Nonactin 无活菌素
CAS 6833-84-7 MFCD00043039
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资金保障
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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现货库存
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分类
- {SNA} Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antimycobacterial, Antineoplastic and Immunosuppressive Antibiotics, Chemical Structure Class, Interferes with Cell Membrane Permeability (Ionophores), Interferes with DNA Synthesis, Macrolides, Mechanism of Action, Spectrum of Activity, 抗生素, 生化试剂
- {SNA} Antibacterial, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antimycobacterial, Antineoplastic and Immunosuppressive Antibiotics, Chemical Structure Class, Inhibits an Enzyme, Interferes with Cell Membrane Permeability (Ionophores), Interferes with DNA Synthesis,
产品应用
- Nonactin has an inhibitory effects on the P170 glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug-resistant cancer cells.
- Nonactin, a natural mixture of macrotetrolides, was used in agriculture under the name trade POLYNACTIN.
- Nonactin has been reported to specifically inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria.
- Nonactin is used in urea and ammonium specific electrodes.
相关文献及参考
- [2]. Shikata Y, et al. Mitochondrial uncoupler exerts a synthetic lethal effect against β-catenin mutant tumor cells. Cancer Sci. 2017 Apr;108(4):772-784.
- [3]. Barazi HO, et al. Identification of heat shock protein 60 as a molecular mediator of alpha 3 beta 1 integrin activation. Cancer Res. 2002 Mar 1;62(5):1541-8.
- Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15
- Short: III/5b Title: Structure Data of Organic Crystals: C 14 ... C 120 Author: Schudt, E.; Weitz, G. Editor: Hellwege, K.-H.; Hellwege, A.M. Source: Landolt-Börnstein, New Series Volume: III/5b Year: 1971 ISBN: 3-540-05177-5 ISBN: 978-3-540-05177-0 Internet Resource: DOI:10.1007/b19970 RefComment: XXI, 736 pages, and VII, 890 pages. Hardcover
安全信息
GHS Symbol
- S22 Do not breathe dust 不要吸入粉尘;
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
- P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 246 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 2,393,1980
其他信息
- Nonactin from Streptomyces Griseus: a mixture of the two homolog macrotetrolide antibiotics: Nonactin, Monactin. The Nonactin is not less than 80%, ballanced by Monactin only. The mixture does not contain Dinactin, Trinactin, Tetranactin. Nonactin batches released since May 2010 are better than 95% Nonactin by NMR; detailed information is available on request