Baclofen 巴氯芬
CAS 1134-47-0 MFCD00055143
信息真实价格透明
资金保障
专业采购外包团队在线服务
信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- Agonists, B, Bioactive Small Molecules,
- {SNA} Agonists, B, GABAergics, Neuroscience, Neurotransmission, Neurotransmitters, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- {SNA} Agonists, GABAergics, Neuroscience, Neurotransmission, Neurotransmitters, 细胞信号转导和神经科学, 细胞生物学
- {SNA} Agonists,
- {SNA} Agonists, B, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, GABAergics, Neuroscience, Neurotransmission,
产品应用
- Specific GABA-B receptor agonist. Muscle relaxant (skeletal).
相关文献及参考
- Ahuja, S., et al.: Anal. Profiles Drug Subs., 14, 527 (1985),
- Merck 14 ,937
安全信息
GHS Symbol
- H301 Toxic if swallowed 吞食有毒
- H315 Causes skin irritation 会刺激皮肤
- H317 May cause an allergic skin reaction 可能导致皮肤过敏
- H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H319 Causes serious eye irritation 严重刺激眼睛
- H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P301+P310
- P308+P313
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P305+P351+P338
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- P302+P352+P333+P313+P362+P364
- P302+P350
- P337+P313
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P284 Wear respiratory protection.? 佩戴呼吸保护装置。
- P342+P311
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
- P285 In case of inadequate ventilation wear respiratory protection. 在通风不足的情况下,戴呼吸防护。
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- S22 Do not breathe dust 不要吸入粉尘;
- S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S36 Wear suitable protective clothing 穿戴适当的防护服;
- S52 Not recommended for interior use on large surface areas 建议不在表面积大的区域内部使用;
- R42/43
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
- R25 Toxic if swallowed 吞咽有毒
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,576,1982
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 3429 mg/kg TOXIC EFFECTS : Behavioral - coma Cardiac - pulse rate increase, without fall in
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 78 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 11,181,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 145 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,576,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 115 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, T
其他信息
- 储运特性:通风低温干燥; 与库房食品原料分开存放
- color:white to very faintly yellow
- 毒性分级:高毒
- EPA Substance Registry System:1134-47-0(EPA Substance)
- 急性毒性:口服-大鼠 LD50; 145 毫克/公斤; 口服-小鼠 LD50: 200 毫克/公斤
- 药物作用:巴氯芬(1134-47-0)为解痉药,是γ-氨基丁酸(GABA)的衍生物,为作用于脊髓的骨骼肌松驰剂、镇静剂。 巴氯芬(1134-47-0)用于缓解由以下疾病引起的骨骼肌痉挛:多发性硬化、脊髓空洞症、脊髓肿瘤、横贯性脊髓炎、脊髓外伤和运动神经元病、脑血管病、脑性瘫痪、脑膜炎、颅脑外伤。
- 巴氯芬价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 B3343 巴氯芬 Baclofen 5G 1420元 2014/06/02 B3343 巴氯芬 Baclofen 25G 5010元
- 上游原料:氯苯 --> 4-氯苯甲醛 --> 乙酰氧基乙酸 --> 戊二酸 --> 戌二酸酐 --> 二乙酰乙酸乙酯
- 可燃性危险特性:可燃; 燃烧产生有毒氮氧化物和氯化物烟雾; 患者服用副作用:血压低,脉搏降低,肌肉无力
- MOL 文件:1134-47-0.mol
- 灭火剂:干粉,泡沫,沙土,二氧化碳, 雾状水
- 类别:有毒物品
- 方法一:将对氯苯甲醛与乙酰乙酸乙酯缩合生成对氯代苯亚甲基-双-乙酰乙酸乙酯。加热水水解得对氯代苯基戊二酸。用乙酐脱水环合生成对氯代苯基戊二酸酐。再用浓氨水胺化生成对氯代苯基戊二酸亚酰胺,最后开环、降解得对氯苯氨酪酸。其最后开环、降解的具体操作方法如下:将42.25gβ-(对氯苯基)戊二酸亚酰胺在搅拌下加入到含8.32g氢氧化钠的200ml水溶液中。混合物于50℃加热10min,冷却至10-15℃,滴加含40.9g氢氧化钠的200ml水溶液,20min后,加38.8g溴,在20-25℃搅拌8h,用浓盐酸仔细地将反应液的pH值调至7,随后即沉降出细的β-(对氯苯基)-γ-氨基-丁酸结晶,再由水中重结晶,熔点206-208℃。
- 用途一:该品系作用于脊椎的骨骼肌松驰剂,镇痉剂。适用于多发性硬化的骨骼股痉挛症;脊髓感染,变性的肌肉痉挛症;脊髓外伤性、赘生性肌肉痉挛症。
- 外观:白色晶体粉末.