CAS 62-31-7 MFCD00012898-3-Hydroxytyramine hydrochloride 盐酸多巴胺 TAO{mole}

3-Hydroxytyramine hydrochloride 盐酸多巴胺

CAS 62-31-7 MFCD00012898

化学结构图

SMILES: Cl.NCCc1ccc(O)c(O)c1

化学属性

Mol. Formula	C8H12ClNO2
Mol. Weight	189.64
Melting Point	248-250
TSCA	Yes
Solubility	Soluble in water (38 mg/mL) at 25 °C, methanol, hot 95% ethanol, DMSO (38 mg/mL) at 25 °C, aqueous solutions of alkali hydroxides, alcohol (20 mg/ml), and ethanol (2 mg/ml). Insoluble in ether, petroleum ether, chloroform, benzene, and toluene.
Density	1.3034
Stability	易吸潮,对热、光线和空气敏感
Appearance	白色针状结晶或结晶性粉末。熔点240-241℃（分解）。易溶于水，溶于甲醇和热95%乙醇，溶于氢氧化钠溶液，不溶于醚、氯仿、苯。无气味，味微苦。

别名和识别编码

Chemical Name	3-Hydroxytyramine hydrochloride
Synonym	3-羟基酷胺盐酸盐 LABOTEST-BB LT00233111 dopaminechloride 2-(3,4-Dihydroxyphenyl)ethylamine hydrochloride 2-benzenediol,4-(2-aminoethyl)-hydrochloride 4-(2-氨基乙基)-1,2-苯二酚盐酸盐 4-(2-AMINOETHYL)-1-2-BENZENEDIAL HYDROCHLORIDE 多巴胺盐酸盐, 99% DOPAMINE HYDROCHLORIDE 羟酪胺盐酸盐儿茶酚乙胺盐酸盐多巴胺,3羟酷胺儿茶酚乙胺 4-(2-氨乙基)-1,2-苯二醇盐酸盐 3-HYDROXYTYRAMINE HYDROCHLORIDE Intropin 多巴胺盐酸盐 3-HYDROXYTYRAMINIUM CHLORIDE 1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride 3-羟基酪胺盐酸盐 m-Hydroxytyramine hydrochl Dopamine hydrochloride 多巴胺盐酸盐盐酸多巴胺盐酸-3
CAS Number	62-31-7
EC Number	200-527-8
Beilstein Registry Number	3656720
MDL Number	MFCD00012898
PubChem Substance ID	65340
Merck Number	8462
Chemical Name Translation	盐酸多巴胺
Wiswesser Line Notation	Z2R CQ DQ &GH
LabNetwork Molecule ID	LN00193473
InChI	InChI=1S/C8H11NO2.ClH/c9-4-3-6-1-2-7(10)8(11)5-6;/h1-2,5,10-11H,3-4,9H2;1H

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分类

{SNA} Agonists, Biochemicals and Reagents, Catecholamine, Cell Signaling and Neuroscience, Cofactor, Dopaminergics, Dopaminergics - Agonists, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Metabolic Pathways, Metabolites and Cofactors on the Metabolic Pathway

产品应用

神经递质（Neurotransmitter）

安全信息

GHS Symbol

WGK Germany3

Hazard statements

H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
H302 Harmful if swallowed 吞食有害

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

RTECSUX1092000

Precautionary statements

Signal word

Safety Statements

S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S37 Wear suitable gloves 戴适当手套；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R22 Harmful if swallowed 吞咽有害
R50/53

Storage condition Light Sensitive & Hygroscopic 储存温度2-8℃ 对光和空气敏感。储存温度2-8℃,充氩保存

Packing GroupIII

UN Number

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 597 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Olfaction) - effect, not otherwise
   specified
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 8,2311,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 914 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Olfaction) - effect, not otherwise
   specified
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 8,2311,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4361 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Olfaction) - effect, not otherwise
   specified
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 8,2311,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4800 ug/kg
T

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 93800 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 124,9,1983

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Rodent - mouse Liver
DOSE/DURATION           : 6 umol/L
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 62,947,1979

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 900 ug/disc
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 137,17,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 7 mg/kg
SEX/DURATION            : female 1-7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specif

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 300 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 28,2208,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 900 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 28,2208,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2100 ug/kg
SEX/DURATION            : female 7-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 8,2311,1974

其他信息

下游产品:2-(3,4-二羟基苯基)乙胺
毒性分级:中毒
3-Hydroxytyramine, Hydrochloride is a major catecholamine neurotransmitter derived from the amino acid tyrosine and serves as the precursor to norepinephrine and epinephrine. Dopamine activates a variety of dopamine receptors and is known to increase heart rate and blo
MSDS 信息:3-Hydroxytyramine hydrochloride(62-31-7).msds
急性毒性:口服- 大鼠 LD50 2859 毫克/ 公斤; 口服- 小鼠 LD50: 4361 毫克/公斤
灭火剂:水, 二氧化碳, 干粉, 砂土
海关编码:29222900
可燃性危险特性:可燃, 燃烧时分解有毒氮氧化物, 氯化物气体
用途一:该品为升压药，也是一种生化试剂。多巴胺受体激动药，可兴奋心脏，增加肾血流量，用于失血性、心乏性及感染性休克。
上游原料:醋酸异丙酯
color:light tan
敏感性:Air & Light Sensitive
Sigma Aldrich:62-31-7(sigmaaldrich)
TCI Shanghai:多巴胺盐酸盐 3-Hydroxytyramine Hydrochloride,>;98.0%(LC)(T)(62-31-7)
{Che
类别:有毒物质
用途二:本品是儿茶酚类药物，能增加心血输出量，有抗低血压作用。
Acros Organics:盐酸多巴胺 3-Hydroxytyramine hydrochloride, 99%(62-31-7)
MOL 文件:62-31-7.mol
F:8-10-23
3-Hydroxytyramine, Hydrochloride is a major catecholamine neurotransmitter derived from the amino acid tyrosine and serves as the precursor to norepinephrine and epinephrine.
储运特性:库房低温, 通风, 干燥
图谱信息:盐酸多巴胺(62-31-7)红外图谱(IR1) 盐酸多巴胺(62-31-7)质谱(MS) 盐酸多巴胺(62-31-7)核磁图( 13 CNMR) 盐酸多巴胺(62-31-7)核磁图( 1 HNMR) 盐酸多巴胺(62-31-7)红外图谱(IR2)
盐酸多巴胺价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 K5661001 3-羟基酪胺盐酸盐;盐酸-3-羟基酪胺;多巴胺盐酸盐;儿茶酚乙胺盐酸盐;3,4-二羟基-β-苯基乙胺盐酸盐 5g 359元 2011/08/23 SH850201 盐酸多巴胺 5g 449元 2011/04/16 A0305 3-羟基酪胺盐酸盐 3-Hydroxytyramine Hydrochloride 5G 450元
方法一:由胡椒乙胺开环而得。将胡椒乙胺和苯酚加入反应锅，冷却，慢慢加入盐酸，升温至110℃回流12-44h。反应到达终点后，稍冷，加水搅拌均匀。静置分层，分去酚层。水层用乙酸异丙酯提取，提取后的水层减压（8.0kPa）蒸发至干，再加入1/2量乙醇和盐酸，加热溶解。冷却，结晶，过滤，滤饼用乙醇洗涤，干燥，得成品。收率74%。
Hazard Note:Irritant
无臭、味微若；露置空氯中及遇光色渐变深。本品在水中易溶，在无水乙醇中微溶，在氯仿或乙醚中极微溶解。