CAS 519-23-3 MFCD00010524-5,11-Dimethyl-6H-Pyrido[4,3-B]Carbazole 5,11-二甲基-6H-吡啶并[4,3-b]咔唑 TAO{mole}

5,11-Dimethyl-6H-Pyrido[4,3-B]Carbazole 5,11-二甲基-6H-吡啶并[4,3-b]咔唑

CAS 519-23-3 MFCD00010524

化学结构图

SMILES: Cc1c2ccncc2c(C)c2c1[nH]c1ccccc12

化学属性

Mol. Formula	C17H14N2
Mol. Weight	246
Melting Point	316-318°C
Solubility	Soluble in DMSO, not in water
Appearance	Yellow solid powder

别名和识别编码

Chemical Name	5,11-Dimethyl-6H-Pyrido[4,3-B]Carbazole
MDL Number	MFCD00010524
CAS Number	519-23-3
Synonym	3-b)carbazole,5,11-dimethyl-6h-pyrido( 5,11-DIMETHYL-6H-PYRIDO[4,3-B]CARBAZOLE 5,11-DIMETHYLPYRIDO[4,3-B]CARBAZOLE 5,11-DIMETHYLPYRIDO[4.3:B]CARBAZOLE 5,11-Dimethyl-6H-pyrido(4,3-b)carbazole 5,11-dimethyl-6H-pyrido(4,3-b)carbazole 5,11-二甲基-6H-吡啶并[4,3-b]咔唑 CCG-36483; CCG36483; CCG 36483; DB-052047; K00071; LP00531; LS-133282; NSC 71795; NSC71795; NSC-71795; TCMDC-125546; VZ29809; Elliptecine; Ellipticine; Elliptisine. CP 5 CP-3025 ELLIPTICIN ELLIPTICINE ELLIPTICINE(RG) ELLIPTICINE, FOR FLUORESCENCE Ellipticine ICIG 770 NSC 71795 NSC-71795 PYRIDO(4,3-B)CARBAZOLE,5,11-DIMETHYL- ellipticine ellipticine hydrochloride ellipticine tartrate icig770 椭圆玫瑰树碱 {Chemicalbook
PubChem Substance ID	3213
EC Number	208-264-0
Beilstein Registry Number	0221300
Chemical Name Translation	5,11-二甲基-6H-吡啶并[4,3-b]咔唑
Merck Number	13,3581
Wiswesser Line Notation	T D6 B656 FN LMJ C1 J1
Formula	C17H14N2
IUPAC Name	5,11-dimethyl-6H-pyrido[4,3-b]carbazole
InChIKey	CTSPAMFJBXKSOY-UHFFFAOYSA-N
InChI	InChI=1S/C17H14N2/c1-10-14-9-18-8-7-12(14)11(2)17-16(10)13-5-3-4-6-15(13)19-17/h3-9,19H,1-2H3
Canonical SMILES	CC1=C(C=NC=C2)C2=C(C)C(N3)=C1C4=C3C=CC=C4

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分类

{SA} A to C, Apoptosis and Cell Cycle, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Cytochrome P450 (CYP1A1)and DNA topoisomerase II, DNA Repair Regulators, DNA metabolism, E, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, R to Z, Topoisomerase II
{SNA} Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, E, Fluorescent Probes, Labels, Particles and Stains, Fluorescent Stains, Nucleic Acid Stains, Nucleic Acid Stains For Flow Cytometry

产品应用

Ellipticine is a DNA intercalating agent and a DNA topoisomerase II inhibitor. Ellipticine is also a natural product, isolated in 1959 from the Australian evergreen tree of the Apocynaceae family. Ellipticine was found to be an extremely promising anticancer drug. The planar polycyclic structure was found to interact with DNA through intercalation, exhibiting a high DNA binding affinity (10(6) M(-1)). The presence of protonatable ring nitrogens distinguished ellipticine from other simple intercalators. Both monocationic and uncharged species were found to be present under physiological conditions. The positive charge stabilized the binding of ellipticine to nucleic acids, while the more lipophilic uncharged compound was shown to readily penetrate membrane barriers. The structural nature of these compounds offers a plausible basis for the implication of multiple modes of action, including DNA binding, interactions with membrane barriers, oxidative bioactivation and modification of enzym

安全信息

GHS Symbol

WGK Germany3

Hazard statements

H301 Toxic if swallowed 吞食有毒

Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

RTECSUU8825000

Precautionary statements

P301+P310

Signal word Danger

Packing GroupIII

Hazard Codes T

Hazard Class6.1(b)

Storage condition 2-8°C Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

UN Number UN 3462 6.1/PG 3

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；

Risk Statements

R25 Toxic if swallowed 吞咽有毒

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 178 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals",
   11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year:
   11,555,1989

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BIMDB3 Biomedicine.  (Paris, France)  V.18-34, 1973-81.
   Volume(issue)/page/year: 21,101,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 19500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals",
   11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year:
   11,555,1989

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 20 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 311,21,1994

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 50 ug/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 9,161,1987

{haz

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 ug/plate
REFERENCE :
   BICMBE Biochimie.  (SPPIF, B.P.22, F-41353 Vineuil, France)  V.53-    1971-
   Volume(issue)/page/year: 60,1011,1978

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 10 mg/L
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 30,1204,1987

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 20 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 311,21,1994

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 12500 nmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 243,213,1990

TYPE OF TEST            : DNA adduc

其他信息

MOL 文件:519-23-3.mol
Sigma Aldrich:519-23-3(sigmaaldrich)