Proxyphylline 7-(2-羟丙基)茶碱
CAS 603-00-9 MFCD00022833
化学结构图
SMILES: CC(O)Cn1cnc2c1c(=O)n(C)c(=O)n2C
化学属性
| Mol. Formula | C10H14N4O3 |
|---|---|
| Mol. Weight | 238.25 |
| Melting Point | 134.0 to 138.0 deg-C |
别名和识别编码
| Chemical Name | Proxyphylline |
|---|---|
| CAS Number | 603-00-9 |
| Synonym | ######## (1,3-Dimethyl-7-[2-hydroxypropyl]-2,6-dioxopurine) 7-(β-Hydroxypropyl)theophylline Proxyphylline (1,3-Dimethyl-7-[2-hydroxypropyl]-2,6-dioxopurine) Proxyphylline 1,3-Dimethyl-7-(2-hydroxypropyl)xanthine 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-7-(2-hydroxypropyl)- 1H-Purine-2,6-dione, 3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethyl- 2-Hydroxypropyl-7-theophylline 3,7-Dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purine-2,6-dione 3,7-dihydro-1,3-dimethyl-7-(2-hydroxypropyl)-1h-purine-6-dione 3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-1h-purine-6-dione 7-(2-Hydroxypropyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione 7-(2-Hydroxypropyl)theophylline 7-(2-hydroxypropyl)-theophyllin 7-(2-hydroxypropyl)theophylline 7-(BETA-HYDROXYPROPYL)THEOPHYLLINE 7-(b |
| MDL Number | MFCD00022833 |
| EC Number | 210-028-7 |
| Chemical Name Translation | 7-(2-羟丙基)茶碱 |
| Reaxys-RN | 262773 |
| Merck Number | 7905 |
| Wiswesser Line Notation | T56 BN DN FNVNVJ B1YQ1 F1 H1 |
| LabNetwork Molecule ID | LN00240959 |
| PubChem Substance ID | 253660319 |
| InChI | InChI=1S/C10H14N4O3/c1-6(15)4-14-5-11-8-7(14)9(16)13(3)10(17)12(8)2/h5-6,15H,4H2,1-3H3 |
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分类
- Heterocycles
- {SNA} Analytical Standards, Chromatography, EP Standards, EP Standards P - R, Pharmaceutical Standards, Pharmacopeia Standards, 分析/色谱
- Pharmaceuticals
- Intermediates & Fine Chemicals
- {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, EP Standards, EP Standards P - R, Pharmaceutical Standards, Pharmacopeia Standards
- Metabolites & Impurities
产品应用
- A metabolite of Theophylline
相关文献及参考
- [2]. Kukovetz WR, et al. Overadditive synergism between theophylline, diprophylline and proxyphylline in tracheal smooth muscle relaxation. Arzneimittelforschung. 1983;33(10):1450-4.
- [3]. Rasmussen FV, et al. Pharmacokinetics and bronchodilatory effect of proxyphylline and theophylline. Eur J Respir Dis. 1984 Jan;65(1):20-7.
- [4]. Selvig K, et al. Inhibition of human lung cyclic nucleotide phosphodiesterases by proxyphylline, theophylline and their metabolites. Acta Pharmacol Toxicol (Copenh). 1982 Sep;51(3):250-2.
- Young, R., et al.: J. Med. Chem., 28, 201 (1993)
- [1]. Takeda K, et al. Effects of aminophylline, proxyphylline and a proxyphylline-Melilotus extract-rutin mixture(theoesberiven) on the heart and the coronary circulat
- [1]. Takeda K, et al. Effects of aminophylline, proxyphylline and a proxyphylline-Melilotus extract-rutin mixture(theoesberiven) on the heart and the coronary circulation. Jpn J Pharmacol. 1977 Oct;27(5):709-20.
安全信息
GHS Symbol
- H302 Harmful if swallowed 吞食有害
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R22 Harmful if swallowed 吞咽有害
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P301+P312
- P301+P312+P330
- P330 Rinse mouth. 漱口
- P501 Dispose of contents/container to..… 处理内容物/容器.....
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 505 mg/kg TOXIC EFFECTS : Details of toxic effects not reported o
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 739 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,1178,1995
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 475 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,1178,1995
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 460 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 19,845,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 445 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,720,1982
TYPE OF TEST : LD50 -
其他信息
- MOL 文件:603-00-9.mol
- 用途一:用于治疗支气管哮喘、喘息性支气管炎等病症
- Sigma Aldrich:603-00-9(sigmaaldrich)
