4-(Aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol dihydrochloride 吡哆胺二盐酸盐一水合物

CAS 524-36-7 MFCD00012808

化学结构图

524-36-7
SMILES: Cc1ncc(CO)c(CN)c1O.Cl.Cl

化学属性

Mol. FormulaC8H14Cl2N2O2
Mol. Weight241.12
Melting Point224-226°C
TSCANo
Appearance 白色片状结晶，易吸湿，室温较稳定，见光逐渐变色。Mp226-227℃ (分解)，在287.5nm波长处有最大吸收。溶于乙醇，易溶于水。
Density1.282
Boiling Point460.1°C at 760 mmHg
Flash Point232.1°C

别名和识别编码

Chemical Name4-(Aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol dihydrochloride
MDL NumberMFCD00012808
CAS Number524-36-7
Synonym Pyridoxylamine (dihydrochloride) {LY} Pyridoxylamine (dihydrochloride) {} {LY} Pyridoxylamine (dihydrochloride) {} {} {LY} Pyridoxylamine (dihydrochloride) {} {} {} {LY} Pyridoxylamine (dihydrochloride) {} {} {} {} {LY} Pyridoxylamine (dihydrochloride) {} {} {} {} {} {LY} Pyridoxylamine (dihydrochloride) {} {} {} {} {} {} {LY} Pyridoxylamine (dihydrochloride) {} {} {} {} {} {} {} {LY} Pyridoxylamine (dihydrochloride) {} {} {} {} {} {} {} {} {LY} Pyridoxylamine (dihydrochloride) {} {} {} {} {} {} {} {} {} {LY} Pyridoxylamine (dihydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyridoxylamine (dihydrochloride) {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {LY} Pyridoxylamine (dihydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyridoxylamine (dihydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyridoxylamine (dihydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyridoxylamine (dihydrochl
PubChem Substance ID10664
EC Number208-357-6
Beilstein Registry Number3632748
Merck Number7980
Reaxys-RN3632748
Chemical Name Translation吡哆胺二盐酸盐一水合物
Wiswesser Line NotationT6NJ B1 CQ D1Z E1Q &GH 2
LabNetwork Molecule IDLN00189201
InChIInChI=1S/C8H12N2O2.2ClH/c1-5-8(12)7(2-9)6(4-11)3-10-5;;/h3,11-12H,2,4,9H2,1H3;2*1H
Canonical SMILESOCC1=C(CN)C(O)=C(C)N=C1.[H]Cl.[H]Cl
信息真实价格透明    资金保障    专业采购外包团队在线服务   
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分类

  • {SNA} Nutrition Research, Vitamin B, Vitamin B6, Vitamins
  • {SNA} Amino Acids and Vitamins, Cell Culture, Reagents and Supplements, Vitamins
  • {SNA} Amino Acids and Vitamins, Vitamins, 细胞培养, 试剂和添加剂
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, P, PU - PZ
  • {Chemicalbook} 生物化学品: 生化试剂: 辅酶和维生素

相关文献及参考

  • Merck: 14,7980
  • Merck: 14,7980 Beilstein: 22,IV,6064 / Beil. 22,V,12,324
  • [1]. Stitt A, et al. The AGE inhibitor pyridoxamine inhibits development of retinopathy in experimental diabetes. Diabetes. 2002 Sep;51(9):2826-32.

安全信息

GHS Symbol
WGK Germany2
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
RTECSUV1230000
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Warning
Hazard Codes Xi
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition 2-8°C, sealed storage, away from moisture and light {LY} 2-8°C, sealed storage, away from moisture and light <0°C {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {} {} {} { 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7500 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 11,922,1961

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2950 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 11,922,19

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 700 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 11,922,1961

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Bird - pigeon
DOSE/DURATION           : 795 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1

其他信息

  • MOL 文件:524-36-7.mol
  • 参考质量标准:含量≥98%，检测溶解度、水分、铵盐、重金属及灼烧残渣等杂质含量。
  • 盐酸吡多胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 P0560 吡哆胺二盐酸盐一水合物 Pyridoxamine Dihydrochloride Monohydrate 5G 1690元 2011/04/16 P0560 吡哆胺二盐酸盐一水合物 Pyridoxamine Dihydrochloride Monohydrate 1G 572元
  • Sigma Aldrich:524-36-7(sigmaaldrich)
  • 图谱信息:盐酸吡多胺(524-36-7)红外图谱(IR1)
  • MSDS 信息:Pyridoxamine dihydrochloride(524-36-7).msds
  • 盐酸吡多胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 P0560 吡哆胺二盐酸盐一水合物 Pyridoxamine Dihydrochloride Monohydrate 5G 1720元 2014/06/02 P0560 吡哆胺二盐酸盐一水合物 Pyridoxamine Dihydrochloride Monohydrate 1G 461元
  • 下游产品:磷酸吡哆醛
  • 用途一:生化研究，药理作用同维生素B 6 。
  • 上游原料:二氧化锰 --> 吡哆醇盐酸盐
  • 方法一:盐酸吡哆辛经二氧化锰氧化，与羟胺缩合，再经金属锌还原制得。
  • TCI Shanghai:吡哆胺盐酸盐一水合物 Pyridoxamine Dihydrochloride Monohydrate,>;98.0%(LC)(N)(524-36-7)

系列性分类

  1. Life Science 生命科学
  2. Cell Culture 细胞培养
  3. Reagents and Supplements - Cell Culture
  4. Amino Acids and Vitamins - Reagents and Supplements
  5. Vitamins - Amino Acids and Vitamins
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Forensic and Veterinary Standards - Chromatography
  5. Drugs &amp; Metabolites - Forensic and Veterinary Standards
  6. Neat Compounds - Drugs &amp; Metabolites
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. P - Alphabetic
  5. PU - PZ - P
  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Vitamins - Nutrition Research
  4. Vitamin B - Vitamins
  5. Vitamin B6 - Vitamin B
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Pyridinium Compounds
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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