CAS 86-50-0 MFCD00041814-Azinphos-methyl 保棉磷 TAO{mole}

Azinphos-methyl 保棉磷

CAS 86-50-0 MFCD00041814

化学结构图

SMILES: COP(=S)(OC)SCn1nnc2ccccc2c1=O

化学属性

Mol. Formula	C10H12N3O3PS2
Mol. Weight	317.32
Density	0.791
Solubility	不溶于水，易溶于多数有机溶剂。

别名和识别编码

Chemical Name	Azinphos-methyl
Synonym	1,2,3-benzotriazin-4(3h)-one,3-(mercaptomethyl)-,o,o-dimethylphosphorodith 1,2,3-benzotriazine, phosphorodithioic acid deriv. 2,3-benzotriazin-4(3h)-one 3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-ylmethyl O,O-dim 3-(Mercaptomethyl)-1,2,3-benzotriazin-4(3H)-one O,O-dimethyl phosphorodithioate S-ester 3-(mercaptomethyl)-1,2,3-benzotriazin-4(3h)-oneo,o-dimethylphosphorodithioate O,O-dimethy-S-[(4-oxo-1,2,3-benzotriazin-3(4H)-yl)methyl] phosphorodithioate O,O-dimethy-S-[(4-oxo-1,2,3-benzotriazin-3(4H)-yl)methyl]phosphorodithioate AZINPHOS-METHYL Azinphos Methyl Azinphos-Methyl Azinphos-methyl (ISO) Azinphosmethyl BAY 17147 Bayer 17147 Cotneon Cotnion ENT 23,233 Gusathion 20 Gusathion 25 {PubC
MDL Number	MFCD00041814
PubChem Substance ID	2268
Beilstein Registry Number	280476
CAS Number	86-50-0
EC Number	201-676-1
Chemical Name Translation	保棉磷
Merck Number	13,915
Wiswesser Line Notation	T66 BNNNVJ D1SPS&O1&O1
InChI	InChI=1S/C10H12N3O3PS2/c1-15-17(18,16-2)19-7-13-10(14)8-5-3-4-6-9(8)11-12-13/h3-6H,7H2,1-2H3

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安全信息

RTECSTE1925000

GHS Symbol

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P284 Wear respiratory protection.? 佩戴呼吸保护装置。
P301+P310
P302+P350
P302+P352
P304+P340
P305+P351+P338
P307+P311
P308+P313
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
P320 Specific treatment is urgent (see … on this label). 紧急具体治疗（见本标签上的）。
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P333+P313
P337+P313
P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P403+P233
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H300 Fatal if swallowed 吞食致命
H300+H330
H310 Fatal in contact with skin 皮肤接触致命
H311 Toxic in contact with skin 皮肤接触中毒
H317 May cause an allergic skin reaction 可能导致皮肤过敏
H330 Fatal if inhaled 吸入致命
H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。

Hazard Codes T+,N

WGK Germany3

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Signal word Danger

Storage condition 2-8℃ 0-6°C 储存温度2-8℃

Packing GroupII

Hazard Class6.1(a)

UN Number 2783

Safety Statements

S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；

Risk Statements

R24 Toxic in contact with skin 与皮肤接触有毒
R26/28 Very toxic by inhalation and if swallowed 吸入及吞食都有剧毒
R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
R50/53

Restrict {} 剧毒化学品危险品

Warnings 危化品目录(2015)

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 121 gm/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   JEPTDQ Journal of Environmental Pathology and Toxicology.  (Park Forest
   South, IL)  V.1-5(3), 1977-81(?).  For publisher information, see JEPOEC.
   Volume(issue)/page/year: 1(6),829,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5110 mg/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Gastrointestinal - tumors
   Endocrine - thyroid tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-69,1978

{hazard_c

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : >280 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle weakness
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   KUMJAX Kumamoto Medical Journal.  (Kumamoto Univ. Medical School, 2-2-1
   Honjo, Kumamoto 860, Japan) V.1-    1938-  Volume(issue)/page/year:
   12,313,1959

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - wild bird species
DOSE/DURATION           : 8500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   21,315,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PEMNDP Pesticide Manual.  (The British Crop Protection Council, 20 Bridport
   Rd., Thornton Heath CR4 7QG, UK)  V.1-    1968-  Volume(issue)/page/year:
   9,46,1991

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 8600 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PESTD5 Proceedings of the European Society of Toxicology.  (Amsterdam,
   Netherlands)  V.16-18, 1975-77.  Discontinued.  Volume(issue)/pa

TYPE OF TEST            : LD50 - Lethal dose, 50 pe

TYPE OF TE

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 10 mg/L
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB84-138973

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 120 mg/L
REFERENCE :
   CNJGA8 Canadian Journal of Genetics and Cytology.  (National Research
   Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6,

TYPE OF TEST            : Micronucleus test
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 60 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 388,27,1997

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Schizosaccharomyces pombe
DOSE/DURATION           : 25 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 117,139,1983

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 10 umol/L
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 10 gm/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 321,203,1994

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 20 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis.  (Alan R. Liss, Inc.,
   41 E. 11th St., New York, NY 10003)  V.1-    1980- Volume(issue)/page/year:
   5,3,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 190 mg/kg
SEX/DURATION            : female 6-22 day(s) after conception
                          lactating female 21 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
   per # born alive)
   Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
   alive at weaning per # alive at day 4)
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   43,177,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 85 mg/kg
SEX/DURATION            : female 6-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB288-457

TYPE OF TEST            : TDLo - Lowest published toxic dos

其他信息

灭火剂:砂土、干粉、泡沫
储运特性:库房通风低温干燥; 与食品原料分开储运
刺激数据:眼睛-兔子 24.4 毫克重度
Sigma Aldrich:86-50-0(sigmaaldrich)
类别:农药
注意事项:本产品有效成分1-甲基环丙烯为无色且不稳定的气体，其本身无法单独作为一种产品存在。该气体一经生成，便即刻与α-环糊精吸附，形成一种十分稳定的吸附混合物，并根据所需浓度，直接加工成所需制剂。所以本产品不存在高浓度原药。
职业标准:TWA 0.2 毫克/立方米; STEL 0.6 毫克/立方米
毒性分级:剧毒
杀虫剂单一组分标准液
急性毒性:口服-大鼠 LD50: 7 毫克/公斤; 口服-小鼠 LD50: 8.6 毫克/公斤
美国环保局和新西兰环境风险管理局决定淘汰保棉磷的使用:保棉磷（谷硫磷）是一种神经毒素，具有良好的杀虫效力，用于如草莓，夏日水果和马铃薯等作物的虫害防治，属于广谱有机磷杀虫剂。但是美国环保局认为，它对农场工人而言带有无法接受的风险并也在扩散到水里时杀死了鱼。美国环保局决定，2012年夏天之后任何人不得使用保棉磷。而樱桃种植者是最后一批使用保棉磷的农户之一。50年来，种植者一直依靠保棉磷使水果不受蠕虫和驱虫之害。保棉磷来源于一战的神经毒气。当他们喷洒保棉磷的时候，果园里的每只小虫子都必死无疑。一小部分种植者一直在试图寻找保棉磷的替代品。新西兰环境风险管理局(ERMA)一直将保棉磷的使用评估作为更广泛的化合物审查的一部分，并决定在5年内将之逐步淘汰出市,该机构还将在这段时间内加强控制，以减少对人和环境造成的威胁。这些措施包括禁止国内使用或空中喷洒，并限制一年中的使用次数。ERMA称将淘汰期设定为5年是因为这是发展替代产品所需要的时间。
可燃性危险特性:明火可燃; 受热放出有毒氧化硫、氧化氮、氧化磷气体
MSDS 信息:保棉磷(86-50-0).msds
MOL 文件:86-50-0.mol
外观性质:白色晶体, 商品有2.5%粉剂、25%可湿性粉剂及20%—40%乳剂。
图谱信息:保棉磷(86-50-0)质谱(MS) 保棉磷(86-50-0)核磁图( 13 CNMR) 保棉磷(86-50-0)核磁图( 1 HNMR)