CAS 51-42-3 MFCD00035077-(-)-Epinephrine (+)-bitartrate salt 酒石酸肾上腺素 TAO{mole}

(-)-Epinephrine (+)-bitartrate salt 酒石酸肾上腺素

CAS 51-42-3 MFCD00035077

化学结构图

SMILES: CNCC(O)c1ccc(O)c(O)c1.O=C(O)C(O)C(O)C(=O)O

化学属性

Mol. Formula	C9H13NO3· C4H6O6
Mol. Weight	333.29
Melting Point	~155 °C (dec.)
Solubility	DMSO 67 mg/mL Water 67 mg/mL Ethanol <1 mg/mL
Appearance	solid
Refractive index	-16.5 ° (C=2, H2O)

别名和识别编码

Chemical Name	(-)-Epinephrine (+)-bitartrate salt
Synonym	L-1-(3,4-DIHYDROXYPHENYL)-2-METHYLAMINOETHANOL BITARTRATE Adrenaline bitartrate L-Adrenaline (+)-bitartrate salt, L-3,4-Dihydroxy-alpha-(methylaminomethyl)benzyl alcohol D-hydrogen bitartrate salt (-)-Adrenaline bitartrate (-)-EPINEPHRINE (+)BITARTRATE SALT 酒石酸肾上腺素 (-)-EPINEPHRINE-(+)-HYDROGEN TARTRATE L-(-)-EPINEPHRI 酒石酸肾上腺素副肾素 (+)-酒石酸氢盐 L-3,4-Dihydroxy-α-(methylaminomethyl)benzyl alcohol D-hydrogen 酒石酸氢盐 L-Adrenaline D-hydrogentartrate 酒石酸肾上腺素 (-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol (+)-tartrate EPINEPHRINE BITARTRATE L-3,4-二羟基-alpha-((甲氨基)甲基)苄醇 D-酒石酸氢盐 (-)-肾上腺素 (+)-酒石酸氢 L-3,4-DIHYDROXY-ALPHA-[(METHYLAMINO)METHYL]BENZYL ALCOHOL BITARTRATE 1-(3,4-DIHYDROXYPHENYL)-2-(METHYLAMINO)ETHANOL-(+)-BITARTRATE Adrenaline tartrate Adrenalin bitartrate L-3,4-DIHYDROXY-ALPHA-(METHYLAMINOMETHYL)BENZYL ALCOHOL D-HYDROGEN BITARTRATE SALT ADRENALINE BITARTRATE 酒石酸肾上腺素副肾素 (+)-酒石酸氢盐 L-3,4-Dihydroxy-α-(methylaminomethyl)benzyl alcohol D-hydrogen 酒石酸氢盐 L-Adrenaline D-hydrogentartrate l-Adrenaline d-bitartrate L-ADRENALINE BITARTRATE 酒石酸肾上腺素素 {Chemicalbook l-Adrenaline hydrogen tartrate ADRENAL, RAT L-ADRENALINE (+)-BITARTRATE SALT ADRENALINE HYDROGEN TARTRATE 酒石酸肾上腺素副肾素 (+)-酒石酸氢盐 L-3,4-Dihydroxy-α-(methylaminomethyl)benzyl alcohol D-hydrogen 酒石酸氢盐 L-Adrenaline D-hydrogentartrate 酒石酸肾上腺素 ADRENALINE ACID TARTRATE L-ADRENALINE D-HYDROGENTARTRATE l-Adrenaline bitartrate L-Adrenaline tartrate {Chemicalbo (-)-肾上腺素 (+)-酒石酸氢盐
MDL Number	MFCD00035077
CAS Number	51-42-3
PubChem Substance ID	5815
EC Number	200-097-1
Chemical Name Translation	酒石酸肾上腺素
Merck Number	13,3650
Wiswesser Line Notation	QR BQ DYQ1M1 &QVYQYQVQ -L -D
LabNetwork Molecule ID	LN00239162
InChI	InChI=1S/C9H13NO3.C4H6O6/c1-10-5-9(13)6-2-3-7(11)8(12)4-6;5-1(3(7)8)2(6)4(9)10/h2-4,9-13H,5H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t9-;1-,2-/m01/s1

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分类

{SNA} Analytical Standards, Analytical/Chromatography, Chromatography, EP Standards, EP Standards A - B, Pharmaceutical Standards,
{SNA} Adrenergics, Adrenergics - Agonists, Agonists, Bioactive Small Molecule Alphabetical Index, Biochemicals and Reagents, E, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, Proteins and Derivatives, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
{SNA} Analytical Standards, Analytical/Chromatography, Chromatography, EP Standards,
{SNA}

产品应用

An α,β-adrenergic receptor agonist.

安全信息

RTECSDO3500000

GHS Symbol

Precautionary statements

P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P301+P310
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H335 May cause respiratory irritation 可能导致呼吸道刺激
H319 Causes serious eye irritation 严重刺激眼睛
H300 Fatal if swallowed 吞食致命

WGK Germany3

Signal word Danger

Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；

Hazard Codes T+

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R28 Very toxic if swallowed 吞咽极毒

Packing GroupI

Hazard Class6.1(b)

Storage condition 储存温度-20°C 储存温度 2-8°C 2-8°C

UN Number UN 2811 6.1/PG 1

{hazard_

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURAT

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1780 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 81,269,1944

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 7800 ug/kg
TOXIC EFFECTS :
   Cardiac - cardiomyopathy including infarction
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   31,43,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 8300 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,122,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   31,49,1972

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION           : 1 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   43,3514,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 2400 ug/kg
SEX/DURATION            : male 2 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 22,375,1970

其他信息

毒性分级:剧毒
Epinephrine Bitartrate 是一种α和β-肾上腺素能受体激动剂。
Sigma Aldrich:51-42-3(sigmaaldrich)
(-)-肾上腺素 (+)-酒石酸氢盐
MOL 文件:51-42-3.mol
color:white
储运特性:库房通风低温干燥; 与食品原料分开存放
用途一:主要用于过敏性休克、支气管哮喘及心搏骤停的抢救
灭火剂:干粉、泡沫、砂土、二氧化碳, 雾状水
急性毒性:口服-小鼠 LD50: 4 毫克/公斤；腹腔-小鼠 LD50：0.78 毫克/公斤
TCI Shanghai:酒石酸-L-肾上腺素 L-Adrenaline Bitartrate,>;98.0%(LC)(T)(51-42-3)
可燃性危险特性:可燃; 燃烧释放有毒氮氧化物烟雾
F:8-10-23
图谱信息:酒石酸肾上腺素(51-42-3)红外图谱(IR1) 酒石酸肾上腺素(51-42-3)质谱(MS) 酒石酸肾上腺素(51-42-3)核磁图( 1 HNMR) 酒石酸肾上腺素(51-42-3)红外图谱(IR2)
类别:有毒物品