Amitriptyline Hydrochloride 盐酸阿米替林
CAS 549-18-8 MFCD00012537
化学结构图
SMILES: CN(C)CCC=C1c2ccccc2CCc2ccccc21.Cl
化学属性
| Mol. Formula | C20H24ClN |
|---|---|
| Mol. Weight | 314 |
| Melting Point | 195-199 |
| Solubility | Soluble in Chloroform |
| Flash Point | 11 °C |
| Appearance | 本品为白色结晶性粉末。溶点196-197℃，易溶于水、乙醇、甲醇、氯仿，不溶于乙醚。无臭，味苦。 powder |
| Stability | 对光敏感 |
别名和识别编码
| Chemical Name | Amitriptyline Hydrochloride |
|---|---|
| MDL Number | MFCD00012537 |
| CAS Number | 549-18-8 |
| EC Number | 208-964-6 |
| PubChem Substance ID | 87562417 |
| Synonym | 10,11-dihydro-n,n-dimethyl-5h-dibenzo(a,d)cycloheptene-delta(sup5,gamma)-pro Amitriptyline hydrochloride LABOTEST-BB LT00244837 1-propanamine,3-(10,11-dihydro-5h-dibenzo[a,d]cyclohepten-5-ylidene)-n,n-dimet 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-, hydrochloride (1:1) AMITRIPTYLINE HYDROCHLORIDE 5-(3-dimethylaminopropylidene)dibenzo(a,d)(1,4)cycloheptadienehydrochloride 盐酸阿密曲替啉 damilenhydrochloride endep LABOTEST-BB LT00159907 阿米替林 盐酸盐 AMITRIPTYLINE HCL 3-(10,11-dihydro-5h-dibenzo[a,d]cycloheptene-5-ylidene)-n,n-dimethyl-1-propanamine hydrochloride rantoron 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine 盐酸阿米替林 elavilhydrochloride N,N-二甲基-3-[10,11-二氢-5H-二苯并(a,b)环庚三烯-5-亚基]-1-丙胺盐酸盐;阿密替林;阿米替林盐酸盐 proheptadienmonohydrochloride limbitrolds domical Damilen hydrochloride N,N-二甲基-3-[10,11-二氢-5H-二苯并(a,b)环庚三烯-5-亚基]-1-丙胺盐酸盐 阿米替林盐酸盐 Domical pylaminehcl Deprex 阿密替林 deprex Amitriptyline chloride 10,11-Dihydro-N,N-dimethyl-5H-dibenzo(a,d)cycloheptene-delta(sup etrafon amitriptylinechloride miketorin |
| Chemical Name Translation | 盐酸阿米替林 |
| Merck Number | 487 |
| Reaxys-RN | 4164595 |
| Beilstein Registry Number | 4164595 |
| Alfabeta Name | DIHYDRODIBENZOANNULENYLIDENEDIMETHYLPROPANAMINEHYDROCHLORIDE HADNN310115751[[]]()----------,,, |
| Wiswesser Line Notation | L C676 BY&T&J BU3N1&1 &GH |
| LabNetwork Molecule ID | LN00227108 |
| InChI | InChI=1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H |
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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现货库存
一流品牌服务
分类
- {SNA} A-AM, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Biochemicals and Reagents, Biogenic Amine Transport Inhibitors, Bristol-Myers Squibb, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmission (Obesity),
- {SNA} Additional Standards, Analytical Standards, Chromatography, Pharmaceutical Secondary Standards, Pharmaceutical Standards, 分析/色谱
- {SNA} Analytical Standards, Analytical/Chromatography,
- {SNA} A-AM, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Biogenic Amine Transport Inhibitors, Bri
产品应用
- Amitriptyline hydrochloride is a tricyclic antidepressant drug. Amitriptyline hydrochloride inhibits the norepinephrine and serotonin transporters but has a high affinity for α1-adrenergic, serotonin and muscarinic acetylcholine receptors.
相关文献及参考
- [2]. S Neil Vaishnavi , et al. Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity. Biol Psychiatry. 2004 Feb 1;55(3):320-2.
- [3]. Jang, S.W., et al., Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity. Chem Biol, 2009. 16(6): p. 644-56.
- [1]. Kim Lawson. A Brief Review of the Pharmacology of Amitriptyline and Clinical Outcomes in Treating Fibromyalgia. Biomedicines. 2017 Jun; 5(2): 24.
- [1]. Kim Lawson. A Brief Review of the Pharmacology of Amitriptyline and Clinical Outcomes in Treating Fibromyalgia. Biomedicines. 2017 Jun; 5(2): 24.
- [2]. S Neil Vaishnavi , et al. Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity. Biol Psychiatry. 2004 Feb 1;55(3):320-2.
- [3]. Jang, S.W., et al., Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization an
安全信息
GHS Symbol
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P273 Avoid release to the environment. 避免释放到环境中。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- P301+P310
- P301+P310+P330
- P302+P350
- P305+P351+P338
- P305+P351+P338+P337+P313
- P332+P313
- P337+P313
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
- H319 Causes serious eye irritation 严重刺激眼睛
- H301 Toxic if swallowed 吞食有毒
- H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
- S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
- S22 Do not breathe dust 不要吸入粉尘；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
- R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R42/43
- R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 80 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 6,889,1972
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - child DOSE/DURATION : 4167 ug/kg TOXIC EFFECTS : Behavioral - sleep Behavioral - hallucinations, distorted perceptions Behavioral - muscle contraction or spasticity REFERENCE : NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 267,1031,1962
{hazTYPE OF TEST : LD50 - Lethal do
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 37 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 22,385,1991
TYPE OF TEST :
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - child DOSE/DURATION : 62500 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis REFERENCE : AJDCAI American Journal of Diseases of Children. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1-80(3
TYPE OF TEST : Sperm Morphology ROUTE OF EXPOSURE : Oral TEST SYSTEM : Rodent - mouse DOSE/DURATION : 70 mg/kg/5D REFERENCE : IMSCE2 IRCS Medical Science. (Lancaster, UK) V.12-14, 1984-86. For publisher information, see MSCREJ. Volume(issue)/page/year: 14,579,1986
TYPE OF TEST : Sex chromosome loss and nondisjunction ROUTE OF EXPOSURE : Oral TEST SYSTEM : Insect - Drosophila melanogaster DOSE/DURATION : 2 mg/2D REFERENCE : SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.2- 1966- Volume(issue)/page/year: 11,718,1975
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE : 60 mg/kg SEX/DURATION : female 9 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) REFERENCE : DGDFA5 Development, Growth & Differentiation. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.11- 1969- Volume(issue)/page/year: 22,61,1980
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 220 mg/kg SEX/DURATION : female 1-22 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - behavioral REFERENCE : BRBUDU Brain Research Bulletin. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1976- Volume(issue)/page/year: 24,207,1990
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE : 70 mg/kg SEX/DURATION : male 5 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) REFERENCE : IMSCE2 IRCS Medical Science. (Lancaster, UK) V.12-14, 1984-86. For publisher information, see MSCREJ. Volume(issue)/page/year: 14,579,1986
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE : 60 mg/kg SEX/DURATION : female 9 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (ex
其他信息
- 盐酸阿米替林价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 A0908 盐酸阿米替林 Amitriptyline Hydrochloride 25G 945元
- 图谱信息:盐酸阿米替林(549-18-8)质谱(MS) 盐酸阿米替林(549-18-8)红外图谱(IR1) 盐酸阿米替林(549-18-8)红外图谱(IR2)
- TCI Shanghai:盐酸阿米替林 Amitriptyline Hydrochloride,>;98.0%(LC)(T)(549-18-8)
- 用途一:本品为抗抑郁药，具有抗抑郁作用和较强的镇静作用。主要用于内源性外源性抑郁症状、更年期忧郁症、神经性抑郁症及器质性精神病的抑郁症状，也可用于儿童和少年的遗尿症。
- 阿米替林 盐酸盐
- 上游原料:乙醚 --> 氯化铵 --> 五氧化二磷 --> 稀盐酸 --> 二乙烯酮 --> 苯乙酸 --> 阿米替林
- 方法一:由二苯并[α,d]环庚二烯酮-（5）经加成、消除、成盐而得。将干燥镁片及乙醚投入反应罐，加热回流。先滴加二甲胺基氯丙烷的乙醚溶液，再滴加二苯并环庚二烯酮的乙醚溶液。回流蒸出乙醚，加甲苯，冷却后加饱和氯化铵水溶液。停止搅拌，分出甲苯液，再用甲苯对水层提取5次。合并甲苯液，用温水洗3次，用无水硫酸钠干燥，过滤。滤液回收甲苯后得羟基阿米替林粗品。将粗品用甲苯和活性炭重结晶精制后，搅拌加热下溶解于浓盐酸，回流2-3小时后，减压蒸出稀盐酸至干。加异丙醇及活性炭，升温搅拌回流1小时。趁热过滤，在搅拌下滤液缓缓冷却，结晶，过滤，烘干，得阿米替林盐酸盐。收率约为75%。
- color:white to off-white
- Amitriptyline inhibits serotonin receptor, norepinephrine receptor, 5-HT4, 5-HT2 and sigma 1 receptor with IC50 of 3.45 nM, 13.3 nM, 7.31 nM, 235 nM and 287 nM, respectively.
- MOL 文件:549-18-8.mol
- Sigma Aldrich:549-18-8(sigmaaldrich)
