7-Methylguanine 2-氨基-7-甲基-1H-嘌呤-6(7H)-酮

CAS 578-76-7 MFCD00038003

化学结构图

578-76-7
SMILES: Cn1cnc2nc(N)[nH]c(=O)c21

化学属性

Mol. FormulaC6H7N5O
Mol. Weight165.15

别名和识别编码

Chemical Name7-Methylguanine
CAS Number578-76-7
Synonym 2-Amino-1,7-dihydro-7-methyl-6H-purin-6-one 2-Amino-7-methylhypoxanthine 2-氨基-6-羟基-7-甲基嘌呤 2-氨基-6-羟基-7-甲基嘌呤 表鸟嘌呤 6H-Purin-6-one, 2-amino-1,7-dihydro-7-methyl- 7-Methylguanine 7-methylguanine 7-methylguanine, 14C-labeled N(2)-methylguanine N(sup 7)-Methylguanine N2-methylguanine N7-Me-G N7-Methylguanine N7-methylguanine NSC 193444 NSC 19647 {} {} {} {} {} {} {} {} {} {SNA} 7-甲基鸟嘌呤 表鸟嘌呤
MDL NumberMFCD00038003
PubChem Substance ID135398679
Beilstein Registry Number174245
EC Number209-431-0
Chemical Name Translation2-氨基-7-甲基-1H-嘌呤-6(7H)-酮
LabNetwork Molecule IDLN01289987
InChIInChI=1S/C6H7N5O/c1-11-2-8-4-3(11)5(12)10-6(7)9-4/h2H,1H3,(H3,7,9,10,12)
Canonical SMILESO=C1NC(N)=NC2=C1N(C)C=N2
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分类

  • Bases & Related Reagents
  • Nucleotides
  • {SNA} Building Blocks, Chemical Synthesis, Heterocyclic Building Blocks, Purines
  • Pharmaceuticals
  • Amines
  • Intermediates & Fine Chemicals,

产品应用

  • Has binding affinity to guanine deaminase, an important metalloenzyme in purine catabolism. Found in urine of patients with malignant cancer.

相关文献及参考

  • Fernandez, J. et al.; Bioorg. Med. Chem.; 18, 6748 (2010); Li, H. et al.; J. Mass. Spectrom. 44, 641 (2009)
  • [1]. Lee S, et al. Synthesis and structure of duplex DNA containing the genotoxic nucleobase lesion N7-methylguanine. J Am Chem Soc. 2008 Sep 3;130(35):11570-1.

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECSMF8464000
TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 1 gm/L
REFERENCE :
   ZAPOAK Zeitschrift fuer Allgemeine Mikrobiologie.  (Akademie-Verlag GmbH,
   Postfach 1233, Berlin DDR-1086 Ger. Dem. Rep.)  V.1-    1960-
   Volume(issue)/page/year: 12,583,1972

Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P305+P351+P338
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P332+P317
  • P337+P317
  • P362+P364

系列性分类


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