Nystatin 制霉菌素
CAS 1400-61-9 MFCD00036240
化学结构图
SMILES: CC1C=CC=CCCC=CC=CC=CC=CC(OC2OC(C)C(O)C(N)C2O)CC(O)C(C(=O)O)C(O)CC(=O)CC(O)C(O)CCC(O)CC(O)CC(O)CC(=O)OC(C)C(C)C1O
化学属性
| Mol. Formula | C47H75NO17 |
|---|---|
| Mol. Weight | 962 |
| Density | 1.31 |
| Melting Point | 160 |
别名和识别编码
| Chemical Name | Nystatin, ≥4400 u/mg |
|---|---|
| MDL Number | MFCD25541651 |
| CAS Number | 1400-61-9 |
| EC Number | 215-749-0 |
| Synonym | Fungicidin mycostatin |
| Chemical Name Translation | 制霉菌素 |
| PubChem Substance ID | 11953884 |
| InChIKey | VQOXZBDYSJBXMA-RKEBNKJGSA-N |
| Wiswesser Line Notation | T-38-VO D&V GU IU MU OU QU SUTJ C1 D1 EQ F1 WQ A&VQB&Q F&Q G&Q J&Q L&Q N&Q UO- BT6OTJ CQ DZ |
| LabNetwork Molecule ID | LN02135329 |
| InChI | InChI=1S/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-35(65-47-45(60)42(48)44(59)30(4)64-47)26-39(56)41(46(61)62)38(55)24-34(52)23-37(54)36(53)20-19-31(49)21-32(50)22-33(51)25-40(57)63-29(3)28(2)43(27)58/h5-6,8,10-18,27-33,35-39,41-45,47,49-51,53-56,58-60H,7,9,19-26,48H2,1-4H3,(H,61,62)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27?,28?,29?,30-,31?,32?,33?,35?,36?,37?,38?,39?,41?,42+,43?,44-,45+,47?/m1/s1 |
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资金保障
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分类
- {SNA} Antibiotic Solutions, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antifungal, Biochemicals and Reagents, Cell Culture, Chemical Structure Class, Interferes with Cell Membrane Permeability (Ionophores), Mechanism of Action, Polyenes, Reagents and Supplements, Spectrum of Activity
- {SNA} Antibiotic Solutions, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antifungal, Biochemicals and Reagents, Chemical Structure Class, Interferes with Cell Membrane Permeability (Ionophores), Mechanism of Action, Polyenes, Spectrum of Activity,
- {SNA} Antibiotic Solutions,
产品应用
- 制霉菌素属多烯类抗真菌抗生素，具有强有力的促炎特性。它有许多应用，如防止细胞培养污染和诱导白细胞介素（IL） - ，IL-8，TLR2表达THP1分泌的细胞肿瘤坏死因子-α。它被用作为一种真菌膜（麦角甾醇结合）造孔剂以及在脂质双层中创建制霉菌素/对麦角甾醇的的离子通道。
相关文献及参考
- Merck: 14,6736
安全信息
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 24305 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher information, see AMACCQ. Volume(issue)/page/year: 3,697,1955/1956
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 10 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : APPHAX Acta Poloniae Pharmaceutica. For English translation, see APPFAR. (Ars Polona, POB 1001, 00-680 Warsaw 1, Poland) V.1- 1937- Volume(issue)/page/year: 30,81,1973
- H300 Fatal if swallowed 吞食致命
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H372 Causes damage to organs through prolonged or repeated exposure 长期或频繁接触会损伤器官
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P301+P316
- P304+P340
- P319
- P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
- P330 Rinse mouth. 漱口
- P403+P233
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
GHS Symbol
其他信息
- 溶于水。
