Carbimazole 卡比马唑

CAS 22232-54-8 MFCD00027421

化学结构图

22232-54-8
SMILES: CN1C=CN(C1=S)C(=O)OCC

化学属性

Mol. FormulaC7H10N2O2S
Mol. Weight186
Melting Point122.0 to 125.0 deg-C
TSCANo
Appearance 白色或类白色结晶性粉末。熔点122-125℃。在20℃时，卡比吗唑(22232-54-8)可溶于500份水；50份乙醇；330份醚；3份氯仿；17份丙酮。有特臭，味苦。

别名和识别编码

Chemical NameCarbimazole
CAS Number22232-54-8
Synonym ######## 1-ETHOXYCARBONYL-3-METHYL-2-THIOXO-4-IMIDAZOLINE 1H-Imidazole-1-carboxylic acid, 2,3-dihydro-3-methyl-2-thioxo, ethyl 1H-Imidazole-1-carboxylic acid, 2,3-dihydro-3-methyl-2-thioxo-, ethyl ester 1h-imidazole-1-carboxylicacid,2,3-dihydro-3-methyl-2-thioxo,ethylester 2,3-Dihydro-3-methyl-2-thioxo-1H-imidazole-1-carboxylicacidethylester 2-Carbethoxythio-1-methylimidazole 2-仲丁基苯基-N-甲基氨基甲酸酯 3-Methyl-2-thioxo-4-imidazoline-1-carboxylic acid ethyl ester 3-methyl-2-thioxo-4-imidazoline-1-carboxylicacidethylester 3-methyl-2-thioxo-4-imidazoline-1-carboxylicaciethylester 3-甲基-2-硫代咪唑啉-1-甲酯乙基 3-甲基-2-硫代咪唑啉-1-羧酸乙酯 4-Imidazoline-1-carboxylic acid, 3-methyl-2-thioxo-, ethyl ester Athyromazole Basolest CARBIMAZOLE CG1 Carbethoxymethimazole Carbimazol Carbimazole Carbinazole ETHYL 3-METHYL-2-THIOMIDAZOLINE-1-CARBOXYLATE ETHYL 3-METHYL-2-THIONOIMIDAZOLINE-1-CARBOXYLATE Ethyl 3-methyl-2-thioimidazoline-1-carboxylate Ethyl 3-methyl-2-thionoimidazoline-1-carboxylate; Ethyl 3-methyl-2-thioxo-2,3-dihydro-1H-imidazole-1-carboxylate Ethyl 3-methyl-2-thioxo-2,3-dihydro-1H-imidazole-1-carboxylate LABOTEST-BB LT00455569 卡比马唑 咔比马唑 新麦咔唑 甲亢平
MDL NumberMFCD00027421
EC Number244-854-4
Merck Number1798
Beilstein Registry Number0144339
Reaxys-RN144339
PubChem Substance ID87566113
Chemical Name Translation卡比马唑
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分类

  • Pharmaceuticals
  • Sulfur & Selenium Compounds
  • Heterocycles
  • Intermediates & Fine Chemicals
  • {SNA} Building Blocks, C3 to C8, Chemical Synthesis, Heterocyclic Building Blocks, Imidazoles

产品应用

  • Carbimazole, a prodrug of Methimazole (M260300), is used in the treatment of hyperthyroidism.

相关文献及参考

  • Marchant, B., et al.: J. Clin. Endocrinol. Metab., 45, 1187 (1977),

安全信息

RTECSNJ2441000
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S24 Avoid contact with skin 避免皮肤接触；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S37 Wear suitable gloves 戴适当手套；
Risk Statements
  • R36 Irritating to eyes 刺激眼睛
  • R22 Harmful if swallowed 吞咽有害
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
Storage condition Light Sensitive
UN Number 3335 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 1 mg/kg/1D-I
TOXIC EFFECTS :
   Liver - jaundice, other or unclassified
REFERENCE :
   NEJMAG New England Journal of Medicine.  (Massachusetts Medical Soc., 10
   Shattuck St., Boston, MA 02115)  V.198-    1928-  Volume(issue)/page/year:
   309,438,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 703 mg/kg/17W-I
TOXIC EFFECTS :
   Sense Organs and Special Senses (Ear) - change in acuity
   Sense Organs and Special Senses (Ear) - tinnitus
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   309,929,1994

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 23 mg/kg/5W-I
TOXIC EFFECTS :
   Liver - jaundice, cholestatic
REFERENCE :
   JRSMD9 Journal of the Royal Society of Medicine.  (Oxford Univ. Press,
   Walton St., Oxford OX2 6DP, UK)  V.71-    1978-  Volume(issue)/page/year:
   78,75,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 25 mg/kg/6W-I
TOXIC EFFECTS :
   Liver - hepatitis (hepatocellular necrosis), diffuse
REFERENCE :
   AIMDAP Archives of Internal Medicine.  (AMA, 535 N. Dearborn St., Chicago,
   IL 60610)  V.1-    1908-  Volume(issue)/page/year: 145,1513,1985

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 1 gm/L
REFERENCE :
   CHINAG Chemistry and Industry (London).  (Royal Soc. of Chemistry,
   Distribution Centre, Blackhorse Rd., Letchworth, Herts SG6 1HN, UK)  V.1-
   1923-  Volume(issue)/page/year: (21),847,1980

WGK Germany3

其他信息

  • Alfa Aesar:3-甲基-2-硫代咪唑啉-1-甲酯乙基,97% Ethyl 3-methyl-2-thionoimidazoline-1-carboxylate, 97%(22232-54-8)
  • 方法一:由氯代乙醛缩二乙醇经胺化、环合、缩合而得。1.胺化将氯代乙醛缩二乙醇、甲胺、甲醇加入耐压锅中反应得2-甲氨基乙醛缩二乙醇。2.环合将2-甲氨基乙醛缩二乙醇与盐酸、硫氰酸钾一起加热，得1-甲基-2-巯基咪唑。3.缩合将1-甲基-2-巯基咪唑缩于吡啶中，滴加氯甲酸乙酯，得卡比马唑。
  • 用途二:为抗甲状腺药，与他巴唑同属巯基咪唑类。卡比马唑是他巴唑的前体药体，在体内转化为他巴唑，其作用和不良反应都与他巴唑相似，作用较缓慢，维持时间比他巴唑长。用于甲状腺亢进。
  • 用途一:对稻飞虱和黑尾叶蝉及稻蝽象触杀有速效
  • TCI Shanghai:甲亢平 Carbimazole,>;99.0%(GC)(22232-54-8)
  • 卡比吗唑价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 C1080 甲亢平 Carbimazole 5G 664元 2011/04/16 C1080 甲亢平 Carbimazole 25G 2010元 2010/05/25 L08218 3-甲基-2-硫代咪唑啉 -1-甲酯乙基, 97% Ethyl 3-methyl-2-thionoimidazoline-1-carboxylate, 97% 25g 2058元
  • 图谱信息:卡比吗唑(22232-54-8)红外图谱(IR2) 卡比吗唑(22232-54-8)质谱(MS) 卡比吗唑(22232-54-8)红外图谱(IR1) 卡比吗唑(22232-54-8)核磁图( 13 CNMR) 卡比吗唑(22232-54-8)核磁图( 1 HNMR)
  • 上游原料:一甲胺 --> 氯甲酸乙酯 --> 硫氰酸钾 --> 氯乙醛缩二乙醇 --> 2-巯基咪唑
  • MOL 文件:22232-54-8.mol
  • 敏感性:Light Sensitive

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Imidazoles 咪唑
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Imidazoles 咪唑
  5. C3 to C8 - Imidazoles

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