经常被用于预防和治疗因厌氧菌引起的呼吸道,消化道,腹腔及盆腔感染,皮肤软组织及骨关节感染,心膜炎,败血症和脑的治疗。 甲硝唑对体内组织及肠腔内的阿米巴病的疗效显著,也是人体治疗虫病的首选药物,作用机理是通过抑制阿米巴原虫的氧化还原反应,使原虫氮链发生断裂而起作用。体外试验证明,药物浓度为1~2mg/L时,溶组织阿米巴于6 ~20小时即可发生形态改变,24小时内全部被杀灭,浓度为0.2mg/L的,72小时内可杀死溶组织阿米巴,目前已经广泛用于治疗肠道和肠外阿米巴病(如阿米巴肝脓肿、胸膜阿米巴病等)。 由于硝基咪唑类抗生素和乙醇、尼古丁等有相互作用,干扰乙醇的氧化过程,能引起双硫仑反应,导致心率较快、血压降低等症状,所以患者服药期间,应避免接触含酒精的饮品,少抽烟,以避免药物不良反应的发生。
- 图谱信息:甲硝唑(443-48-1)红外图谱(IR1) 甲硝唑(443-48-1)核磁图( 1 HNMR) 甲硝唑(443-48-1)红外图谱(IR2) 甲硝唑(443-48-1)核磁图( 13 CNMR) 甲硝唑(443-48-1)质谱(MS)
- 溶于热水,略溶于乙醇,微溶于水或氯仿,极微溶于乙醇。味苦而略咸。
- NIST化学物质信息:Metronidazole(443-48-1)
- 生产方法:由2-甲基-5-硝基咪唑(见25010)与环氧乙烷加成而得。将2-甲基-5-硝基咪唑溶解于甲酸中,在30-40℃逐次加入环氧乙烷,并在加料中间加硫酸。加毕,反应1h。减压回收甲酸,加水溶解后冷却至10℃,过滤。滤液用氢氧化钠溶液调至pH=10,放置冷却,过滤,水洗至近中改建。用水重结晶。活性炭脱色,即得甲硝唑。
- 甲硝唑价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 M0924 2-甲基-5-硝基咪唑-1-乙醇 2-Methyl-5-nitroimidazole-1-ethanol 25G 495元 2014/06/02 M0924 2-甲基-5-硝基咪唑-1-乙醇 2-Methyl-5-nitroimidazole-1-ethanol 500G 4310元 2010/06/21 BTB09707EE 甲硝唑 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethan-1-ol 50 GR 915元
- 用途:用于治疗阿米巴病、滴虫病及厌氧菌感染