Sodium 1-((4-((2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-yl)Methyl)Cyclohexanecarbonyl)Oxy)-2,5-DioxoPyrrolidine-3-Sulfonate 4-(N-马来酰亚胺甲基)环己烷-1-羧酸磺酸基琥珀酰亚胺酯钠盐
CAS 92921-24-9 MFCD00054978
化学结构图
SMILES: [Na+].[O-]S(=O)(=O)C1CC(=O)N(OC(=O)C2CCC(CN3C(=O)C=CC3=O)CC2)C1=O
化学属性
| Mol. Formula | C16H17N2NaO9S |
|---|---|
| Mol. Weight | 436 |
| TSCA | No |
别名和识别编码
| Chemical Name | Sodium 1-((4-((2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-yl)Methyl)Cyclohexanecarbonyl)Oxy)-2,5-DioxoPyrrolidine-3-Sulfonate |
|---|---|
| CAS Number | 92921-24-9 |
| Synonym | 4-(N-马来酰亚胺甲基)环己烷-1-羧酸 3-磺酸基-N-羟基琥珀酰亚胺酯钠盐 4-[(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]cyclohexanecarboxylic Acid 2,5-Dioxo-3-sulfo-1-pyrrolidinyl Ester, Sodium Salt Sulfo-SMCC Sulfo-SMCC,4-(N-Maleimidomethyl)cyclohexane-1-carboxylic acid 3-sulfo-N-hydroxysuccinimide ester sodium salt |
| MDL Number | MFCD00054978 |
| PubChem Substance ID | 160871274 |
| Chemical Name Translation | 4-(N-马来酰亚胺甲基)环己烷-1-羧酸磺酸基琥珀酰亚胺酯钠盐 |
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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现货库存
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分类
- {SNA} Chemical Biology, Chemical Synthesis, Crosslinkers, Crosslinking, Heterobifunctional Cross-Linking Reagents,
- Chemical Biology, Chemical Synthesis, Crosslinkers, Crosslinking, Heterobifunctional Cross-Linking Reagents, Linkers and Crosslinkers, Protein Modification, Protein Structural Analysis, Proteomics
- {SNA} Amine to Sulfhydryl, Chemical Biology, Chemical Synthesis, Crosslinkers, Crosslinking, Heterobifunctional Cross-Linking Reagents, Linkers and Crosslinkers, Protein Modification, 分子生物学, 蛋白质组学, 蛋白质结构分析
产品应用
- Water soluble, heterobifunctional cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity. Typically, coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). Second coupling specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates. Contains 9 atom linker. An extended aliphatic spacer stabilizes the maleimide prior to coupling compared to aromatic spacers.
相关文献及参考
- Maham, D.G., et al.: Anal. Biochem., 162, 163 (1987),
- Yoshitake, S., et al.: Eur. J. Biochem., 101, 395 (1979),
- Hashida, S., et al.: J. Applied Biochem., 6, 56 (1984),
- Hashida, S., et al., More useful maleimide compounds for the conjugation of Fab' to horseradish peroxidase through thiol groups in the hinge. J. Appl. Biochem. 6 , 56-63, (1984) 摘要
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P302+P350
- P305+P351+P338
- P305+P351+P338+P337+P313
- P332+P313
- P337+P313
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S37 Wear suitable gloves 戴适当手套；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
- R20/21 Harmful by inhalation and in contact with skin 吸入及与皮肤接触有害
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
