CAS 136-47-0 MFCD00038912-Tetracaine hydrochloride 丁卡因盐酸盐 TAO{mole}

Tetracaine hydrochloride 丁卡因盐酸盐

CAS 136-47-0 MFCD00038912

化学结构图

SMILES: Cl.CCCCNC1C=CC(=CC=1)C(=O)OCCN(C)C

化学属性

Mol. Formula	C15H24N2O2.HCl
Mol. Weight	300.83 g/mol
TSCA	No
Appearance	盐酸丁卡因(136-47-0)为白色结晶或结晶性粉末、无臭、味微苦，有麻舌感。盐酸丁卡因(136-47-0)在水中易溶，在乙醇中溶解，在乙醚或苯中不溶。盐酸丁卡因(136-47-0)熔点147-150℃。
Melting Point	147-150
Solubility	水中易溶，在乙醇中溶解，在乙醚或苯中不溶。

别名和识别编码

Chemical Name	Tetracaine hydrochloride
CAS Number	136-47-0
Synonym	######## 2-(DIMETHYLAMINO)ETHYL 4-(N-BUTYLAMINO)BENZOATE HYDROCHLORIDE 2-(Dimethylamino)ethyl 4-(n-butylamino)benzoate hydrochloride 2-(Dimethylamino)ethyl p-(butylamino)benzoate hydrochloride 2-(dimethylamino)ethylp-(butylamino)benzoatehydrochloride 2-DIMETHYLAMINOETHYL ESTER OFP-BUTYLAMINOBENZOIC ACID HYDROCHLORIDE 2-Dimethylaminoethanol 4-N-butylaminobenzoate hydrochlori 2-Dimethylaminoethyl 4-n-butylaminobenzoate hydrochloride; 4-(Butylamino)benzoic acid 2-(dimethylamino)et 2-dimethylaminoethanol4-n-butylaminobenzoatehydrochloride 4-(BUTYLAMINO)BENZOIC ACID 2-(DIMETHYLAMINO)ETHYL ESTER 4-(丁氨基) 4-(丁氨基)-苯甲酸-2-(二甲氨基)乙酯 4-(丁氨基)-苯甲酸-2-(二甲氨基)乙酯盐酸盐 4-BUTYLAMINOBENZOIC ACID DIMETHYLAMINOETHYL ESTER HCL 4-[BUTYLAMINO]BENZOIC ACID-2-[DIMETHYLAMINO]ETHYL ESTER HYDROCHLORIDE Amethocaine
MDL Number	MFCD00038912
PubChem Substance ID	87577427
EC Number	205-248-5
Merck Number	9188
Chemical Name Translation	丁卡因盐酸盐
Beilstein Registry Number	3918400
Reaxys-RN	3918400
Wiswesser Line Notation	4MR DVO2N1&1 &GH

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产品应用

A local anesthetic used topically in opthalmology.

安全信息

WGK Germany3

GHS Symbol

Precautionary statements

P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P310+P330
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P501 Dispose of contents/container to..… 处理内容物/容器.....
P405 Store locked up. 上锁保管。
P301+P310
P305+P351+P338
P305+P351+P338+P337+P313
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P337+P313

Hazard statements

H317 May cause an allergic skin reaction 可能导致皮肤过敏
H319 Causes serious eye irritation 严重刺激眼睛
H301 Toxic if swallowed 吞食有毒

Signal word

Hazard Codes T

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S24 Avoid contact with skin 避免皮肤接触；
S20 When using do not eat or drink 使用时，不得进食，饮水；
S22 Do not breathe dust 不要吸入粉尘；
S37 Wear suitable gloves 戴适当手套；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；

Risk Statements

R25 Toxic if swallowed 吞咽有毒
R36 Irritating to eyes 刺激眼睛
R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
R42/43

UN Number

RTECSDG4900000

Packing GroupIII

Storage condition 密封保存

Hazard Class6.1

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 19500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   QJPPAL Quarterly Journal of Pharmacy & Pharmacology.  (London, UK)  V.2-21,
   1929-48.  For publisher information, see JPPMAB.  Volume(issue)/page/year:
   20,380,1947

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6400 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,815,1995

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 4 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 7,739,1957

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 23 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARPMAS Archiv der Pharmazie (Weinheim, Germany)  (VCH Pub., Inc., 303 NW
   12th Ave., Deerfield Beach, FL 33441)  V.51-261, 1835-1923; V.305-    1972-
   Volume(issue)/page/year: 321,115,1988

TYPE OF TEST

其他信息

用途一:局部麻醉药。
用途二:盐酸丁卡因【136-47-0】局麻作用比普鲁卡因强，毒性亦较大，能透过粘膜，主要用于粘膜麻醉。
MSDS 信息:Tetracaine hydrochloride(136-47-0).msds
盐酸丁卡因价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 T1688 盐酸丁卡因 Tetracaine Hydrochloride 5G 310元 2014/06/02 T1688 盐酸丁卡因 Tetracaine Hydrochloride 25G 849元
MOL 文件:136-47-0.mol
Sigma Aldrich:136-47-0(sigmaaldrich)
TCI Shanghai:盐酸丁卡因 Tetracaine Hydrochloride,>;98.0%(LC)(T)(136-47-0)
图谱信息:盐酸丁卡因(136-47-0)核磁图( 13 CNMR) 盐酸丁卡因(136-47-0)质谱(MS) 盐酸丁卡因(136-47-0)红外图谱(IR2) 盐酸丁卡因(136-47-0)红外图谱(IR1) 盐酸丁卡因(136-47-0)核磁图( 1 HNMR)