CAS 23007-85-4 MFCD00012790-1-Methyl-4-Phenyl-1，2，3，6-Tetrahydropyridinehydrochloride 1-甲基-4-苯基-1,2,3,6-四氢吡啶盐酸盐 TAO{mole}

1-Methyl-4-Phenyl-1，2，3，6-Tetrahydropyridinehydrochloride 1-甲基-4-苯基-1,2,3,6-四氢吡啶盐酸盐

CAS 23007-85-4 MFCD00012790

化学结构图

SMILES: Cl.CN1CC=C(CC1)C1C=CC=CC=1

化学属性

Mol. Formula	C12H15N.HCl
Mol. Weight	209.72
Melting Point	249.0 to 254.0 deg-C

别名和识别编码

Chemical Name	1-Methyl-4-Phenyl-1，2，3，6-Tetrahydropyridinehydrochloride
CAS Number	23007-85-4
Synonym	1,2,3,6-Tetrahydro-1-methyl-4-phenylpyridine Hydrochloride 1,2,3,6-Tetrahydro-1-methyl-4-phenylpyridine hydrochloride 1-甲基-4-苯基-1,2,3,6-四氢吡啶盐酸盐 MPTP Hydrochloride MPTP hydrochloride NSC 139654 Hydrochloride
MDL Number	MFCD00012790
PubChem Substance ID	253660522
Beilstein Registry Number	3707312
Reaxys-RN	3707312
Chemical Name Translation	1-甲基-4-苯基-1,2,3,6-四氢吡啶盐酸盐

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产品应用

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride is a dopaminergic neurotoxin that reportedly causes a severe and irreversible Parkinsonian condition in humans and monkeys.

安全信息

RTECSUT8358950

GHS Symbol

Precautionary statements

P301+P310
P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P305+P351+P338
P301+P310+P330
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P501 Dispose of contents/container to..… 处理内容物/容器.....
P405 Store locked up. 上锁保管。
P273 Avoid release to the environment. 避免释放到环境中。
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P301+P312
P330 Rinse mouth. 漱口

Hazard statements

H301 Toxic if swallowed 吞食有毒
H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H301+H311+H331
H335 May cause respiratory irritation 可能导致呼吸道刺激

Hazard Codes

WGK Germany3

Signal word Danger

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S39 Wear eye/face protection 戴眼睛/面孔保护装置；

Risk Statements

R25 Toxic if swallowed 吞咽有毒
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性：吸入，皮肤接触和吞食都会产生十分严重的不可逆危险

UN Number 3077

Hazard Class6.1

Storage condition <0°C

Packing GroupIII

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 53800 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 247,531,1988

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 72 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   BEXBAN Bulletin of Experimental Biology and Medicine (English Translation).
   Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
   10013)  V.41-    1956-  Volume(issue)/page/year: 105,470,1988

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 35 mg/kg
SEX/DURATION            : female 12-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - biochemical and metabolic
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - other hydrolases
REFERENCE :
   LIFSAK Life Sciences.  (Pergamon Press Inc., Maxwell House, Fairview Park,
   Elmsford, NY 10523) V.1-8, 1962-69; V.14-    1974- Volume(issue)/page/year:
   48,217,1991

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 25 mg/kg
SEX/DURATION            : female 17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - maternal-fetal exchange
REFERENCE :
   JONRA9 Journal of Neurochemistry.  (Raven Press, 1185 Ave. of the Americas,
   New York, NY 10036) V.1-    1956-  Volume(issue)/page/year: 55,1427,1990

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 40 mg/kg
SEX/DURATION            : female 15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
   (e.g., placenta, umbilical cord)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 67,63,1991