Isorhamnetin 异鼠李素
CAS 480-19-3 MFCD00017310
化学结构图
SMILES: COC1C=C(C=CC=1O)C1OC2C=C(O)C=C(O)C=2C(=O)C=1O
化学属性
| Mol. Formula | C16H12O7 |
|---|---|
| Mol. Weight | 316.26 |
| Melting Point | 307°C |
| Density | 1.634 |
| Boiling Point | 599.4°C at 760 mmHg |
| Flash Point | 227.8°C |
别名和识别编码
| Chemical Name | Isorhamnetin |
|---|---|
| MDL Number | MFCD00017310 |
| CAS Number | 480-19-3 |
| Synonym | 3'-Methoxyquercetin 3'-O-Methylquercetin 3,4’,5,7-tetrahydroxy-3’-methoxy-flavon 3,5,7-TRIHYDROXY-2-(4-HYDROXY-3-METHOXYPHENYL)-4-BENZOPYRONE 3,5,7-Trihydroxy-2-(4-hydroxy-3-metoxyphenyl)benzopyran-4-on; 3,5,7-Trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-1-benzopyran-4-one 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxy-phenyl)chromen-4-one 3-METHYLQUERCETIN 3’-methoxyquercetin 3′-Methoxy-3,4′,5,7-tetrahydroxyflavone 4H-1-Benzopyran-4-one, 2-(3-methoxy-4-hydroxyphenyl)-3,5,7-trihydroxy- 4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)- C.I. 75680 ISOHAMNETIN ISOHAMNETIN:3'-METHOXY-3,4',5,7-TETRAHYDRO-XY-FLAVONE ISORHAMNETIN Isorhamnetin {} {} {hazard_com} Quercetin 3'-methyl ether {} {} {} {Chemicalbook} QUERCETIN-3-METHYLETHER {} { |
| PubChem Substance ID | 57647674 |
| Beilstein Registry Number | 44723 |
| EC Number | 207-545-5 |
| Chemical Name Translation | 异鼠李素 |
| Wiswesser Line Notation | T66 BO EVJ CR DQ CO1 |
| LabNetwork Molecule ID | LN01308863 |
| Reaxys-RN | 44723 |
| Canonical SMILES | O=C1C(O)=C(C2=CC=C(O)C(OC)=C2)OC3=CC(O)=CC(O)=C13 |
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分类
- {SNA} Alphabetical, Analytical Standards, Analytical/Chromatography, Calendula, Cassia, Chemical Class, Chromatography, Cichorium, Flavonoids, Flavonoids (Catechins), Foeniculum, Ginkgo, Ginkgo biloba, Glycyrrhiza, I - M, Life Sciences Standards, Natural Compounds, Phytochemicals by Plant (Food/Spice/Herb), Phytopharma Standards, Primula, Rhamnus, Standards by Plant Genus, Substance Classification, Tanacetum, Trifolium, Viscum,
- {SNA} Acacia,
- {SNA} Acacia,
相关文献及参考
- [2]. Hu S, et al. Isorhamnetin inhibits cell proliferation and induces apoptosis in breast cancer via Akt and mitogen activated protein kinase kinase signaling pathways. Mol Med Rep. 2015 Nov;12(5):6745-51.
- [1]. Kim JE, et al. Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3-K. Cancer Prev Res (Phila). 2011 Apr;4(4):582-91.
- [1]. Kim JE, et al. Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3-K. Cancer Prev Res (Phila). 2011 Apr;4(4):582-91.
- [2]. Hu S, et al. Isorhamnetin inhibits cell proliferation and induces apoptosis in breast cancer via Akt and mitogen activated protein kinase kinase signaling pathways. Mol Med Rep. 2015 Nov;12(5):6745-51.
安全信息
GHS Symbol
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- H351 Suspected of causing cancer 怀疑致癌
- S22 Do not breathe dust 不要吸入粉尘；
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 11100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,63,1982
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 1 mg/plate REFERENCE : JOPHDQ Journal of Pharmacobio-Dynamics. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1978- Volume(issue)/page/year: 3,236,1980
其他信息
- Sigma Aldrich:480-19-3(sigmaaldrich)
- MOL 文件:480-19-3.mol
