Mefenamic Acid 甲芬那酸

CAS 61-68-7 MFCD00051721

化学结构图

61-68-7
SMILES:

化学属性

Mol. FormulaC15H15NO2
Mol. Weight241
TSCANo
Melting Point230 °C

别名和识别编码

Chemical NameMefenamic Acid
CAS Number61-68-7
Alfabeta NameDIMETHYLPHENYLAMINOBENZOICACID 223(())--,
MDL NumberMFCD00051721
Synonym 抗炎止痛灵 N-(2,3-Xylyl)anthranilic acid 2-(2,3-Dimethylanilino)benzoic aci 2-((2,3-Dimethylphenyl)amino)benzoic acid 2-(2,3-XYLIDINO)BENZOIC ACID 甲灭酸 2’,3’-dimethyl-2-diphenylaminecarboxylicaci 氨水 Ponstan forte Po acidemefenamique Anthranilic acid, N-2,3-xylyl- Ponstan LABOTEST-BB LT00134660 2-[(2,3-Dimethylphenyl)amino]benzoic acid; N-(2,3-Xylyl)anthranilic acid N-[(2,3-DIMETHYLPHENYL)AMINO]BENZOIC ACID Bafameritin-M N-(2,3-Xylyl)-2-aminobenzoic acid Mefenamic acid 2-[(2,3-Dimethylphenyl)amino]benzoic acid Benzoic acid, 2-((2,3-dimethylphenyl)amino)- 2-Diphenylaminecarboxylic acid, 2',3'-dimethyl- 扑湿痛 N-(2,3-二甲苯基)-邻氨基苯甲酸 甲芬那酸 Mephenamic acid N-(2,3-DIMETHYLPHENYL)ANTHRANILIC ACID Mefenaminsaeure Vialidon Ponstil Lysalgo AGN-1255 ac.mefenamico Tanston N-(2,3-Dimethylphenyl)anthranilic acid 2-[(2,3-Dimethylphenyl)amino]benzoic acid N-(2,3-Xylyl)anthranilic acid Bonabol Bafhameritin-M N-(2,3-二甲苯基)-2-氨基苯甲酸 METHENAMIC ACID 2-[(2,3-DIMETHYLPHENYL)AMINO]BENZOIC ACID 甲灭酸(扑湿痛) {Chemic Ponstel Acide mefenamique Coslan MEFENAMIC ACID Pontal Ponalar 2-((2,3-dimethyl(phenyl)amino)-benzoicaci INF 3355 Mephenaminic acid CN-35355 CI-473 Parkemed Ac. mefenamico n-(2,3-xylyl)anthranilic acid
PubChem Substance ID87558870
EC Number200-513-1
Merck Number5798
Reaxys-RN2216243
Chemical Name Translation甲芬那酸
Wiswesser Line NotationQVR BMR B1 C1
Beilstein Registry Number2216243
LabNetwork Molecule IDLN00175775
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分类

  • {SNA} Analytical Standards, Chromatography, EP Standards, EP Standards L - M, Pharmaceutical Standards, Pharmacopeia Standards, 分析/色谱
  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cell Signaling and Neuroscience, Drug Efflux Pumps, Drug Transport Compounds, Drug Transport Proteins & Reagents, M, Membrane Protein Biology Tools, Modulators for MRP Transporters, Multi-Drug Resistance, Multi-Drug Resistance and Drug Metabolism, Proteins and Derivatives, Shionogi, 细胞生物学
  • {SNA} Analytical Standards, EP Standards, EP Standards L - M,
  • {SNA} Approved Thera

安全信息

Warnings IRRITANT
WGK Germany3
GHS Symbol
Hazard statements
  • H302 Harmful if swallowed 吞食有害
RTECSCB4550000
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes 6.1 Xn
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P263 Avoid contact during pregnancy/while nursing. 怀孕/哺乳期间避免接触。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P301+P312+P330
  • P308+P311
  • P330 Rinse mouth. 漱口
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 327 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   18,185,1971

{

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 96 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKKZAJ Yakugaku Zasshi.  Journal of Pharmacy.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  No.1-    1881-
   Volume(issue)/page/year: 89,1392,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 740 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   TOIZAG Toho Igakkai Zasshi.  Journal of Medical Society of Toho University.
   (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,
   Japan)  V.1-    1954-  Volume(issue)/page/year: 28,99,1981

TYPE OF TEST            : LD50 - L

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 525 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JNPHAG Journal de Pharmacologie.  (SPPIF, B.P.22, F-41353 Vineuil, France)
   V.1-    1970-  Volume(issue)/page/year: 2,259,1971

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 10 mg/kg
SEX/DURATION            : female 21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - cardiovascular
   (circulatory) system
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 27,117,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 8 mg/kg
SEX/DURATION            : female 13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   JCGBDF Journal of Craniofacial Genetics and Developmental Biology.  (Alan R.
   Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1980-
   Volume(issue)/page/year: 10,83,1990

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 30 mg/kg
SEX/DURATION            : female 2 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
   JRPMAP Journal of Reproductive Medicine.  (2 Jacklynn Ct., St. Louis, MO
   63132)  V.3-    1969-  Volume(issue)/page/year: 28,592,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 8 mg/kg
SEX/DURATION            : female 13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   JCGBDF Journal of Craniofacia

UN Number 3011
Packing GroupIII

其他信息

  • MSDS 信息:2-[(2,3-Dimethylphenyl)amino]benzoic acid(61-68-7).msds
  • 用途一:用于甾体抗炎镇痛药,适用于关节痛、头痛、脚痛、牙病以及其他炎症性疼痛
  • 甲灭酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 M1782 甲芬那酸 Mefenamic Acid 500G 2330元 2014/06/02 M1782 甲芬那酸 Mefenamic Acid 25G 259元
  • 用途二:用作消炎镇痛药
  • 上游原料:2,3-二甲基苯胺
  • 图谱信息:甲灭酸(61-68-7)红外图谱(IR1) 甲灭酸(61-68-7)质谱(MS)
  • 用途三:用于甾体抗炎镇痛药,适用于关节痛、头痛、脚痛、牙病以及其它炎症性疼痛。
  • 甲灭酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 M1782 甲芬那酸 Mefenamic Acid 500G 3370元 2011/04/16 M1782 甲芬那酸 Mefenamic Acid 25G 400元
  • 概述:甲灭酸(Mefenamic acid)又称为甲芬那酸、扑湿痛,化学名称为N-(2,3-二甲苯基)-2-氨基苯甲酸,常温下为白色结晶或结晶性粉末,无臭,在水中不溶,在乙醇、氯仿中微溶,在乙醚中略溶。熔点230-231℃,是一种消炎镇痛药,具有解热、镇痛和抗炎作用。镇痛作用较强,解热持久,但消炎作用不及保泰松和氟芬那酸。作用机制是通过抑制前列腺素合成,抑制蛋白质分解酶,稳定细胞膜的蛋白质结构,干扰组织代谢过程而发挥作用。用于风湿性、类风湿性关节炎及头痛、牙痛、神经痛、月经痛、分娩后疼痛、骨盆痛的治疗等。
  • Sigma Aldrich:61-68-7(sigmaaldrich)
  • TCI Shanghai:甲芬那酸 Mefenamic Acid,>;98.0%(T)(61-68-7)
  • MOL 文件:61-68-7.mol

系列性分类


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