CAS 645-31-8 MFCD00012897-3-Hydroxytyramine Hydrobromide 3-羟基酪胺氢溴酸盐 TAO{mole}

3-Hydroxytyramine Hydrobromide 3-羟基酪胺氢溴酸盐

CAS 645-31-8 MFCD00012897

化学结构图

SMILES: Br.NCCc1ccc(O)c(O)c1

化学属性

Mol. Formula	(HO)2C6H3CH2CH2NH2·HBr
Mol. Weight	234.09
Melting Point	218-220 °C (lit.)

别名和识别编码

Chemical Name	3-Hydroxytyramine Hydrobromide
MDL Number	MFCD00012897
CAS Number	645-31-8
Synonym	2-(3,4-二羟基苯基)乙胺氢溴酸盐 DOPAMINE HYDROBROMIDE 4-(2-aminoethyl)pyrocatechol hydrobromide 4-(2-aminoethyl)-1,2-benzenediolhydrobromide 4-(2-aminoethyl)-2-benzenediol 4-(2-aminoethyl)-pyrocatecho 4-(aminoethyl)catechol {hazard_ usafel-47 多巴胺氢溴酸盐 USAF EL-47 3,4-二羟基-Β-苯乙胺 4-(2-aminoethyl)pyrocatechol 多巴胺氢溴酸盐 3-Hydroxytramine Hydrobromide 3,4-二羟基苯乙胺氢溴酸盐 Dopamine hydrobromide 4-(2-Aminoethyl)-1,2-benzenediol hydrobromide 3,4-二羟基苯乙胺氢溴酸盐多巴胺氢溴酸盐 Dopamine=PIH 3-HYDROXYTYRAMINE HYDROBROMIDE 3,4-dihydroxy-phenethylaminhydrobromide 2-benzenediol,4-(2-aminoethyl)-hydrobromide
PubChem Substance ID	71564
EC Number	211-436-8
Chemical Name Translation	3-羟基酪胺氢溴酸盐
Wiswesser Line Notation	Z2R CQ DQ &EH
InChIKey	SGRSNYSOAPBTJP-UHFFFAOYSA-N
InChI	InChI=1S/C8H11NO2.BrH/c9-4-3-6-1-2-7(10)8(11)5-6;/h1-2,5,10-11H,3-4,9H2;1H

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安全信息

WGK Germany3

GHS Symbol

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P302+P352
P304+P340
P305+P351+P338
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P332+P313
P337+P313
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P403+P233
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word Warning

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H335 May cause respiratory irritation 可能导致呼吸道刺激

RTECSSH2290150

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes Xi

Safety Statements

S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S37 Wear suitable gloves 戴适当手套；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD277-689

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 20 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   11,523,1988

其他信息

MOL 文件:645-31-8.mol
上游原料:锌粉 --> 香兰素 --> 硝基甲烷 --> 2-甲氧基-4-(2-氨基乙基)苯酚 --> 盐酸多巴胺 --> 2-苯乙胺盐酸盐
用途二:该品为抗休克药物。
方法一:由3-O-甲基多巴胺盐酸盐（见24653）水解得到。将3-O-甲基多巴胺盐酸盐、48%氢溴酸及盐酸加入反应锅，缓慢升温至产生的气泡消失后再回流2h。静置过夜，析出结晶，冷却，过滤，用盐酸洗涤滤饼，真空干燥，得成品。
MSDS 信息:645-31-8.msds
Sigma Aldrich:645-31-8(sigmaaldrich)
用途一:药物多巴胺的中间体。
方法二:由香兰醛与硝基甲烷缩合得到3-甲氧基-4-羟基-β-硝基苯乙烯，再用锌粉还原为3-甲氧基-4-羟基-β-苯乙胺盐酸盐，然后水解而得多巴胺盐酸盐。另一种方法是由胡椒乙胺开环而得。