CAS 58-93-5 MFCD00051765-6-Chloro-3,4-Dihydro-(2H)-1,2,4-Benzothiadiazine-7-Sulfonamide 1,1-Dioxide 6-氯-7-磺酰胺-3,4-二氢-1,2,4-苯并噻二嗪-1,1-二氧化物 TAO{mole}

6-Chloro-3,4-Dihydro-(2H)-1,2,4-Benzothiadiazine-7-Sulfonamide 1,1-Dioxide 6-氯-7-磺酰胺-3,4-二氢-1,2,4-苯并噻二嗪-1,1-二氧化物

CAS 58-93-5 MFCD00051765

化学结构图

SMILES: NS(=O)(=O)c1cc2c(cc1Cl)NCNS2(=O)=O

化学属性

Mol. Formula	C7H8ClN3O4S2
Mol. Weight	297.74
Density	1.422
Melting Point	266-272°
TSCA	Yes
Appearance	白色结晶性粉末。溶点273-275℃，溶于丙酮，微溶于醇，不溶于水、氯仿、乙醚，溶于氢氧化钠溶液，但易水解。味微苦。

别名和识别编码

Chemical Name	6-Chloro-3,4-Dihydro-(2H)-1,2,4-Benzothiadiazine-7-Sulfonamide 1,1-Dioxide
CAS Number	58-93-5
Synonym	Hydrodiuretic 6-ch 6-Chlor 6-氯-3, Disalunil Esidrix Maschitt Servithiazid 3,4-dihydro Hypothiazid 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonami Hyp 双氢氯噻嗪 6-氯-7-磺酰胺-3,4-二氢-1,2,4-苯并噻二嗪-1,1-二氧化物 {Chemica 6-Chloro-3,4-dihydro-7-sulphamoyl-1,2,4-ben-zoth-iadi-azine1,1-dioxcide Dichlot Hydrothide Thiaretic 6-Chloro-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benz Su 5879 氢氯噻嗪 Hydril 6-氯-3,4-二氢-2H-1,2,4-苯并噻二嗪-7-磺酰胺-1,1-二氧化物 Direma {uni_ha 氢氯噻嗪, 98% Hidril Fluvin 6-CHLORO-7-SULFAMYL-3,4-DIHYDRO-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE 双氢克尿塞/二氢氯噻 Idrotiazide {h 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-Dioxide 二氢氯噻 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-, 1,1-dioxide 6-Chloro-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide Hydro-Diuril Ivaugan {C 3,4-Dihydrochlorothiazide 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide Bremil Dihydrochloruri {uni_hambur Acuretic Nefrix Chlorosulthiadil Dyazide {un Aquarius Hypothiazide {haz HCZ Dihydrochlorothiazide Oretic Drenol 6-chloro-3,4-dih Hydro-Aquil Dihydrochlorothiazidum Dihydroxychlorothiazi
MDL Number	MFCD00051765
PubChem Substance ID	3639
EC Number	200-403-3
Beilstein Registry Number	0625101
Merck Number	14,4781
Chemical Name Translation	6-氯-7-磺酰胺-3,4-二氢-1,2,4-苯并噻二嗪-1,1-二氧化物
Wiswesser Line Notation	T66 BSWM EM DHJ HG ISZW
LabNetwork Molecule ID	LN00221313
InChI	InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)

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品牌质保精细包装现货库存一流品牌服务

产品应用

A carbonic anhydrase inhibitor. Diuretic.

安全信息

WGK Germany2

GHS Symbol

Signal word Warning

Hazard statements

H302 Harmful if swallowed 吞食有害

RTECSDK9100000

Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

Safety Statements

S7 Keep container tightly closed 保存在严格密闭容器中；
S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
S33 Take precautionary measures against static discharges 对静电采取预防措施；
S22 Do not breathe dust 不要吸入粉尘；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S24 Avoid contact with skin 避免皮肤接触；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；

Risk Statements

R42/43
R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
R22 Harmful if swallowed 吞咽有害
R23/25 Toxic by inhalation and if swallowed 吸入及吞食都有毒
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338

Hazard Codes Xn Xi,T,F

Storage condition 2-8°C

UN Number UN 1230 3/PG 2

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 309 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-357,1989

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 590 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 134,273,1961

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes,
   C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973
   Volume(issue)/page/year: -,124,1973

{h

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FRZKAP Farmatsevtichnii Zhurnal (Kiev).  (V/O Mezhdunarodnaya Kniga, 113095
   Moscow, USSR) V.3-    1930-  Volume(issue)/page/year: (5),26,1983

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1470 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes,
   C.D., and L.G. Eltherington, Berkeley, Univ. of California Pre

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Mold - Aspergillus nidulans
DOSE/DURATION           : 1 gm/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 26,159,1974

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 5 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 89,95,1981

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 500 mg/L
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-357,1989

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 500 mg/L/48H
REFERENCE :
   GMCRDC Gann Monograph on Cancer Research.  (Plenum Pub. Corp., 233 Spring
   St., New York, NY 10013) No. 11-    1971-  Volume(issue)/page/year:
   27,95,1981

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 43 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   10(Suppl 10),1,1987

其他信息

储运特性:库房低温, 通风, 干燥
图谱信息:双氢氯噻嗪(58-93-5)红外图谱(IR1) 双氢氯噻嗪(58-93-5)红外图谱(IR2)
Acros Organics:6-Chloro-1,1-dioxo-1,2,3,4-tetrahydro-1lambda~6~,2,4-benzothiadiazine-7-sulfonamide, 97%(58-93-5)
急性毒性:口服- 大鼠 LD50: 2750 毫克/ 公斤; 口服-小鼠 LD50: 1175 毫克/公斤
MSDS 信息:Hydrochlorothiazide(58-93-5).msds
毒性分级:中毒
上游原料:3-氯苯胺 --> 4,4'-二氨基苯酰替苯胺
Alfa Aesar:氢氯噻嗪,98% Hydrochlorothiazide, 98%(58-93-5)
方法一:由间氯苯胺经氯磺化得到5-氯-2，4-氯磺酰苯胺，再氨反应生成5-氯-2，4-氨磺苯胺，最后用甲醛歪合制得。
双氢氯噻嗪价格(试剂级):更新日期产品编号产品名称包装价格 2010/06/21 JFD00715EA 双氢氯噻嗪 6-chloro-1,1-dioxo-1,2,3,4-tetrahydro-1lambda~6~,2,4-benzothiadiazine-7-sulfonamide 10 GR 480元 2010/06/21 JFD00715EB 双氢氯噻嗪 6-chloro-1,1-dioxo-1,2,3,4-tetrahydro-1lambda~6~,2,4-benzothiadiazine-7-sulfonamide 25 GR 900元 2010/05/25 B22093 氢氯噻嗪, 98% Hydrochlorothiazide, 98% 25g 955元
Hazard Note:Irritant
Sigma Aldrich:58-93-5(sigmaaldrich)
可燃性危险特性:可燃; 火场分解有毒氯化氢，硫氧化物, 氮氧化物气体
灭火剂:水, 二氧化碳, 干粉, 砂土
类别:有毒物质
用途一:该品为噻嗪类中效利尿药的典型代表，在美国1985年药物销售额排第一位。因服用方便，作用中等，且适用于各种水肿，因此是临床上最常因有排钾性不良反应，应用时需补充钾盐。小鼠静永注射LD50为590mg/kg，口服LD50为大于8000mg/kg。
MOL 文件:58-93-5.mol