CAS 4205-91-8 MFCD00036705-Clonidine Hydrochloride 盐酸可乐定 TAO{mole}

Clonidine Hydrochloride 盐酸可乐定

CAS 4205-91-8 MFCD00036705

化学结构图

SMILES: Cl.Clc1cccc(Cl)c1NC1=NCCN1

化学属性

Mol. Formula	C9H10Cl3N3
Mol. Weight	267
TSCA	No
Appearance	可乐定盐酸盐，C9H9CI2N3·HCI，[4505-91-8]，Clonidine hydrochloride，Catapres。白色结晶性粉末，熔点305℃。溶于水、乙醇，几乎不溶于氯仿、乙醚。无臭。
Solubility	H2O: 50 mg/mL, clear, colorless
Melting Point	312

别名和识别编码

Chemical Name	Clonidine Hydrochloride
CAS Number	4205-91-8
Synonym	110降压片 2-(2,6-DICHLOROPHENYLAMINO)-2-IMIDAZOLINE HYDROCHLORIDE 2-(2,6-Dichloroanilino)-2-imidazoline Hydrochloride 2-(2,6-Dichloroanilino)-2-imidazoline hydrochloride 2-(2,6-Dichlorophenylamino)-2-imidazolin hydrochlorid 2-(2,6-Dichlorophenylamino)-2-imidazoline Hydrochloride 2-(2,6-dichloroanilino)-2-imidazolinmonohydrochloride 2-(2,6-dichlorophenylamino)-2-imidazolinhydrochlorid Atensina Catapres Catapresan Catapressan Chlophazolin Clofelin Clofenil Clonidine Clonidine Dihydrochloride Clonidine Hydrochloride Clonidine Monohydrobromide Clonidine Monohydrochloride Clopheline Dihydrochloride, Clonidine Dixarit Gemiton Haemiton Hemiton Hydrochloride, Clonidine Isoglaucon {PubChem}
MDL Number	MFCD00036705
Beilstein Registry Number	4163525
EC Number	224-121-5
PubChem Substance ID	20179
Merck Number	2390
Chemical Name Translation	盐酸可乐定
Reaxys-RN	4163525
Wiswesser Line Notation	T5M CN BUTJ BMR BG FG &GH
LabNetwork Molecule ID	LN01273348
InChI	InChI=1S/C9H9Cl2N3.ClH/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9;/h1-3H,4-5H2,(H2,12,13,14);1H

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品牌质保精细包装现货库存一流品牌服务

产品应用

Labelled Clonidine. ?2-Adrenergic agonist. Antihypertensive; analgesic for neuropathic pain.

安全信息

GHS Symbol

WGK Germany3

Precautionary statements

P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P284 Wear respiratory protection.? 佩戴呼吸保护装置。
P301+P310
P301+P310+P330
P301+P316
P304+P340
P304+P340+P310
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
P316
P320 Specific treatment is urgent (see … on this label). 紧急具体治疗（见本标签上的）。
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P403+P233
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H301 Toxic if swallowed 吞食有毒
H330 Fatal if inhaled 吸入致命

RTECSNJ2490000

Signal word Danger

Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Hazard Codes 6.1 T+

Safety Statements

S22 Do not breathe dust 不要吸入粉尘；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；

Risk Statements

R23 Toxic by inhalation 吸入有毒
R25 Toxic if swallowed 吞咽有毒
R26 Very toxic by inhalation 吸入极毒

UN Number 2811 UN 2811 6.1/PG 1

Packing GroupI

Hazard Class6.1

Storage condition 储存温度：2-8℃ 2-8°C 储存温度2-8°C

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PBPSDY Pharmacological and Biochemical Properties of Drug Substances.
   (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC
   20037)  V.1-    1977-  Volume(issue)/page/year: 1,67,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 17600 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 16,1038,1966

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 126 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
   Skin and Appendages - hair
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 18,366,1987

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 80 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 16,1038,1966

TYPE O

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - domestic
DOSE                    : 7500 ng/kg
SEX/DURATION            : female 16 week(s) after conception
TOXI

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - species unspecified
DOSE                    : 2080 ug/kg
SEX/DURATION            : female 8-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 31,10B,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Mammal - domestic
DOSE                    : 5 ug/kg
SEX/DURATION            : female 1 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
   Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
   ANESAV Anesthesiology.  (Lippincott/Harper, Journal Fulfillment Dept., 2350
   Virginia Ave., Hagerstown, MD 21740)  V.1-    1940- Volume(issue)/page/year:
   67,A448,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - domestic
DOSE                    : 5 ug/kg
SEX/DURATION            : female 1 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
   Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
   ANESAV Anesthesiology.  (Lippincott/Harper, Journal Fulfillment Dept., 2350
   Virginia Ave., Hagerstown, MD 21740)  V.1-    1940- Volume(issue)/page/year

其他信息

储运特性:库房通风低温干燥; 与氧化剂、碱类、食品添加剂分开存放
类别:有毒物质
毒性分级:高毒
急性毒性:口服- 大鼠 LD50: 126 毫克/ 公斤; 口服- 小鼠 LD50: 139 毫克/ 公斤
Sigma Aldrich:4205-91-8(sigmaaldrich)
图谱信息:盐酸可乐定(4205-91-8)质谱(MS) 盐酸可乐定(4205-91-8)红外图谱(IR2) 盐酸可乐定(4205-91-8)红外图谱(IR1) 盐酸可乐定(4205-91-8)核磁图( 13 CNMR) 盐酸可乐定(4205-91-8)Raman光谱盐酸可乐定(4205-91-8)核磁图( 1 HNMR)
盐酸可乐定价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 D1353 2-(2,6-二氯苯胺基)-2-咪唑啉盐酸盐 2-(2,6-Dichloroanilino)-2-imidazoline Hydrochloride 5G 2170元 2014/06/02 D1353 2-(2,6-二氯苯胺基)-2-咪唑啉盐酸盐 2-(2,6-Dichloroanilino)-2-imidazoline Hydrochloride 1G 724元
灭火剂:泡沫、水、二氧化碳、砂土
可燃性危险特性:可燃; 燃烧产生有毒氯化物和氮氧化物烟雾
用途一:抗高血压和戒烟戒毒药。
MOL 文件:4205-91-8.mol
F:10
TCI Shanghai:盐酸可乐定 2-(2,6-Dichloroanilino)-2-imidazoline Hydrochloride,>;98.0%(LC)(T)(4205-91-8)