CAS 31677-93-7 MFCD00055209-Bupropion hydrochloride 盐酸安非他酮(精神管制药品，不能销售） TAO{mole}

Bupropion hydrochloride 盐酸安非他酮(精神管制药品，不能销售）

CAS 31677-93-7 MFCD00055209

化学结构图

SMILES: Cl.CC(NC(C)(C)C)C(=O)C1C=CC=C(Cl)C=1

化学属性

Mol. Formula	C13H19Cl2NO
Mol. Weight	276
TSCA	No
Melting Point	222

别名和识别编码

Chemical Name	Bupropion hydrochloride
CAS Number	31677-93-7
Alfabeta Name	BUPROPIONHYDROCHLORIDE
MDL Number	MFCD00055209
Synonym	2-(tert-Butylamino)-1-(3-chlorophenyl)-1-propanone Hydrochloride, Amfebutamone Hydrochloride Bupropion hydrochloride
PubChem Substance ID	125307968
EC Number	250-759-9
Merck Number	1499
Chemical Name Translation	盐酸安非他酮(精神管制药品，不能销售）
Reaxys-RN	6161273
Beilstein Registry Number	6161273

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分类

{SNA} Approved Therapeutics/Drug Candidates, B, Bioactive Small Molecules, Biochemicals and Reagents, Biogenic Amine Transport Inhibitors, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, GlaxoSmithKline, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmission (Obesity), Neurotransmitters, Obesity Research, Proteins and Derivatives
{SNA} Analytical Standards, Pharmacopeia & Metrological Institutes Standards, USP Standards, USP Standards A - B, 分析/色谱

安全信息

Warnings IRRITANT

GHS Symbol

Hazard statements

H302 Harmful if swallowed 吞食有害

WGK Germany3

Signal word Warning

RTECSUG8858000

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；

Risk Statements

R22 Harmful if swallowed 吞咽有害

Precautionary statements

P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P301+P312+P330

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 329 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Cardiac - pulse rate
   Cardiac - other changes
REFERENCE :
   JTCTDW Journal of Toxicology, Clinical Toxicology.  (Marcel Dekker, 270
   Madison Ave., New York, NY 10016)  V.19-    1982-  Volume(issue)/page/year:
   35,321,1997

TYPE OF TEST            : LD50 - Lethal dose, 50 perce

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 210 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - muscle contraction or spasticity
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 29,767,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 230 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - changes in motor activity (specific assay)
   Behavioral - analgesia
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 29,767,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 2 mg/kg
TOXIC EFFECTS :
   Behavioral - hallucinations, distorted perceptions
   Behavioral - food intake (animal)
   Gastrointestinal - nausea or vomiting
REFERENCE :
   AJPSAO American Journal of Psyc