Mefenamic Acid 甲芬那酸
CAS 61-68-7 MFCD00051721
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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分类
- {SNA} Analytical Standards, Chromatography, EP Standards, EP Standards L - M, Pharmaceutical Standards, Pharmacopeia Standards, 分析/色谱
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cell Signaling and Neuroscience, Drug Efflux Pumps, Drug Transport Compounds, Drug Transport Proteins & Reagents, M, Membrane Protein Biology Tools, Modulators for MRP Transporters, Multi-Drug Resistance, Multi-Drug Resistance and Drug Metabolism, Proteins and Derivatives, Shionogi, 细胞生物学
- {SNA} Analytical Standards, EP Standards, EP Standards L - M,
- {SNA} Approved Thera
安全信息
GHS Symbol
- H302 Harmful if swallowed 吞食有害
- R22 Harmful if swallowed 吞咽有害
- S36 Wear suitable protective clothing 穿戴适当的防护服;
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P263 Avoid contact during pregnancy/while nursing. 怀孕/哺乳期间避免接触。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P312
- P301+P312+P330
- P308+P311
- P330 Rinse mouth. 漱口
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 327 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971
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TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 96 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 89,1392,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 740 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory stimulation REFERENCE : TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143, Japan) V.1- 1954- Volume(issue)/page/year: 28,99,1981
TYPE OF TEST : LD50 - L
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 525 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JNPHAG Journal de Pharmacologie. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1970- Volume(issue)/page/year: 2,259,1971
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE : 10 mg/kg SEX/DURATION : female 21 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 27,117,1984
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE : 8 mg/kg SEX/DURATION : female 13 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) REFERENCE : JCGBDF Journal of Craniofacial Genetics and Developmental Biology. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 10,83,1990
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE : 30 mg/kg SEX/DURATION : female 2 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - menstrual cycle changes or disorders REFERENCE : JRPMAP Journal of Reproductive Medicine. (2 Jacklynn Ct., St. Louis, MO 63132) V.3- 1969- Volume(issue)/page/year: 28,592,1983
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE : 8 mg/kg SEX/DURATION : female 13 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) REFERENCE : JCGBDF Journal of Craniofacia
其他信息
- MSDS 信息:2-[(2,3-Dimethylphenyl)amino]benzoic acid(61-68-7).msds
- 用途一:用于甾体抗炎镇痛药,适用于关节痛、头痛、脚痛、牙病以及其他炎症性疼痛
- 甲灭酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 M1782 甲芬那酸 Mefenamic Acid 500G 2330元 2014/06/02 M1782 甲芬那酸 Mefenamic Acid 25G 259元
- 用途二:用作消炎镇痛药
- 上游原料:2,3-二甲基苯胺
- 图谱信息:甲灭酸(61-68-7)红外图谱(IR1) 甲灭酸(61-68-7)质谱(MS)
- 用途三:用于甾体抗炎镇痛药,适用于关节痛、头痛、脚痛、牙病以及其它炎症性疼痛。
- 甲灭酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 M1782 甲芬那酸 Mefenamic Acid 500G 3370元 2011/04/16 M1782 甲芬那酸 Mefenamic Acid 25G 400元
- 概述:甲灭酸(Mefenamic acid)又称为甲芬那酸、扑湿痛,化学名称为N-(2,3-二甲苯基)-2-氨基苯甲酸,常温下为白色结晶或结晶性粉末,无臭,在水中不溶,在乙醇、氯仿中微溶,在乙醚中略溶。熔点230-231℃,是一种消炎镇痛药,具有解热、镇痛和抗炎作用。镇痛作用较强,解热持久,但消炎作用不及保泰松和氟芬那酸。作用机制是通过抑制前列腺素合成,抑制蛋白质分解酶,稳定细胞膜的蛋白质结构,干扰组织代谢过程而发挥作用。用于风湿性、类风湿性关节炎及头痛、牙痛、神经痛、月经痛、分娩后疼痛、骨盆痛的治疗等。
- Sigma Aldrich:61-68-7(sigmaaldrich)
- TCI Shanghai:甲芬那酸 Mefenamic Acid,>;98.0%(T)(61-68-7)
- MOL 文件:61-68-7.mol