Fluocinolone Acetonide 氟氢松
CAS 67-73-2 MFCD00010525
信息真实价格透明
资金保障
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信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Chemical Structure, Chromatography, Drugs & Metabolites, Drugs of Abuse, F, FA - FL, Forensic and Veterinary Standards, Neat Compounds, Steroid
- {SNA} Additional Standards, Analytical Standards, Chemical Structure, Chromatography, Drugs & Metabolites, Drugs of Abuse, Forensic and Veterinary Standards, Neat Compounds, Steroid, 分析/色谱
- {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Chemical Structure, Chromatography,
产品应用
- A synthetic glucocorticoid VEGF inhibitor.
相关文献及参考
- [2]. Nehme, A., et al., Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells. BMC Med Genomics, 2009. 2: p. 58.
- Emerson, M.V., et al.: BioDrugs, 21, 245 (2007),
- Sammul, et al.: J. Assoc. Off. Agric. Chem., 47, 952 (1964),
- [1]. http://en.wikipedia.org/wiki/Fluocinolone_acetonide
- [1]. http://en.wikipedia.org/wiki/Fluocinolone_acetonide
- [2]. Nehme, A., et al., Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells. BMC Med Genomics, 2009. 2: p. 58.
安全信息
GHS Symbol
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P332+P313
- P302+P350
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- P337+P313
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
- S37 Wear suitable gloves 戴适当手套;
- S22 Do not breathe dust 不要吸入粉尘;
- S36 Wear suitable protective clothing 穿戴适当的防护服;
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 103 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs).
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 108 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,694,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >4 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,694,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 42 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,694,1982
TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - rat Embryo DOSE/DURATION : 10 gm/L REFERENCE : CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 4,653,1983
TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 500 nmol/L REFERENCE : BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 19,1471,1970
TYPE OF TEST : DNA inhibition ROUTE OF EXPOSURE : Administration onto the skin TEST SYSTEM : Rodent - mouse DOSE/DURATION : 40 ug/kg REFERENCE : CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 17,331,1977
TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - mouse Lymphocyte DOSE/DURATION : 500 nmol/L REFERENCE : BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 19,1471,1970
TYPE OF TEST : Morphological transformation TEST SYSTEM : Rodent - hamster Embryo DOSE/DURATION : 620 ug/L REFERENCE : AETODY Advances in Modern Environmental Toxicology. (Senate Press, Inc., P.O. Box 252, Princeton Junction, NJ 08550) V.1- 1980- Volume(issue)/page/year: 1,241,1980
TYPE OF TEST : Mutation test systems - not otherwise specified ROUTE OF EXPOSURE : Administration onto the skin TEST SYSTEM : Human DOSE/DURATION : 2000 ppm REFERENCE : ARDEAC Archives of Dermatology.
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 1 mg/kg SEX/DURATION : female 1-20 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,2102,1977
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rabbit DOSE : 1200 ug/kg SEX/DURATION : female 8-31 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - stillbirth REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,2102,1977
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rabbit DOSE : 1625 ug/kg SEX/DURATION : female 6-18 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - abortion REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 37,43,1987
其他信息
- 醋酸肤轻松价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 F0657 乙酸肤轻松 Fluocinolone Acetonide 5G 4330元 2014/06/02 F0657 乙酸肤轻松 Fluocinolone Acetonide 1G 1120元
- 醋酸肤轻松价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 F0657 乙酸肤轻松 Fluocinolone Acetonide 5G 3410元 2011/04/16 F0657 乙酸肤轻松 Fluocinolone Acetonide 1G 971元
- MSDS 信息:6a,9a-Fifluoro-16a,17a-isopropylidenedioxy-1,4-pregnadiene-3,20-dione(67-73-2).msds
- MOL 文件:67-73-2.mol
- 醋酸氟轻松
- Fluocinolone Acetonide是一种皮质类固醇,与胞浆中糖皮质激素受体结合。
- 用途一:用于过敏性皮炎、接触性皮炎、脂溢性皮炎及湿疹等。
- 醋酸氟轻松:醋酸氟轻松为合成的、含氟强效的类固醇。外用可使真皮毛细血管收缩,抑制表皮细胞增殖或再生,抑制结蒂组织内纤维细胞的新生,稳定细胞内溶酶体膜,具有抗炎、止痒的作用。外用后可通过完整的皮肤吸收。吸收后与系统给予皮质类固醇在体内的代谢一样,主要在肝脏代谢,经肾脏排出。醋酸氟轻松适用于对皮质类固醇有效的皮肤病,如湿疹(特别是婴儿湿疹)、神经性皮炎、皮肤瘙痒症、接触性皮炎、牛皮癣、盘状红斑狼疮、扁平苔癣、外耳炎、日光性皮炎等。但需要注意长期或大面积使用可引起皮肤萎缩、毛细血管扩张,发生痤疮样皮炎、口周皮炎、毛囊炎,增加对感染的易感性等。偶可引起变态反应接触性皮炎。
- 理化性质:白色或类白色结晶性粉末,无臭,无味。[α]D20+80—+88° (二氧六环)。溶于丙酮,略溶于乙醇、二氧六环,不溶于水、石油醚。由11α-羟基 -16α,17α-环氧孕甾烷-4-烯-3,20-二酮经磺酯化、开环等16步反应而得。用于过敏性皮炎,接触性皮炎、湿疹等皮肤病。
- 皮质激素类药物:醋酸肤轻松 又称醋酸氟轻松、氟西奈德、氟去炎舒松、肤轻松、氟轻松、仙乃乐、丙酮化氟新龙,为目前我国外用皮质激素中疗效最显著而副作用较小的一种,可使真皮毛细血管收缩,抑制结缔组织细胞增殖或再生;还可稳定细胞内溶酶体膜,防止细胞内溶酶体酶释放组胺而引起组织损伤。其抗炎作用为氢化可的松的100倍,使用最低浓度 (0.025%) 即有明显功效,且奏效迅速、能在数日内显著减轻或痊愈,止痒作用较好。醋酸肤轻松主要用于用于对糖皮质激素有效的皮肤病,如接触性皮炎、特应性皮炎、脂溢性皮炎、神经性皮炎、日光性皮炎、湿疹(特别是婴儿湿疹)、皮肤瘙痒症、银屑病、盘状红斑狼疮、扁平苔藓、外耳炎等。与新霉素等抗菌素配伍可治疗化脓性皮肤病。以0.025-0.05%软膏,洗剂涂于拭净的患部,每日2-3次,可轻揉促其渗入皮肤。
- TCI Shanghai:乙酸肤轻松 Fluocinolone Acetonide,>;98.0%(LC)(67-73-2)
- Sigma Aldrich:67-73-2(sigmaaldrich)