CAS 1563-66-2 MFCD00041819-Carbofuran 呋喃丹 TAO{mole}

Carbofuran 呋喃丹

CAS 1563-66-2 MFCD00041819

化学结构图

SMILES: CNC(=O)Oc1cccc2c1OC(C)(C)C2

化学属性

Mol. Formula	C12H15NO3
Mol. Weight	221.25
Melting Point	150-153 °C(lit.)
Boiling Point	200°C
Density	1.18
Solubility	微溶于水，溶于多数有机溶剂。

别名和识别编码

Chemical Name	Carbofuran
CAS Number	1563-66-2
Synonym	2 2,2-Dimethyl-2,2-dihydrobenzofuranyl-7-N-methylcarbamate 2,2-Dimethyl-2,2-dihydrobenzofuranyl-7-N-methylcarbamate; 2,2-Dimethyl-2,3-dihydrobenzofuranyl 7-methylcarbamate; 2,3-Dihydro-2,2-dimethyl-7-benzofuranol methylcarbamate; Methylcarbamic acid 2,2-dimethyl-2,3-dihydro-7-benzofuran 2,2-Dimethyl-2,3-dihydro-7-benzofuranyl N-methylcarbamate 2,2-dimethyl-2,3-dihydrobenzofuranyl 7-methylcarbamate 2,3-DIHYDRO-2,2-DIMETHYL-BENZOFURAN-7-YL METHYLCARBAMATE 2,3-Dihydro-2,2-dimethyl-7-benzofuranol methylcarbamate 2,3-Dihydro-2,2-dimethyl-7-benzofuranole methylcarbamate 2,3-Dihydro-2,2-dimethyl-7-benzofuranyl N-methylcarbamate 2,3-Dihydro-2,2-dimethyl-7-benzofuranyl methylcarbamate 2,3-Dihydro-2,2-dimethyl-7-benzofuranyl-N-methylcarbamat 2,3-Dihydro-2,2-dimethylbenzofuran-7-yl methylcarbamate 2,3-dihydro-2,2-
MDL Number	MFCD00041819
PubChem Substance ID	2566
Beilstein Registry Number	1428746
EC Number	216-353-0
Chemical Name Translation	呋喃丹
Merck Number	13,1813
Wiswesser Line Notation	T56 BOT&J C1 C1 IOVM1
InChI	InChI=1S/C12H15NO3/c1-12(2)7-8-5-4-6-9(10(8)16-12)15-11(14)13-3/h4-6H,7H2,1-3H3,(H,13,14)

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产品应用

呋喃丹是氨基甲酸酯类广谱内吸杀虫杀螨杀线虫剂，可用于多种作物防治土壤内及地面上的300多种害虫和线虫。并有所短作物生长期、促进作物生长发育从而有效提高作物产量的作用。呋喃丹对昆虫的致毒方式，主要是内吸杀虫作用。药剂施于土壤作物的根基部分，根系吸收后随水份数栋到茎叶部，以达到治虫的目的、呋喃丹还有触杀作用。用于防治棉花蚜虫，水稻，玉米根虫，对水稻、玉米、和花生等作物大部分害虫有效。

安全信息

GHS Symbol

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P284 Wear respiratory protection.? 佩戴呼吸保护装置。
P301+P310
P302+P352
P304+P340
P304+P340+P310
P307+P311
P308+P313
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
P320 Specific treatment is urgent (see … on this label). 紧急具体治疗（见本标签上的）。
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P403+P233
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H300 Fatal if swallowed 吞食致命
H300+H330
H330 Fatal if inhaled 吸入致命
H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。

WGK Germany3

Signal word Danger

Hazard Codes T+,N,T T+,N T;N

Safety Statements

S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S1/2 None 上锁保管并避免儿童触及；

Risk Statements

R26/28 Very toxic by inhalation and if swallowed 吸入及吞食都有剧毒
R50/53

UN Number 2757 UN 2811 6.1/PG 1

Packing GroupI

Hazard Class6.1(a)

Storage condition 0-6°C

RTECSFB9450000

Restrict 剧毒化学品

Warnings 危化品目录(2015) 危险化学品

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 85 mg/m3
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Gastrointestinal - changes in structure or function of salivary glands
   Gastrointestinal - nausea or vomiting
REFERENCE :
   JJOMDZ JOM, Journal of Occupational Medicine.  (American Occupational
   Medicine Assoc., 150 N. Wacker Dr., Chicago, IL 60606)  V.10-    1968-
   Volume(issue)/page/year: 12,16,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 19 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 49(10),23,1984

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 52 mg/m3
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Gastrointestinal - changes in structure or function of salivary glands
   Gastrointestinal - nausea or vomiting
REFERENCE :
   JJOMDZ JOM, Journal of Occupational Medicine.  (American Occupational
   Medicine Assoc., 150 N. Wacker Dr., Chicago, IL 60606)  V.10-    1968-
   Volume(issue)/page/year: 12,16,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Bird - wild bird species
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose v

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 10 mg/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 116,185,1983

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 60 mg/L
REFERENCE :
   MILEDM Microbios Letters.  (Faculty Press, 88 Regent St., Cambridge, UK)
   V.1-    1976-  Volume(issue)/page/year: 12,79,1979

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 500 umol/L
REFERENCE :
   ENVRAL Environmental Research.  (Academic Press, Inc., 1 E. First St.,
   Duluth, MN 55802) V.1-    1967-  Volume(issue)/page/year: 29,48,1982

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 100 mg/L
REFERENCE :
   TGANAK Tsitologiya i Genetika.  Cytology and Genetics.  For English
   translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-    1967-  Volume(issue)/page/year: 18(1),17,1984

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 5 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 147,296,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 210 ug/kg
SEX/DURATION            : female 1-21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
   JEPTDQ Journal of Environmental Pathology and Toxicology.  (Park Forest
   South, IL)  V.1-5(3), 1977-81(?).  For publisher information, see JEPOEC.
   Volume(issue)/page/year: 2(2),357,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 10500 ug/kg
SEX/DURATION            : female 1-21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - immune and
   reticuloendothelial system
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
   Reproductive - Effects on Newborn - delayed effects
REFERENCE :
   JEPTDQ Journal of Environmental Pathology and Toxicology.  (Park Forest
   South, IL)  V.1-5(3), 1977-81(?).  For publisher information, see JEPOEC.
   Volume(issue)/page/year: 4(5-6),53,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 70 mg/kg
SEX/DURATION            : female 6-19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food
   Contaminants, and Agricultural Wastes.  (Marcel Dekker, 270 Madison Ave.,
   New York,

其他信息

用途五:广谱、高效、低残留、高毒性的氨基甲酸酯类杀虫、杀螨、杀线虫剂。具有内吸、触杀、胃毒作用，并有一定的杀卵作用，持效期较长，一般在土壤中半衰期为30～60d。可用于防治水稻螟虫、稻蓟马、稻纵卷叶虫、稻飞虱、稻叶蝉、稻象甲、玉米螟、玉米切根虫、棉蚜、棉铃虫、大豆蚜、大豆食心虫、螨类及线虫等。一般用量为6.8～10g有效成分/100m 2 ,或3%颗粒剂225～300g/100m 2 。棉花种子处理可先将棉种经硫酸脱绒，再用35%种衣剂（有效成分为种子干重1%）包衣处理，可防治棉蚜、地老虎等害虫。
可燃性危险特性:遇明火、高热可燃; 受热产生有毒氮氧化物烟雾
呋喃丹使用方法:(1)防治棉花苗期害虫：每亩用3%颗粒剂1.5～2公斤，与种子同时撒入沟内，或用3%颗粒剂拌干棉籽，用药量为药1份、棉籽4份。 (2)防治烟草田害虫：防治烟草的烟蚜、根结线虫、小地老虎、蝼蛄等害虫，于烟苗移栽时，用3%颗粒剂，每穴撒1—1.5克。 (3)防治水稻田害虫：防治稻螟、飞虱、蓟马、叶蝉、稻瘿蚊等害虫，每亩用3％颗粒剂1．5～2公斤，对细沙15公斤，拌匀撤于水面；在陆稻田每亩用3％颗粒剂2～2．5公斤，与稻种同时播下。 (4)防治大豆田害虫：防治蚜虫、豆杆蝇及孢囊线虫等，每亩用3％颗粒剂2．2～4．4公斤，撒于播种沟内。 (5)防治花生田害虫：防治蚜虫、蓟马、蝼蛄及根结线虫等。每亩用3％颗粒剂4
中毒症状:头昏、头痛、乏力、面色苍白、呕吐、多汗、流涎、瞳孔缩小、视力模糊。严重者出现血压下降、意识不清，皮肤出现接触性皮炎如风疹，局部红肿痛痒，眼结膜
类别:农药
上游原料:亚硝酸钠 --> 三乙胺 --> 苯 --> 氯 --> 四氯化碳 --> 氨基苯 --> 一甲胺 --> 光气(无法供) --> 邻苯二酚 --> 聚乙烯醇 --> 呋喃 --> 氯化镁 --> 氧茚 --> 2-硝基苯酚 --> 异氰酸甲酯 --> 呋喃酚 --> 3-氯-2-甲基丙烯 --> 稳定剂 --> 甲胺基甲酰氯 --> 无水丙酮 --> 甲基异氰酸酯 --> 钯碳催化剂
用途四:用于防治棉花、水稻、玉米、花生、谷物、香蕉、咖啡、甜菜、烟草等作物的害虫
灭火剂:水、泡沫、二氧化碳
外观性质:纯品为白色无臭结晶，工业品稍有苯酚气味。
用途三:有优良的抗静电和防腐蚀性，有较好的分散、乳化、起泡作用，也可用作生产餐巾纸和卫生纸的助剂
下游产品:呋喃酚 --> 种衣剂 --> 丁硫克百威 --> 苯并呋喃硫酰氯
Sigma Aldrich:1563-66-2(sigmaaldrich)
毒性:大鼠急性经口 LD 50 为8～14mg/kg(工业品为1.0mg/kg)，急性经皮LD 50 <500mg/kg。狗急性经口LD 50 为19mg/kg，鸡为9mg/kg。鳟鱼LC 50 1.5mg/L (0.28mg/kg) (96h)，工业品对鲶鱼、青锶鱼
注意事项:[1]呋喃丹毒性高，贮存、运输及施药时，必须按高毒农药规定。 [2]直播田施用呋喃丹，不能与敌稗、灭草灵等除草剂同时混用，施用敌稗应在施用呋喃丹前3－4天进行，或在施用呋喃丹后一个月施用。 [3]呋喃丹在水中水解速度随pH值及温度升高而加快，故不能与碱性农药、肥料混合施用，否则易分解失效
方法一:由邻硝基苯酚出发氯化反应异丙烯在一定压力下氯化，制得甲基氯丙烯。氯化反应液经压滤、蒸馏等后处理，产物纯度可达96%。醚化反应邻硝基苯酚与甲基氯丙烯在碳酸钠存在下制得2-甲代烯丙基邻硝基酚醚。克莱逊反应 2-甲代烯丙基邻硝基酚醚加热，经克莱逊反应转位生成2-（2-甲代烯丙基）-6-硝基苯酚。环合反应在无水氯化镁存在下，克莱逊重排产物环合成2，3-二氢-2，2-二甲基-7-硝基苯并呋喃（俗称7-硝基）。加氢反应将7-硝基在钯/碳催化剂存在下，加压还原制得2，3-二氢-2，2-二甲基-7-氨基苯并呋喃（俗称7-氨基）。重氮化反应 7-氨基与亚硝酸钠水溶液、浓硫酸进行重氮化反应，制得2，3-二氢-2，2-二甲基-7-苯并呋喃重氮硫酸盐（俗称7-重氮硫酸盐）。水解反应 7-重氮硫酸盐在CuSO4催化作用下水解成2，3-二氢-