CAS 563-41-7 MFCD00013009-Semicarbazide hydrochloride 盐酸氨基脲 TAO{mole}

Semicarbazide hydrochloride 盐酸氨基脲

CAS 563-41-7 MFCD00013009

化学结构图

SMILES: Cl.NNC(N)=O

化学属性

Mol. Formula	CH6ClN3O
Mol. Weight	111.53
Melting Point	175-177°C
TSCA	Yes
Density	1.286
Solubility	100 G/L (15 ºC)
Stability	对湿度敏感
Appearance	无色透明或白色结晶。溶于水，不溶于无水乙醇和乙醚。
Boiling Point	394.09 °C at 760 mmHg

别名和识别编码

Chemical Name	Semicarbazide hydrochloride
CAS Number	563-41-7
Synonym	Semicarbazide (hydrochloride) {LY} Semicarbazide (hydrochloride) {} {LY} Semicarbazide (hydrochloride) {} {} {LY} Semicarbazide (hydrochloride) {} {} {} {LY} Semicarbazide (hydrochloride) {} {} {} {} {LY} Semicarbazide (hydrochloride) {} {} {} {} {} {LY} Semicarbazide (hydrochloride) {} {} {} {} {} {} {LY} Semicarbazide (hydrochloride) {} {} {} {} {} {} {} {LY} Semicarbazide (hydrochloride) {} {} {} {} {} {} {} {} {LY} Semicarbazide (hydrochloride) {} {} {} {} {} {} {} {} {} {LY} Semicarbazide (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Semicarbazide (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {LY} Semicarbazide (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {LY} Semicarbazide (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Semicarbazide (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Semicarbazide (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {}
Beilstein Registry Number	3,98
PubChem Substance ID	11236
EC Number	209-247-0
MDL Number	MFCD00013009
Reaxys-RN	3593642
Merck Number	8444
Chemical Name Translation	盐酸氨基脲
Wiswesser Line Notation	ZVMZ &GH
LabNetwork Molecule ID	LN00197635
InChI	InChI=1S/CH5N3O.ClH/c2-1(5)4-3;/h3H2,(H3,2,4,5);1H
Canonical SMILES	NNC(N)=O.[H]Cl

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产品应用

测定酮、醛的试剂、色谱分析试剂及分离激素和精油的溶剂。脲酶底物，MAO抑制剂。

安全信息

Precautionary statements

P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P332+P313
P501 Dispose of contents/container to..… 处理内容物/容器.....
P301+P310
P302+P350
P308+P313
P302+P352+P332+P313+P362+P364
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。

RTECSVT3500000

GHS Symbol

Signal word

Hazard statements

H301 Toxic if swallowed 吞食有毒

Hazard Codes T

WGK Germany3

Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

UN Number UN 2811 6.1/PG 3 2811

Safety Statements

S22 Do not breathe dust 不要吸入粉尘；
S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；

Risk Statements

R25 Toxic if swallowed 吞咽有毒
R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
R22 Harmful if swallowed 吞咽有害
R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

Packing GroupIII

Storage condition 2-8°C, sealed storage, away from moisture {LY} 2-8°C, sealed storage, away from moisture {} {LY} 2-8°C, sealed storage, away from moisture {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed sto

Hazard Class6.1

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 67 gm/kg/76W-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Vascular - tumors
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   EJCAAH European Journal of Cancer.  (Oxford, UK)  V.1-17(6), 1965-1981. For
   publisher information, see EJCODS.  Volume(issue)/page/year: 11,17,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 167 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ABMGAJ Acta Biologica et Medica Germanica.  (Berlin, Ger. Dem. Rep.) V.1-41,
   1958-82.  For publisher information, see BBIADT. Volume(issue)/page/year:
   21,635,1968

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 145 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 24,623,1961

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - excitement
   Behavioral - ataxia
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 24,623,1961

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 225 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 10,686,1960

TYPE OF TEST            : Sperm Morphology
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - grasshopper
DOSE/DURATION           : 100 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 40,237,1976

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - grasshopper
DOSE/DURATION           : 100 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 40,237,1976

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - grasshopper
DOSE/DURATION           : 100 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 40,237,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 100 mg/kg
SEX/DURATION            : female 7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   ACATA5 Acta Anatomica.  (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY
   10003)  V.1-    1945-  Volume(issue)/page/year: 100,347,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 550 mg/kg
SEX/DURATION            : female 1-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   BNEOBV Biology of the Neonate.  (S. Karger Pub., Inc., 79 Fifth Ave., New
   York, NY 10003) V.15-    1970-  Volume(issue)/page/year: 49,150,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 74 mg/kg
SEX/DURATION            : female 10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   BNEOBV Biology of the Neonate.  (S. Karger Pub., Inc., 79 Fifth Ave., New
   York, NY 10003) V.15-    1970-  Volume(issue)/page/year: 49,150,1986

其他信息

方法一:以水合肼及尿素为原料，经缩合而得氨基脲液，然后加入盐酸进行酸化络合，经水冷结晶即得成品。在反应过程中生成的氨、用废酸（盐酸、硫酸混合液）中和后可用作肥料。
用途四:用作分析试剂和色层分析试剂
溶于水，不溶于无水乙醇和乙醚。
Sigma Aldrich:563-41-7(sigmaaldrich)
用途一:本品是医药工业原料，用以制取硝基呋喃类等药物，也用作测定酮、醛的试剂，色谱分析及分离激素的精油的溶剂，也是农药中间体
用途五:本品是医药工业的原料，用以制取硝基呋喃类等药物。也用作测定酮、醛的试剂、色谱分析试剂及分离激素和精油的溶剂。
盐酸氨基脲价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 30164017 氨基脲盐酸盐;盐酸氨脲 250g 114元 2011/08/23 30164014 氨基脲盐酸盐;盐酸氨脲 25g 23元 2011/04/16 S0032 盐酸氨基脲 Semicarbazide Hydrochloride 500G 800元
TCI Shanghai:盐酸氨基脲 Semicarbazide Hydrochloride,>;98.5%(T)(563-41-7)
用途二:是医药、农药的中间体，用于制呋喃西林、硝基呋喃妥因等药物
用途三:用作医药原料，用以制取硝基呋喃类药物
下游产品:氨基脲 --> 3-苯基-1H-吡唑-4-甲醛 --> 5-氯-4-氯甲基-1,2,3-噻二唑 --> 3-氨基-5-苯基吡唑 --> 3-(4-氟丙基)-1H-吡唑-4-甲醛 --> 4-苯基-1，2，3-噻重氮-5-羧酸乙酯 --> 4,5-二氯哒嗪-3(2H)-酮 --> 6-氮杂胸腺嘧啶
图谱信息:盐酸氨基脲(563-41-7)红外图谱(IR2) 盐酸氨基脲(563-41-7)质谱(MS) 盐酸氨基脲(563-41-7)红外图谱(IR1) 盐酸氨基脲(563-41-7)核磁图( 13 CNMR) 盐酸氨基脲(563-41-7)Raman光谱
Acros Organics:硝基呋喃代谢产物-呋喃西林SEM(盐酸氨基脲) Semicarbazide hydrochloride, 98%(563-41-7)
Alfa Aesar:氨基脲盐酸盐,99% Semicarbazide hydrochloride, 99%(563-41-7)
MOL 文件:563-41-7.mol
上游原料:水合肼 --> 水合肼 --> 氨基脲