Betahistine Dihydrochloride 倍他司丁二盐酸盐
CAS 5579-84-0 MFCD00012813
化学结构图
SMILES: CNCCc1ccccn1.Cl.Cl
化学属性
| Mol. Formula | C8H14Cl2N2 |
|---|---|
| Mol. Weight | 209.12 |
| Melting Point | 150-154°C |
| Appearance | 白色或类白色结晶或结晶性粉末。 |
| Density | 0.967 |
| Boiling Point | 210.9°C at 760 mmHg |
| Flash Point | 96.7°C |
别名和识别编码
| Chemical Name | Betahistine Dihydrochloride |
|---|---|
| MDL Number | MFCD00012813 |
| CAS Number | 5579-84-0 |
| Synonym | Betahistine (dihydrochloride) {LY} Betahistine (dihydrochloride) Betahistine Biphar Betahistine Dihydrobromide Betahistine Dihydrochloride {} {LY} Betahistine (dihydrochloride) {} {} {LY} Betahistine (dihydrochloride) {} {} {} {LY} Betahistine (dihydrochloride) {} {} {} {} {LY} Betahistine (dihydrochloride) {} {} {} {} {} {LY} Betahistine (dihydrochloride) {} {} {} {} {} {} {LY} Betahistine (dihydrochloride) {} {} {} {} {} {} {} {LY} Betahistine (dihydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Betahistine (dihydrochloride) {} {} {} {} {} {} {} {} {} {LY} Betahistine (dihydrochloride) {} {} {} {} {} {} {} {} {} {} {LY} Betahistine (dihydrochloride) {} {} {} {} {} {} {} {} {} {} {} {LY} Betahistine (dihydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} Betahistine (dihydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Betahistine (dihydrochloride) {} {} {} {} {} |
| EC Number | 226-966-5 |
| PubChem Substance ID | 68643 |
| Alfabeta Name | METHYLPYRIDINYLETHANAMINEHYDROCHLORIDE N22----- |
| Chemical Name Translation | 倍他司丁二盐酸盐 |
| LabNetwork Molecule ID | LN00178673 |
| InChI | InChI=1S/C8H12N2.2ClH/c1-9-7-5-8-4-2-3-6-10-8;;/h2-4,6,9H,5,7H2,1H3;2*1H |
| Canonical SMILES | CNCCC1=CC=CC=N1.Cl.Cl |
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分类
- {SNA} Analytical St
- {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Standards, Pharmacopeia Standards, USP Standards, USP Standards A - B
- {SNA} Analytical Standards, EP Standards, EP Standards A - B, Pharmacopeia & Metrological Institutes Standards, 分析/色谱
- {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, EP Standards, EP Standards A - B, Pharmaceutical Standards, Pharmacopeia Standards
- {SNA} Analytical Standards, Chromatography, EP Standards, EP Standards A - B, Pharmaceutical Standards,
- {SNA} Building Blocks, C8, Chemical Synthesis,
相关文献及参考
- [2]. Gbahou F, et al. Effects of betahistine at histamine H3 receptors: mixed inverse agonism/agonism in vitro and partial inverse agonism in vivo.J Pharmacol Exp Ther. 2010 Sep 1;334(3):945-54.
- [3]. Tang KT, et al. Betahistine attenuates murine collagen-induced arthritis by suppressing both inflammatory and Th17 cell responses.Int Immunopharmacol. 2016 Oct;39:236-245.
- [1]. Poyurovsky M, et al. The effect of betahistine, a histamine H1 receptor agonist/H3 antagonist, on olanzapine-induced weight gain in first-episode schizophrenia patients. Int Clin Psychopharmacol. 2005 Mar;20(2):101-3.
- [1]. Poyurovsky M, et al. The effect of betahistine, a histamine H1 receptor agonist/H3 antagonist, on olanzapine-induced weight gain in first-episode schizophrenia patients. Int Clin Psychopharmacol. 2005 Mar;20(2):101-3.
- [2]. Gbahou F, et al. Effects of betahistine at histamine H3 receptors: mixed inverse agonism/agonism in vitro and partial inverse agonism
安全信息
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P273 Avoid release to the environment. 避免释放到环境中。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P302+P352
- P304+P340
- P305+P351+P338
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
- P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
- P332+P313
- P337+P313
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
- P403+P233
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H413 Maycauselonglastingharmfuleffectstoaquaticlife 可能对水生生物造成长期持续有害影响。
其他信息
- MOL 文件:5579-84-0.mol
- 用途一:用于治疗内耳眩晕症（即美尼尔综合症）、脑动脉硬化、脑供血不足以及高血压引起的眩晕、呕吐与耳鸣。
- 盐酸倍他司汀价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 167990010 盐酸倍他司汀 2-(2-(Methylamino)ethyl)pyridine dihydrochloride 99% 1 GR 278元 2010/06/21 167990250 盐酸倍他司汀 2-(2-(Methylamino)ethyl)pyridine dihydrochloride 99% 25 GR 2984元 2010/06/21 167990050 盐酸倍他司汀 2-(2-(Methylamino)ethyl)pyridine dihydrochloride 99% 5 GR 755元
- 组胺类扩张血管药物:盐酸倍他司汀又称抗眩宁、培他啶，为组胺H1受体激动剂，属组胺类扩张血管药物，具有扩张毛细血管，改善微循环作用，能增加脑血流量及内耳血流量，能松弛内耳毛细血管前括约肌，可消除内耳性眩晕、耳鸣和耳闭塞感。主要用于治疗梅尼埃病(一种特发性内耳疾病)，急、慢性缺血性脑血管疾病，也用于治疗脑动脉硬化、缺血性脑血管病、头部外伤或高血压所致直立性眩晕、头昏、耳鸣、耳聋、内耳眩晕症等，对多种原因的头痛均有缓解作用，对褥疮也有明显疗效。 倍他司汀盐酸盐对毛细血管的扩张作用与组胺相似，但不增加其通透性，能显著增加脑和内耳血流量，消除内淋巴水肿，直接抑制前庭神经核多触突Ⅰ型神经元产生的大量冲动，从而消除梅尼埃综合征的眩晕、耳鸣和耳闭等症状。该药也有轻微的抗凝血、抗血小板聚集、降低血液黏滞度和利尿作用。
- Sigma Aldrich:5579-84-0(sigmaaldrich)
- Acros Organics:N-甲基-2-吡啶乙胺二盐酸盐 2-(2-(Methylamino)ethyl)pyridine dihydrochloride, 99%(5579-84-0)
- MSDS 信息:2-(2-(Methylamino)ethyl)pyridine dihydrochloride(5579-84-0).msds
