CAS 1918-00-9 MFCD00055283-3,6-Dichloro-2-Methoxybenzoic Acid 3,6-二氯-2-甲氧基苯甲酸 TAO{mole}

3,6-Dichloro-2-Methoxybenzoic Acid 3,6-二氯-2-甲氧基苯甲酸

CAS 1918-00-9 MFCD00055283

化学结构图

SMILES: COc1c(Cl)ccc(Cl)c1C(=O)O

化学属性

Mol. Formula	C8H6Cl2O3
Mol. Weight	221.04
Melting Point	112-116°C
Density	1.57
Solubility	50 G/100 ML
Flash Point	2 °C
Boiling Point	316.96 °C at 760 mmHg

别名和识别编码

Chemical Name	3,6-Dichloro-2-Methoxybenzoic Acid
Synonym	Dicamba {LY} Dicamba {} {LY} Dicamba {} {} {LY} Dicamba {} {} {} {LY} Dicamba {} {} {} {} {LY} Dicamba {} {} {} {} {} {LY} Dicamba {} {} {} {} {} {} {LY} Dicamba {} {} {} {} {} {} {} {LY} Dicamba {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Dicamba {} {} {} {} {} {} {} {} {} {LY} Dicamba {} {} {} {} {} {} {} {} {} {} {LY} Dicamba {} {} {} {} {} {} {} {} {} {} {} {LY} Dicamba {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} Dicamba {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Dicamba {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Dicamba {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Dicamba {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Dicamba {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Dicamba
Beilstein Registry Number	2453039
PubChem Substance ID	24893833
CAS Number	1918-00-9
EC Number	217-635-6
MDL Number	MFCD00055283
Chemical Name Translation	3,6-二氯-2-甲氧基苯甲酸
Merck Number	13,3065
Wiswesser Line Notation	QVR BG EG FO1
Canonical SMILES	O=C(C1=C(C=CC(Cl)=C1OC)Cl)O

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品牌质保精细包装现货库存一流品牌服务

产品应用

叶面或土壤除草剂，通过植株叶和根的传导。用于防除芦笋、玉米、高粱、小麦、甘蔗等作物田中一年生和多年生阔叶杂草，也用于防除耕作区的木本灌木丛。通常单用或几个苯氧羧酸类除草剂混用，也可与其他类型的除草剂混用。

安全信息

Precautionary statements

P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P305+P351+P338

RTECSDG7525000

GHS Symbol

Signal word Danger

Hazard statements

H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
H318 Causes serious eye damage 严重伤害眼睛
H302 Harmful if swallowed 吞食有害

Hazard Codes Xn;N Xn Xn,N,F

WGK Germany2

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；

Risk Statements

R52/53
R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
R22 Harmful if swallowed 吞咽有害
R11 Highly flammable 非常易燃
R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
R36 Irritating to eyes 刺激眼睛

UN Number UN 3077 9/PG 3 3077

Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 700 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TGANAK Tsitologiya i Genetika.  Cytology and Genetics.  For English
   translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-    1967-  Volume(issue)/page/year: 16(1),45,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   WRPCA2 World Review of Pest Control.  (London, UK)  V.1-10, 1962-71.
   Discontinued.  Volume(issue)/page/year: 9,119,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag
   New York, Inc., 1971  Volume(issue)/page/year: -,147,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HYSAAV Hygiene and Sanitation (USSR).  English translation of GISAAA.
   (Springfield, VA)  1964-71. Discontinued.  Volume(issue)/page/year:
   35(7-9),14,1970

{haza

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 5 mg/disc
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB80-133226

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 5 mg/disc
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB80-133226

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Unreported
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 500 mg/kg
REFERENCE :
   TGANAK Tsitologiya i Genetika.  Cytology and Genetics.  For English
   translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-    1967-  Volume(issue)/page/year: 16(1),45,1982

TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 17800 ug/kg
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   15,131,1990

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Lymphocyte
DOSE/DURATION           : 200 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   15,131,1990

其他信息

急性毒性:口服-大鼠 LD50: 1039 毫克/公斤; 口服-小鼠 LD50: 1190 毫克/公斤
灭火剂:砂土、干粉、泡沫
储运特性:库房通风低温干燥; 与食品原料分开储运
MOL 文件:1918-00-9.mol
类别:农药
Sigma Aldrich:1918-00-9(sigmaaldrich)
上游原料:氢氧化钠 --> 盐酸 --> 氢氧化钾 --> 二氧化碳 --> 氯甲烷 --> 氯化钴 --> 2,5-二氯苯酚 --> 3,5-二氯苯甲酸 --> 氯苯甲醇
方法一:由1，2，4-三氯苯与CH3OH/NaOH反应制得2，5-二氯苯酚。然后在一定压力下与CO2反应生成2-羟基-3，6-二氯苯甲酸，再与（CH3）2SO4反应合成麦草畏。
毒性分级:中毒
MSDS 信息:3,6-二氯-2-甲氧基苯甲酸(1918-00-9).msds
外观性质:白色晶体。
急救治疗:尚无特效解毒剂。若摄入量大，病人十分清醒，可用吐根糖浆诱吐，还可在服用的活性炭泥中加入山梨醇。
注意事项:[1]小麦三叶前和拔节后禁止使用 [2]麦草畏主要通过茎叶吸收，故此药不宜作土壤处理 [3]药剂正常使用后对小麦、玉米苗在初期有匍匐、倾斜或弯曲现象，一周后方可恢复。 [4]不同小麦品种对此药有不同的敏感反应，应用前要进行敏感性测定
可燃性危险特性:明火可燃; 受热分解有毒氯化物气体
中毒症状:消化道症状严重时对肝、肾损伤。
方法二:以1,2,4-三氯苯、甲醇、二氯化碳和硫酸二甲酯为主要原料而制得。
职业标准:STEL 1 毫克/立方米
用途三:用作植物发芽后的除草剂。常与一种或多种苯氧羧酸类除草剂或其他除草剂混合加工成混剂，用于谷物地除草。
用途二:安息香酸系除草剂（苯甲酸类）。具有内吸传导作用，对一年生和多年生阔叶杂草有显著防效。用于小麦、玉米、谷子、水稻等禾本科作物防除猪殃殃、荞麦蔓、藜、牛繁缕、大巢菜、播娘莴、苍耳、薄朔草、田旋花、刺儿菜、问荆、鲤肠等。苗后喷雾，药剂通过杂草的茎、叶、根吸收，通过韧皮部及木质部上下传导，阻碍植物激素的正常活动，从而使其死亡。一般用48%水剂3～4.5mL/100m 2 (有效成分1.44～2g/100m 2 )。由于麦草畏杀草谱较窄，对某些抗性杂划效果不佳。对小麦安全性较小，常与2，4-滴丁酯或2甲4氯胺盐混用。
毒性:原药对大鼠急性经口LD 50 为1879～2740mg/kg，家兔急性经皮LD 50 >2000mg/kg；大鼠急性吸入LC 50 >200mg/kg。对家兔眼睛有刺激和腐蚀作用，对家兔皮肤有中等刺激。家兔亚急性经皮无作用剂量500mg/kg，大鼠2年饲喂试验无作用剂量为每天25mg/kg，狗为1.25mg/kg。试验条件下未见致畸、致癌、致突变作用。虹鳟鱼LC 50 28mg/L，青鳃翻车鱼23mg/L(均96h)。
用途一:对小麦、玉米等作物中的一季生和多季生阔叶杂草有显著效果