Acetohydroxamic acid 乙酰氧肟酸
CAS 546-88-3 MFCD00009994
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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分类
- {SNA} Analytical S
- {SNA} A-AM, Building Blocks, Chemical Synthesis,
- {SNA} Building Blocks, Chemical Synthesis, Hydroxylamines, Nitrogen Compounds, Organic Building Blocks
- Inhibitors
- {SNA} Analytical Standards, Chromatography, Pharmaceutical Standards, Pharmacopeia Standards, USP Standards, USP Standards
产品应用
- 本品医药上是尿酶竞争抑制剂,用于尿肾结石等病症治疗;牧业上用于提高饲料蛋白质转化率 。也用于制备其它药物。
相关文献及参考
- Short: III/35E
- Short: III/31a
- Xiao, Z.-P., et al.:
- Merck:14,63 Beilstein:2,187
- Merck:14,63
安全信息
GHS Symbol
- H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
- P203
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- P308+P313
- P318
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
- S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
- R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 92 660,1956
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,645,1968
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 5 umol/plate REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 172,199,1986
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 20 mmol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 152,225,1985
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 160 umol/plate REFERENCE : JOPHDQ Journal of Pharmacobio-Dynamics. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1978- Volume(issue)/page/year: 3,557,1980
TYPE OF TEST : DNA repair TEST SYSTEM : Bacteria - Bacillus subtilis DOSE/DURATION : 250 umol/disc REFERENCE : JOPHDQ Journal of Pharmacobio-Dynamics. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1978- Volume(issue)/page/year: 3,557,1980
TYPE OF TEST : Unscheduled DNA synthesis TEST SYSTEM : Rodent - rat Liver DOSE/DURATION : 2500 umol/L REFERENCE : PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987- Volume(issue)/page/year: 60,9,1987
TYPE OF TEST : DNA damage TEST SYSTEM : Rodent - rat Liver DOSE/DURATION : 10 mmol/L REFERENCE : PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 19
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE : 750 mg/kg SEX/DURATION : female 12 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : JMXSAE Journal of Maxillofacial Surgery. (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart 1, Fed. Rep. Ger.) 1973- Volume(issue)/page/year: 2,230,1974
其他信息
- Sigma Aldrich:546-88-3(sigmaaldrich)
- 储运特性:库房通风低温干燥
- 图谱信息:乙酰氧肟酸(546-88-3)红外图谱(IR2) 乙酰氧肟酸(546-88-3)红外图谱(IR1) 乙酰氧肟酸(546-88-3)质谱(MS) 乙酰氧肟酸(546-88-3)Raman光谱
- 毒性分级:中毒
- 用途一:原为USP收载用于治疗细菌性胆,肾结石及肝昏迷等症.由于良好的瘤胃微生物脲酶抑制作用,英、美等国于上世纪九十年代初始用于牛、羊等反刍动物营养,以改善瘤胃氨环境,提高蛋白质的转化率,增加粗饲料采食量,降低血液氨浓度,减轻氨应激,增加机体免疫力,收到良好效果.
- 几乎无臭;味微苦;遇光变色;易吸潮;易溶于水、无水乙醇;水溶液呈调酸性反应。
- 用途二:本品医药上是尿酶竞争抑制剂,用于尿肾结石等病症治疗;牧业上用于提高饲料蛋白质转化率 。也用于制备其它药物。
- 急性毒性:腹腔-小鼠 LD50:1300 毫克/公斤
- 乙酰氧肟酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xw010089 乙酰氧肟酸 5g 320元 2011/04/16 A0051 乙酰氧肟酸 Acetohydroxamic Acid 25G 1450元 2011/04/16 A0051 乙酰氧肟酸 Acetohydroxamic Acid 10G 734元
- Hazard Note:Toxic
- 灭火剂:干粉、泡沫、砂土、二氧化碳, 雾状水
- 外观性质:白色结晶或结晶性粉末,几乎无臭;味微苦;遇光变色;易吸潮;易溶于水、无水乙醇;水溶液呈调酸性反应。熔点:86-90°C
- Acros Organics:乙酰氧肟酸 Acetohydroxamic acid, 98+%(546-88-3)
- MOL 文件:546-88-3.mol
- TCI Shanghai:乙酰氧肟酸 Acetohydroxamic Acid,>;95.0%(T)(546-88-3)
- MSDS 信息:Acetohydroxamic acid(546-88-3).msds
- 可燃性危险特性:可燃; 加热分解释放有毒氮氧化物烟雾
- 类别:有毒物品
- Alfa Aesar:乙酰羟肟酸,98% Acetohydroxamic acid, 98%(546-88-3)
- 敏感性:Hygroscopic