CAS 61-12-1 MFCD00012735-Dibucaine hydrochloride 盐酸辛可卡因 TAO{mole}

Dibucaine hydrochloride 盐酸辛可卡因

CAS 61-12-1 MFCD00012735

化学结构图

SMILES:

化学属性

Mol. Formula	C20H29N3O2.ClH
Mol. Weight	379.98
Melting Point	99-101 °C(lit.)
Appearance	白色结晶性粉末。熔点94-96℃。易溶于水（1份该品溶于0.5份水），极易溶于乙醇、丙酮、氯仿，微溶于苯，不溶于醚。味略苦，有潮解性，遇光变质。

别名和识别编码

Chemical Name	Dibucaine hydrochloride
CAS Number	61-12-1
Synonym	2-丁氧基-N-(2-二乙氨乙基)-4-喹啉甲酰胺盐酸盐 2-BUTOXY-N-[2-(DIETHYLAMINO)ETHYL]CINCHONINAMIDE HYDROCHLORIDE Cinchocaine hydrochloride A-BUTYLOXYCINCHONINIC ACID DIETHYLETHYLENEDIAMIDE HYDROCHLORIDE {Chemical 2-butoxy-n-(2-(diethylamino)ethyl)-cinchoninamidmonohydrochloride Cincaine hydrochloride 2-BUTOXY-N-[2-(DIETHYLAMINO)ETHYL 狄布卡因 2-Butoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide monohydrochloride; 2-Butoxy-N-(2-diethylaminoethyl)cinchoninamide hydrochloride Cincaine Chloride cincainehydrochloride Dibucaine hydrochloride 2-BUTOXY-N-(2-DIETHYLAMINOETHYL)-4-QUINOLINECARBOXAMIDE HYDROCHLORIDE 狄布卡因盐酸盐 Benzolin butoxycinchoninicaciddiethylethylenedi 2-n-butoxy-n-(2-diethylaminoethyl)cinchoninamidehydrochloride Nupercaine Hydrochloride cincainechloride 盐酸狄布卡因 4-Quinolinecarboxamide,2-butoxy-N-[2-(diethylamino)ethyl]-,monohydrochloride 2-丁氧基-N-(2-二乙氨乙基)-4-喹啉甲酰胺盐酸盐 Cinchocaine hydrochloride NUPERCAINE HYDROCHLORIDE c3225 4-Quinolinecarboxamide, 2-butoxy-N-[2-(diethylamino)ethyl]-, monohydrochloride 4-Quinolinecarboxamide, 2-butoxy-N-(2-(diethylamino)ethyl)-, CINCHOCAINE HYDROCHLORIDE 2-Butoxy-N-(2-diethylaminoethyl)cinchoninic acid amide hydrochloride cinchocainiumchlorid 狄布卡因盐酸盐 b 沙夫卡因 2-butoxy-n-(2-diethylaminoethyl)cinchoninicacidamidehydrochloride 拍卡因 2-butoxy-n-(2-(diethylamino)ethyl)-4-quinolinecarboxamidmonohydrochlorid c Percamin S 2-Butoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide Hydrochloride 2
MDL Number	MFCD00012735
PubChem Substance ID	24893282
EC Number	200-498-1
Chemical Name Translation	盐酸辛可卡因
Merck Number	13,3057
Wiswesser Line Notation	T66 BNJ CO4 EVM2N2&2 &GH

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产品应用

Anesthetic (local).

安全信息

WGK Germany3

GHS Symbol

Precautionary statements

P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P305+P351+P338

Signal word Danger

Hazard statements

H318 Causes serious eye damage 严重伤害眼睛
H302 Harmful if swallowed 吞食有害

Hazard Codes Xn

RTECSGD3325000

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Safety Statements

S39 Wear eye/face protection 戴眼睛/面孔保护装置；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；

Risk Statements

R22 Harmful if swallowed 吞咽有害
R41 Risk of serious damage to eyes 有严重损伤眼睛的危险

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EJPHAZ European Journal of Pharmacology.  (Elsevier Science Pub. B.V., POB
   211, 1000 AE Amsterdam, Netherlands)  V.1-    1967- Volume(issue)/page/year:
   3,58,1968

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 29 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 94,299,1948

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 15300 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   QJPPAL Quarterly Journal of Pharmacy & Pharmacology.  (London, UK)  V.2-21,
   1929-48.  For publisher information, see JPPMAB.  Volume(issue)/page/year:
   20,380,1947

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraspinal
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 57,221,1936

{hazar

TYPE OF TEST            : LD50 - Lethal dose, 5

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 15 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 89,95,1981

其他信息

用途一:用作局部麻醉药
MOL 文件:61-12-1.mol
用途二:该品属酰胺类麻醉药，临床应用的局麻药中，辛可卡因是作用最强、毒性最大、维持时间最长的一种。注射给药的麻醉强度是普鲁卡因的15倍，毒性也大15倍。起效较慢，约15min，但持续作用时间为普鲁卡因的3倍。局部刺激性小，穿透力较强。用于表面麻醉、浸润麻醉或硬脊膜外麻醉。
方法一:2-羟基喹啉羧酸经氯化、缩合、丁醚化、成盐得到辛可卡因。
上游原料:二丁醚 --> 3-甲氧基丙酸 --> 2-羟基喹啉 --> 辛可卡因
Sigma Aldrich:61-12-1(sigmaaldrich)
MSDS 信息:2-Butoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide monohydrochloride(61-12-1).msds