CAS 130-80-3 MFCD00027002-Diethylstilbestrol Dipropionate 己烯雌酚二丙酸酯 TAO{mole}

Diethylstilbestrol Dipropionate 己烯雌酚二丙酸酯

CAS 130-80-3 MFCD00027002

化学结构图

SMILES: CCC(=O)Oc1ccc(/C(CC)=C(\CC)c2ccc(OC(=O)CC)cc2)cc1

化学属性

Mol. Formula	C24H28O4
Mol. Weight	380.48

别名和识别编码

Chemical Name	Diethylstilbestrol Dipropionate
Synonym	(E)-3,4-二苯基-3-亚己基-p,p'-二丙酸酯 4,4'-Stilbe 4,4'-Stilbenediol, a,a' 4,4'-Dihydroxy-alpha,beta-diethylstilbene dipropionate 4,4'-Stilbenediol, alpha,alpha'-diethyl-, dipropionate, trans- pp,p'-Dipropionoxy-trans-a,ß-diethylstilbene Cline Cyren B Dibestil Die Diethylstilbene dipropionate Diethylstilbestrol Dipropionate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
MDL Number	MFCD00027002
PubChem Substance ID	657220
CAS Number	130-80-3
EC Number	204-995-4
Chemical Name Translation	己烯雌酚二丙酸酯
Wiswesser Line Notation	2VOR DY2&UY2&R DOV2
Beilstein Registry Number	2632126
LabNetwork Molecule ID	LN00193593
InChI	InChI=1S/C24H28O4/c1-5-21(17-9-13-19(14-10-17)27-23(25)7-3)22(6-2)18-11-15-20(16-12-18)28-24(26)8-4/h9-16H,5-8H2,1-4H3/b22-21+
Canonical SMILES	CCC(=O)Oc1ccc(cc1)\C(=C(/CC)\c2ccc(OC(=O)CC)cc2)\CC

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安全信息

RTECSWJ5775000

GHS Symbol

Precautionary statements

P308+P313
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P201 Obtain special instructions before use. 使用前获取专门指示。

Signal word Danger

Hazard statements

H332 Harmful if inhaled 吸入有害
H350 May cause cancer 可能致癌
H302 Harmful if swallowed 吞食有害
H312 Harmful in contact with skin 皮肤接触有害
H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害

Hazard Codes T

WGK Germany3

Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S22 Do not breathe dust 不要吸入粉尘；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；

Risk Statements

R46 May cause inheritable genetic damage 可能引起遗传基因损害
R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
R45 May cause cancer 可能致癌
R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 133 mg/kg/32W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Liver - tumors
   Kidney, Ureter, Bladder - tumors
REFERENCE :
   BEXBAN Bulletin of Experimental Biology and Medicine (English Translation).
   Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
   10013)  V.41-    1956-  Volume(issue)/page/year: 81,898,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 80 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Endocrine - tumors
   Endocrine - changes in growth hormone
REFERENCE :
   HMMRA2 Hormone and Metabolic Research.  (Georg Thieme Verlag, Postfach 732,
   D-7000 Stuttgart 1, Fed. Rep. Ger.)  V.1-    1969- Volume(issue)/page/year:
   7,228,1975

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 113 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Endocrine - tumors
REFERENCE :
   EJCAAH European Journal of Cancer.  (Oxford, UK)  V.1-17(6), 1965-1981. For
   publisher information, see EJCODS.  Volume(issue)/page/year: 5,99,1969

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 5 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Reproductive - Tumorigenic effects - other reproductive system tumors
REFERENCE :
   RSABAC Revista de la Sociedad Argentina de Biologia.  (Sociedad Argentina de
   Biologia, Instit

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 144,27,1985

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 7500 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 343,7,1995

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 100 mg/L
REFERENCE :
   EVHPAZ EHP, Environmental Health Perspectives.  (U.S. Government Printing
   Office, Supt of Documents, Washington, DC 20402)  No.1-    1972-
   Volume(issue)/page/year: 31,97,1979

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Fibroblast
DOSE/DURATION           : 5 mg/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 3,499,1982

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 1300 nmol/L
REFERENCE :
   TGANAK Tsitologiya i Genetika.  Cytology and Genetics.  For English
   translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-    1967-  Volume(issue)/page/year: 16(2),24,1982

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 1300 nmol/L
REFERENCE :
   TGANAK Tsitologiya i Genetika.  Cytology and Genetics.  Fo

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 20 ug/kg
SEX/DURATION            : female 3-4 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   APTSAI Acta Pharmacologica et Toxicologica, Supplementun.  (Munksgaard
   International Pub., POB 2148, DK-1016 Copenhagen K, Denmark)  No.1- 1947- 
   Volume(issue)/page/year: 26(1),1,1968

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 70 ug/kg
SEX/DURATION            : female 28 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   APTSAI Acta Pharmacologica et Toxicologica, Supplementun.  (Munksgaard
   International Pub., POB 2148, DK-1016 Copenhagen K, Denmark)  No.1- 1947- 
   Volume(issue)/page/year: 26(1),1,1968

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 60 ug/kg
SEX/DURATION            : female 3-4 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   APTSAI Acta Pharmac

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 200 ug/kg
SEX/DURATION            : female 13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
   Filiales.  (SPPIF, B.P.22, F-41353 Vineuil, France)  V.1-

Storage condition -20°C -20℃

Diethylstilbestrol Dipropionate 己烯雌酚二丙酸酯

CAS 130-80-3 MFCD00027002

化学结构图

化学属性

别名和识别编码

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