Benzyl carbazate 肼基甲酸苄酯

CAS 5331-43-1 MFCD00041890

化学结构图

5331-43-1
SMILES: NNC(=O)OCc1ccccc1

化学属性

Mol. FormulaC8H10N2O2
Mol. Weight166.18
Melting Point65-68°C
TSCAYes
Flash Point110°C
Boiling Point294.38 °C at 760 mmHg

别名和识别编码

Chemical NameBenzyl Carbazate
CAS Number5331-43-1
Synonym Benzyl hydrazinecarboxylate {LY} Benzyl hydrazinecarboxylate {} {LY} Benzyl hydrazinecarboxylate {} {} {LY} Benzyl hydrazinecarboxylate {} {} {} {LY} Benzyl hydrazinecarboxylate {} {} {} {} {LY} Benzyl hydrazinecarboxylate {} {} {} {} {} {LY} Benzyl hydrazinecarboxylate {} {} {} {} {} {} {LY} Benzyl hydrazinecarboxylate {} {} {} {} {} {} {} {LY} Benzyl hydrazinecarboxylate {} {} {} {} {} {} {} {} {LY} Benzyl hydrazinecarboxylate {} {} {} {} {} {} {} {} {} {LY} Benzyl hydrazinecarboxylate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Benzyl hydrazinecarboxylate {} {} {} {} {} {} {} {} {} {} {} {LY} Benzyl hydrazinecarboxylate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Benzyl hydrazinecarboxylate {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Benzyl hydrazinecarboxylate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Benzyl hydrazin
PubChem Substance ID79242
EC Number226-230-3
Beilstein Registry Number1952982
MDL NumberMFCD00041890
Reaxys-RN1952982
Chemical Name Translation肼基甲酸苄酯
InChIKeyRXUBZLMIGSAPEJ-UHFFFAOYSA-N
LabNetwork Molecule IDLN00007843
Canonical SMILESNNC(OCC1=CC=CC=C1)=O
InChIInChI=1S/C8H10N2O2/c9-10-8(11)12-6-7-4-2-1-3-5-7/h1-5H,6,9H2,(H,10,11)
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分类

  • {SNA} Amine Protection, Chemical Biology, Chemical Synthesis, Others, Peptide Chemistry, Protecting and Derivatizing Reagents, Protection and Derivatization, Synthetic Reagents
  • Amine Protection, Chemical Biology, Chemical Synthesis, Others, Peptide Chemistry, Protecting and Derivatizing Reagents, Protection and Derivatization, Synthetic Reagents
  • {SNA} Amine Protection, Chemical Biology, Chemical Synthesis, Other Protecting and Derivatizing Reagents, Peptide Chemistry, Protecting and Derivatizing Reagents, Protection and Derivatization, Synthetic Reagents

产品应用

  • Benzyl Carbazate has been shown to prevent the occurrence of oligonucleosome-sized DNA fragmentation in the cell-free system.

相关文献及参考

  • Reagent for preparation of benzyloxycarbonyl (Z, Cbz) hydrazides of carboxylic acids, particularly N-protected amino acids. Subsequent hydrogenolysis gives the hydrazide which can be converted to the azide for coupling with a further amino acid residue by the azide method: J. Am. Chem. Soc., 74, 470 (1952); 87, 620 (1965); see Appendix 6:
  • Has also been used in a similar manner for the preparation of simple acyl or sulfonyl hydrazides avoiding diacylation; the residual benzyl group is removable by hydrogenolysis: Synthesis, 244 (1980).
  • Reagent for preparation of benzyloxycarbonyl (Z, Cbz) hydrazides of carboxylic acids, particularly N-protected amino acids. Subsequent hydrogenolysis gives the hydrazide which can be converted to the azide for coupling with a further amino acid residue by the azide method: J. Am. Chem. Soc., 74, 470 (1952); 87, 620 (1965); see Appendix 6:
  • Beilstein: 6,III,1530
  • Has also been used in a similar manner for the preparation of simple acyl or sulfonyl hydrazides avoiding diacylation; the residual benzyl group is removable by hydrogenolysis: Synthesis, 244 (1980).
  • Sane, A.-T. et al.: Cancer Res., 58, 3066 (1998);

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H318 Causes serious eye damage 严重伤害眼睛
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H372 Causes damage to organs through prolonged or repeated exposure 长期或频繁接触会损伤器官
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xi
RTECSMV1724950
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P301+P317
  • P302+P350
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P310
  • P305+P354+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医,如果你觉得不舒服
  • P317
  • P319
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P337+P313
  • P337+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word
Safety Statements
Risk Statements
  • R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

其他信息

  • MOL 文件:5331-43-1.mol
  • Alfa Aesar:肼基甲酸苄酯,98+% Benzyl carbazate, 98+%(5331-43-1)
  • 下游产品:4-肼基哌啶-1-羧酸叔丁酯
  • Acros Organics:肼基甲酸苄酯 Carbobenzoxyhydrazide, 98%(5331-43-1)
  • Sigma Aldrich:5331-43-1(sigmaaldrich)
  • 肼基甲酸苄酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xw010159 肼基甲酸苄酯 25g 1000元 2011/04/16 C1564 肼基甲酸苄酯 Benzyl Carbazate 5G 575元 2011/04/16 C1564 肼基甲酸苄酯 Benzyl Carbazate 25G 1890元
  • TCI Shanghai:肼基甲酸苄酯 Benzyl Carbazate,>;98.0%(T)(5331-43-1)
  • MSDS 信息:Carbobenzoxyhydrazide(5331-43-1).msds

系列性分类


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