3-Aminopropionitrile 3-氨基丙腈
CAS 151-18-8 MFCD00014820
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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分类
- {SNA} Amines, Building Blocks, C1 to C5, C2 to C5, Chemical Synthesis, Cyanides/Nitriles, Nitrogen Compounds, Organic Building Blocks
- Amines, Building Blocks, C1 to C5, C2 to C5, Chemical Synthesis, Cyanides/Nitriles, New Products for Chemical Synthesis, Nitrogen Compounds, Organic Building Blocks
- {uni_hamburg} no charge; 1fragment
产品应用
- 作有机合成、医药中间体。
相关文献及参考
- Short: II/25C
- Short: II/19b
- Merck:14,469
- Merck:14,469 Beilstein:4(4)2530
安全信息
GHS Symbol
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
- P304+P340
- P301+P312
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P302+P352
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338+P310
- P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
- P303+P361+P353
- P308+P313
- P304+P340+P310
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P301+P330+P331+P310
- H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
- H302 Harmful if swallowed 吞食有害
- H361d Suspected of damaging the unborn child 怀疑对未出生婴儿造成伤害
- H227 Combustible liquid 可燃液体
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S20 When using do not eat or drink 使用时,不得进食,饮水;
- S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
- S27 Take off immediately all contaminated clothing 立即脱掉全部污染的衣服;
- S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
- R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
- R22 Harmful if swallowed 吞咽有害
- R34 Causes burns 会导致灼伤
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1152 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : EXMPA6 Experimental and Molecular Pathology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1962- Volume(issue)/page/year: 39,154,1983
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 12800 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - cyanosis REFERENCE : EXMPA6 Experimental and Molecular Pathology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1962- Volume(issue)/page/year: 39,154,1983
TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Rodent - mouse Embryo DOSE/DURATION : 1250 mg/kg REFERENCE : ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 47,305,1981
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 5 gm/kg SEX/DURATION : female 14-15 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 4,227,1971
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - hamster DOSE : 1250 mg/kg SEX/DURATION : female 11 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 26,59,1982
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE : 1250 mg/kg SEX/DURATION : female 10 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material) REFERENCE : ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 47,305,1981
其他信息
- MSDS 信息:3-氨基丙腈(151-18-8).msds
- 毒性分级:中毒
- 灭火剂:干粉、泡沫、砂土, 二氧化碳, 雾状水
- 用途二:作有机合成、医药中间体。
- TCI Shanghai:3-氨基丙腈(含稳定剂碳酸钾) 3-Aminopropionitrile (stabilized with K2CO3),>;98.0%(GC)(T)(151-18-8)
- 类别:易燃液体
- 爆炸物危险特性:易氧化且不稳定; 储藏时它可聚合为可爆的黄色固体
- Sigma Aldrich:151-18-8(sigmaaldrich)
- 急性毒性:腹腔-小鼠LD50: 1152 毫克/公斤
- 外观性质:具有氨样气味的液体。
- 储运特性:库房通风低温干燥
- 可燃性危险特性:易燃;遇热产生有毒氮氧化物和氰化物烟雾
- 方法一:由丙烯腈经胺化而得。将干燥的高压釜冷至35℃以下,依次加入丙烯腈、二苯胺、叔丁醇,搅拌5min,加入液氨,温度控制在100-109℃,压力在1MPa左右,保温搅拌4h。冷至10℃以下,压力降至常压时停止搅拌。于65-70℃(14.7-21.3kPa)减压回收叔丁醇,得粗品3-氨基丙腈,粗品再减压蒸馏,收集66-105℃(1.33-4.0kPa)馏分,得3-氨基丙腈。
- 下游产品:beta-氨基丙酸 --> 盐酸阿夫唑嗪 --> 1,2-二甲基-1,4,5,6-四氢嘧啶
- Alfa Aesar:3-氨基丙腈,98%,stab.withpotassiumcarbonate 3-Aminopropionitrile, 98%, stab. with potassium carbonate(151-18-8)
- MOL 文件:151-18-8.mol
- Acros Organics:3-氨基丙腈 3-Aminopropionitrile, stabilized, 98%(151-18-8)
- 3-氨基丙腈价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 A0408 3-氨基丙腈(含稳定剂碳酸钾) 3-Aminopropionitrile (stabilized with K2CO3) 25ML 663元 2010/06/21 351750010 3-氨基丙腈 3-Aminopropionitrile 98%, stabilized 1 GR 426元 2010/06/21 351750050 3-氨基丙腈 3-Aminopropionitrile 98%, stabilized 5 GR 1212元
- 3-氨基丙腈价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 A0408 3-氨基丙腈(含稳定剂碳酸钾) 3-Aminopropionitrile (stabilized with K2CO3) 25ML 803元 2010/06/21 351750010 3-氨基丙腈 3-Aminopropionitrile 98%, stabilized 1 GR 426元 2010/06/21 351750050 3-氨基丙腈 3-Aminopropionitrile 98%, stabilized 5 GR 1212元
- 上游原料:氢氧化铵 --> 氨 --> 叔丁醇 --> 丙烯腈 --> 二苯胺
- 图谱信息:3-氨基丙腈(151-18-8)红外图谱(IR1) 3-氨基丙腈(151-18-8)核磁图( 1 HNMR) 3-氨基丙腈(151-18-8)质谱(MS) 3-氨基丙腈(151-18-8)红外图谱(IR3) 3-氨基丙腈(151-18-8)核磁图( 13 CNMR) 3-氨基丙腈(151-18-8)红外图谱(IR2)
- 用途一:用作有机合成、医药中间体。