CAS 551-92-8 MFCD00047046-1,2-Dimethyl-5-Nitroimidazole 二甲硝咪唑 TAO{mole}

1,2-Dimethyl-5-Nitroimidazole 二甲硝咪唑

CAS 551-92-8 MFCD00047046

化学结构图

SMILES: Cc1ncc([N+](=O)[O-])n1C

化学属性

Mol. Formula	C5H7N3O2
Mol. Weight	141.13
Melting Point	177-182°C
TSCA	No
Density	1.36
Appearance	浅黄色针状结晶性粉末，无味。熔点138-139℃。溶于氯仿、乙醇、稀碱合稀酸，不溶于水合乙醚。盐酸盐溶于水合乙醇，微溶于丙酮。
Boiling Point	258.15 °C at 760 mmHg

别名和识别编码

Chemical Name	1,2-Dimethyl-5-Nitroimidazole
Synonym	Dimetridazole {LY} Dimetridazole {} {LY} Dimetridazole {} {} {LY} Dimetridazole {} {} {} {LY} Dimetridazole {} {} {} {} {LY} Dimetridazole {} {} {} {} {} {LY} Dimetridazole {} {} {} {} {} {} {LY} Dimetridazole {} {} {} {} {} {} {} {LY} Dimetridazole {} {} {} {} {} {} {} {} {LY} Dimetridazole {} {} {} {} {} {} {} {} {} {LY} Dimetridazole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Dimetridazole {} {} {} {} {} {} {} {} {} {} {} {LY} Dimetridazole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Dimetridazole {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Dimetridazole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Dimetridazole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Dimetridazole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
CAS Number	551-92-8
MDL Number	MFCD00047046
PubChem Substance ID	3090
Beilstein Registry Number	130665
EC Number	209-001-2
Merck Number	3265
Reaxys-RN	130665
Chemical Name Translation	二甲硝咪唑
Wiswesser Line Notation	T5N CNJ A1 B1 ENW
InChI	InChI=1S/C5H7N3O2/c1-4-6-3-5(7(4)2)8(9)10/h3H,1-2H3
LabNetwork Molecule ID	LN00198834
Canonical SMILES	O=[N+](C1=CN=C(C)N1C)[O-]

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

二甲硝咪唑对黑头组织滴虫、牛毛滴虫，结肠小袋虫、鞭毛虫等，及坏死厌氧丝杆菌、梭状芽胞杆菌、厌氧葡萄球菌、肠弧菌、密螺旋体菌等细菌，具有显著抑制作用，是治疗火鸡黑头病及猪赤痢的有效药物。

安全信息

RTECSNI5075000

GHS Symbol

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P302+P352
P302+P352+P332+P313+P362+P364
P304+P340
P305+P351+P338
P305+P351+P338+P337+P313
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P332+P313
P337+P313
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P403+P233
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H335 May cause respiratory irritation 可能导致呼吸道刺激

WGK Germany3

Signal word Warning

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Safety Statements

S22 Do not breathe dust 不要吸入粉尘；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36 Wear suitable protective clothing 穿戴适当的防护服；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

Hazard Codes Xi

Storage condition 2-8°C {LY} 2-8°C 2-8℃保存 {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 50 gm/kg/46W-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   51,403,1973

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 10 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier S

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Klebsiella pneumoniae
DOSE/DURATION           : 50 umol/L/20H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 66,207,1979

TYPE OF TEST            : Body fluid assay
TEST SYSTEM             : Rodent - rat Bacteria - Salmonella typhimurium
DOSE/DURATION           : 800 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 97,171,1982

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 500 ppm
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 86,243,1981

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 100 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 26,483,1974

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 25 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 38,203,1976

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacte

其他信息

Alfa Aesar:1，2-二甲基-5-硝基咪唑,97% 1,2-Dimethyl-5-nitroimidazole, 97%(551-92-8)
用途三:二甲硝咪唑对黑头组织滴虫、牛毛滴虫、结肠小袋虫、鞭毛虫等原虫，及坏死厌氧丝杆菌、梭状芽胞杆菌、厌气葡萄球菌、肠弧菌、密螺旋体菌等细菌，具有显著抑制作用，是治疗火鸡黑头病及猪赤痢的有效药物。该品也可作为生长促进剂，用以促进猪、鸡的生产及提高饲料转化率。该品作为饲料添加剂时，在饲料加工时先把本品与10-20倍饲料量预混，然后再与所需的饲料总量均匀混合。或者先把本品与适量的载体混合，然后加进饲料里搅拌。在加工配合饲料时，造粒及其他操作过程对本品的效果没有影响。该品可拌入饲料，也可添加于饮水中供畜禽饮用。甲硝咪唑毒性低，动物耐
用途二:是畜禽促生长剂和高效、低毒的广谱抗原虫药。可用于猪饲料，用量50-100g/t；也可用于鸡饲料，用量125-200g/t。
用途四:二甲硝咪唑对黑头组织滴虫、牛毛滴虫，结肠小袋虫、鞭毛虫等，及坏死厌氧丝杆菌、梭状芽胞杆菌、厌氧葡萄球菌、肠弧菌、密螺旋体菌等细菌，具有显著抑制作用，是治疗火鸡黑头病及猪赤痢的有效药物。
二甲硝咪唑价格(试剂级):更新日期产
遇光渐变黑，无臭或基本无臭。溶于氯仿、乙醇、稀碱和稀酸；不溶于水、乙醚。
上游原料:硝酸 --> 硫酸二甲酯 --> 乙二醛 --> 工业硫酸 --> 三口烧瓶 --> 2-甲基咪唑 --> 2-甲基-5-硝基咪唑 --> 2-甲基咪唑啉 --> 甲硝咪唑
方法二:以乙二醛为起始原料，与乙醛、氨环合，得2-甲基咪唑（C4H5N2，[693--98-1]）。然后硝化，得2-甲基-5-硝基咪唑（C4H6N3O2，[696-23-1]。最后以硫酸二甲酯甲基化即得甲硝咪唑。中间体2-甲基咪唑也可由乙二胺与乙腈环合得到2-甲基咪唑啉，然后加活性镍催化脱氢而得。
Sigma Aldrich:551-92-8(sigmaaldrich)
图谱信息:二甲硝咪唑(551-92-8)红外图谱(IR2) 二甲硝咪唑(551-92-8)质谱(MS) 二甲硝咪唑(551-92-8)Raman光谱二甲硝咪唑(551-92-8)红外图谱(IR1)
二甲硝咪唑价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 D1564 1,2-二甲基-5-硝基咪唑 1,2-Dimethyl-5-nitroimidazole 500G 1870元 2014/06/02 D1564 1,2-二甲基-5-硝基咪唑 1,2-Dimethyl-5-nitroimidazole 25G 272元 2010/05/25 L11303 1，2-二甲基-5-硝基咪唑, 97% 1,2-Dimethyl-5-nitro
用途一:是高效、低毒、超广谱抗菌、抗原虫的治疗或预防药物
方法一:以2-甲基咪唑为原料，经硝化、甲酯化而得。将40g尿素溶于100mL水中，加入40mL浓硝酸，得溶液Ⅰ。控制温度小于50℃，将70g2-甲基咪唑缓慢加入200mL工业硫酸中，得到溶液Ⅱ。将溶液Ⅱ慢慢倒入溶液Ⅰ中，在室温下放置24h，然后搅拌升温至80℃反应2h，升温至110℃反应0.5h。冷却至80℃滴加浓硝酸200mL，升温至120℃搅拌反应2h，最后于150℃以下蒸出多余的硝酸。冷却至40℃，用400mL水稀释，氨水调PH=3.5-4.0。冷至室温，经过滤、水洗、干燥、得2-甲基-5-硝基咪唑83.8g（熔点248-250℃），产率77.3%。在三口烧瓶中加入上述产品50g和85%的甲酸60mL，加热至80℃，于30min内滴加硫酸二甲酯[（CH3）2SO4]60g，随后反应0.5h。然后蒸去溶剂，加入水50mL，蒸馏余酸，再加入水50mL，氨水调节PH=2.5。冷却至室温，经过滤，滤渣烘干得未反应2-甲基-5-硝基咪唑12.4g。滤液用活性炭脱色后，加入氨水调PH=6-7，过滤、洗涤、干燥得产品29.3g(熔点138-140℃)，产率70.3%。总产率54.3%.
TCI Shanghai:1,2-二甲基-5-硝基咪唑 1,2-Dimethyl-5-nitroimidazole,>;97.0%(T)(551-92-8)