2-(Chloromethyl)pyridine Hydrochloride 2-氯甲基吡啶盐酸盐
CAS 6959-47-3 MFCD00012811
信息真实价格透明
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信息真实价格透明
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专业采购外包团队在线服务
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分类
- {SNA} Building Blocks, C6, Chemical Synthesis, Heterocyclic Building Blocks, Pyridines
- {SNA} Building Blocks, C6, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks, Pyridines
相关文献及参考
- Beilstein: 20,V,5,498
- For a study of the base-catalyzed alkylation of p-t-butylcalix[5]arene, see: J. Org. Chem., 61, 2407 (1996).
- The free base has also been used for the protection of OH groups as 2-picolyl derivatives, relatively stable to acid (HF, TFA) but selectively cleaved by electrolytic reduction: Acta Chem. Scand. B, B37, 475 (1983); J. Chem. Res. (Synop.), 22 (1977).
- The free base, generated from the hydrochloride with aqueous OH-, can be metallated (LDA, -78o) at the methylene group. Subsequent reaction with a ketone provides a route to otherwise inaccessible pyridyloxiranes: Tetrahedron Lett., 35, 3175 (1994). Similarly, reaction of the lithio derivative with an imine gives a pyridylaziridine, generally in good yield: J. Org. Chem., 60, 2279 (1995).
安全信息
GHS Symbol
- S24 Avoid contact with skin 避免皮肤接触;
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
- R21/22 Harmful in contact with skin and if swallowed 皮肤接触和不慎吞咽有害
- R22 Harmful if swallowed 吞咽有害
- R34 Causes burns 会导致灼伤
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R4 Forms very sensitive explosive metallic compounds 生成非常敏感的易爆炸金属化合物
- R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P330+P331
- P303+P361+P353+P310+P363
- P304+P340
- P304+P340+P310
- P305+P351+P338
- P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
- H302 Harmful if swallowed 吞食有害
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 316 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NCILB* Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to the National Cancer Institute by Litton Bionetics, Inc. (Bethesda, MD) Volume(issue)/page/year: NCI-E-C-72-3252,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 316 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NCILB* Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to the National Cancer Institute by Litton Bionetics, Inc. (Bethesda, MD) Volume(issue)/page/year: NCI-E-C-72-3252,1973
TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 95250 nmol/L REFERENCE : EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 19,98,1992
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 1 mg/plate REFERENCE : NTPTB* NTP Technical Bulletin. (National Toxicology Program, Landow Bldg. 3A-06, 7910 Woodmont Ave., Bethesda, MD 20205) Volume(issue)/page/year: APR1982
TYPE OF TEST : Specific locus test ROUTE OF EXPOSURE : Oral TEST SYSTEM : Insect - Drosophila melanogaster DOSE/DURATION : 2 mmol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 341,161,1995
其他信息
- MSDS 信息:2-(Chloromethyl)pyridine hydrochloride(6959-47-3).msds
- F:3-10
- 2-氯甲基吡啶盐酸盐价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 172120050 2-氯甲基吡啶盐酸盐 2-Picolyl chloride hydrochloride 98% 5 GR 317元 2010/06/21 172120250 2-氯甲基吡啶盐酸盐 2-Picolyl chloride hydrochloride 98% 25 GR 1001元 2010/06/21 172121000 2-氯甲基吡啶盐酸盐 2-Picolyl chloride hydrochloride 98% 100 GR 2685元
- 用途二:2-氯甲基吡啶是植物生长调节剂吡啶醇的中间体,也是医药扑尔敏的中间体。
- Acros Organics:2-(氯甲基)吡啶盐酸盐 2-Picolyl chloride hydrochloride, 98%(6959-47-3)
- MOL 文件:6959-47-3.mol
- 下游产品:二甲基吡啶胺
- 上游原料:碳酸钠 --> 2-甲基吡啶
- 检测方法:T,NMR
- 图谱信息:2-氯甲基吡啶盐酸盐(6959-47-3)红外图谱(IR1) 2-氯甲基吡啶盐酸盐(6959-47-3)红外图谱(IR2) 2-氯甲基吡啶盐酸盐(6959-47-3)质谱(MS) 2-氯甲基吡啶盐酸盐(6959-47-3)核磁图( 13 CNMR)
- TCI Shanghai:2-(氯甲基)吡啶盐酸盐 2-(Chloromethyl)pyridine Hydrochloride,>;98.0%(T)(6959-47-3)
- 水中溶解度:≥10 g/100 mL
- 敏感性:Hygroscopic
- Sigma Aldrich:6959-47-3(sigmaaldrich)
- 用途一:用作医药中间体
- Alfa Aesar:2-氯甲基吡啶盐酸盐,98% 2-(Chloromethyl)pyridine hydrochloride, 98%(6959-47-3)
- Hazard Note:Corrosive
- 方法一:其制备方法是将2-甲基吡啶及四氯化碳混合后,加入无水碳酸钠,加热,当升温至58~60℃时,在光照射下开始通氯气,温度保持在60~65℃,由气相色谱控制反应终点,经脱溶再蒸馏,与盐酸成盐得到产品。