Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate (BOP) 卡特缩合剂
CAS 56602-33-6 MFCD00011948
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资金保障
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分类
- Miscellaneous Reagents
- {SNA} Chemical Biology, Chemical Synthesis, Coupling, Peptide Chemistry, Peptide Coupling, Phosphonium/Uronium/Formamidinium, Synthetic Reagents
产品应用
- Usually used as reagent for Peptide coupling,Synthesis of esters,Esterification of carboxylic acids,Plasmid CAN-encapsulating liposomes,Synthesis of magnolamide for antioxidative activity,Catalyst for preparation of 9-acridinecaroboxamide derivative.
相关文献及参考
- Mild and efficient reagent for the preparation of esters from carboxylic acids and alcohols: Tetrahedron Lett., 36, 4253 (1995); for esterification of amino acids at low temperatures, see: Tetrahedron Lett., 35, 5603 (1994); for use in formation of mixed phosphonate diesters, see: J. Org. Chem., 60, 5214 (1995).
- Reagent for high yield, low racemization peptide coupling: Tetrahedron Lett., 1219 (1975). See Appendix 6.
- Mild and efficient reagent for the p
- Reagent for high yield, low racemization peptide coupling: Tetrahedron Lett., 1219 (1975). See Appendix 6.
- The carboxyphosphonium salts formed by reaction with carboxylic acids can be reduced with NaBH4, providng a mild method for reduction of acids to alcohols: Tetrahedron lett., 39, 3319 (1998).
- Promotes the reaction of aliphatic primary amines with CS2 to give isothiocyanates which can be isolated in high yield or reacted in situ with nucleophiles: J. Chem. Soc., Chem. Commun., 1995 (1995).
- Kenner, G.W., Seely, J., J. Am. Chem. Soc., 94, 3259 (1972),
- 6. W. Chiou, et al., Heterocycles 65 , 1215-1220, (2005)
安全信息
GHS Symbol
- H315 Causes skin irritation 会刺激皮肤
- H228 Flammable solid 易燃固体
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- P332+P313
- P305+P351+P338+P337+P313
- P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
- P302+P350
- P337+P313
- P302+P352+P332+P313+P362+P364
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S37 Wear suitable gloves 戴适当手套;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- R11 Highly flammable 非常易燃
- R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
- R44 Risk of explosion if heated under confinement 密封下加热有爆炸危险
- R2 Risk of explosion by shock, friction, fire or other sources of ignition 遇到震动、摩擦、火焰或者其它引燃物有爆炸危险
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
其他信息
- 在甲醇中25mg/ml,溶液澄清。对光敏感;对潮湿敏感磷正离子型多肽缩合剂[1.2];内酯化及酯化试剂[3.4]。