CAS 122-14-5 MFCD00055407-Fenitrothion 杀螟硫磷 TAO{mole}

Fenitrothion 杀螟硫磷

CAS 122-14-5 MFCD00055407

化学结构图

SMILES: COP(=S)(OC)Oc1ccc([N+](=O)[O-])c(C)c1

化学属性

Mol. Formula	C9H12NO5PS
Mol. Weight	277.25
Melting Point	3.4 ºC
Boiling Point	140-145°C
Density	1.0
Solubility	0.003 G/100 ML
Flash Point	>100 °C
Refractive index	1.5528
Stability	对光敏感

别名和识别编码

Chemical Name	Fenitrothion
CAS Number	122-14-5
Synonym	FENTRON O, Sumithion {Chem kotion Ol O,O-Dimethyl O-(4-nitro-3-methylphenyl)thiophosphate O,O-二甲基-O-(3-甲基-4-硝基苯基)硫代磷酸酯 Metathionin FENITROTHION {hazard_ O,O-Dimethyl-O-(3-methyl-4-nitrofenyl)-monothiofosfaat ######## 诺毕速灭松 O,O-Dimetil-O-(3-metil-4-nitrofenil) fosforotioato 奎诺三甲基硫磷 Dimethyl CL 47300 CP 47114 O,O-Dimethyl O-(3-methyl-4-nitrophenyl) phosphorothioate; Phosphorothioic acid O,O-dimethyl O-(3-methyl-4-nitrophenyl) ester; Nitrophos; Novathion; Nuvanol; Nuvanol/N-20; Sumithion; Metathionine; Agrothion; Arbogal; Bayer 41831; Cyfen; Cytel; Dybar; Fenitox; Kotion; MEP 8057HC O,O-Dimethyl O-(3-methyl-4-nitrophenyl) thiophosphate O,O-Dimethyl O-(3-methyl-4-nitrop ENT 25,715 杀螟磷速灭松 Agria 1050 Bayer 41831 Owadofos Metathion E 50 富拉硫磷 American cyanamid CL- Ovadofos Metathione 苏米硫磷 Dybar Fo S 112A Metathionine Folithion EC O,O-Dimethyl O-(3-methyl-4-nitrophenyl) phosphorothioate cytel O,O`-二甲基-O-(3-甲基-4-硝基苯基)酯 AC-47300 {C BAY 41831 {h {haz Phenitrothion FOLITHION FARMATHION Fenitrothion 灭蟑百特 O,O-Dimethyl-O-(4-nitro-5-methylphenyl)-thionophosphat Arbogal Novathion 杀螟硫磷 O,O-Dimethy Nuvanol O,O-Dime MEP Fenitrotion 杀螟松,杀螟硫磷 EI 47300
PubChem Substance ID	31200
EC Number	204-524-2
Beilstein Registry Number	1887367
MDL Number	MFCD00055407
Chemical Name Translation	杀螟硫磷
Merck Number	13,4003
Wiswesser Line Notation	WNR B1 DOPS&O1&O1
InChI	InChI=1S/C9H12NO5PS/c1-7-6-8(4-5-9(7)10(11)12)15-16(17,13-2)14-3/h4-6H,1-3H3

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

校准仪器和装置；评价方法；工作标准；质量保证/质量控制；其他。

安全信息

GHS Symbol

WGK Germany3

Hazard statements

H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
H302 Harmful if swallowed 吞食有害

Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

RTECSTG0350000

Precautionary statements

P501 Dispose of contents/container to..… 处理内容物/容器.....
P273 Avoid release to the environment. 避免释放到环境中。

Signal word Warning

Hazard Codes Xn;N Xn;N,N,Xn,T,F Xn,N

Safety Statements

S2 Keep out of the reach of children 避免儿童触及；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S62 If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label where possible 吞食后不要催吐：立即求医并出示该容器或标签；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；

Risk Statements

R11 Highly flammable 非常易燃
R67 Vapours may cause drowsiness and dizziness 蒸汽可能导致嗜睡和昏厥
R65 Harmful: may cause lung damage if swallowed 若吞咽可能伤害肺部器官
R38 Irritating to skin 刺激皮肤
R21/22 Harmful in contact with skin and if swallowed 皮肤接触和不慎吞咽有害
R23 Toxic by inhalation 吸入有毒
R22 Harmful if swallowed 吞咽有害
R50/53

Packing GroupIII

Hazard Class6.1(b)

Storage condition APPROX 4°C 玻璃安瓿瓶包装，冷藏和避光条件下保存。

UN Number 3018

Restrict 剧毒化学品

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - duck
DOSE/DURATION           : 1190 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   47,451,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intracerebral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCBPBS Pesticide Biochemistry and Physiology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.1-    1971-  Volume(issue)/page/year:
   8,302,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2500 mg/kg
TOXIC EFFECTS :
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - true cholinesterase
REFERENCE :
   ABCHA6 Agricultural and Biological Chemistry.  (Maruzen Co. Ltd., POB 5050,
   Tokyo International, Tokyo 100-31, Japan)  V.25-    1961-
   Volume(issue)/page/year: 25,605,1961

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 229 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TOIZAG Toho Igakkai Zasshi.  Journal of Medical Society of Toho University.
   (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,
   Japan)  V.1-    1954-  Volume(issue)/page/year: 25,635,1978

TYPE OF TEST            : LD50

TYPE OF TEST            : Specific locus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 100 ppb
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 260,225,1991

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 40 mg/L
REFERENCE :
   CHYCDW Zhonghua Yufangyixue Zazhi.  Chinese Journal of Preventive Medicine.
   (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep.
   China)  Beginning history not known.  Volume(issue)/page/year: 20,354,1986

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 500 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 116,185,1983

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Leukocyte
DOSE/DURATION           : 40 mg/L
REFERENCE :
   HOEKAN Hokkaidoritsu Eisei Kenkyushoho.  Report of the Hokkaido Institute of
   Public Health.  (Nishi- 12-chome, Kita-19-jo, Kita-ku, Sapporo 060, Japan) 
   No.1-    1951-  Volume(issue)/page/year: 29,33,1979

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Embryo
DOSE/DURATION           : 55400 ug/L
REFERENCE :
   SNSHBT Senshokutai.  Chromosome.  (Sensyokutai Gakkai, Kaokusai Kirisutokyo
   Daigaku, Mitaka, Tokyo-to, Japan)  No.1-    1946-    Adopted new numbering
   in 1976.  Volume(issue)/page/year: (20),574,1980

{hazard_

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 90 mg/kg
SEX/DURATION            : female 7-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - behavioral
   Reproductive - Effects on Newborn - other postnatal measures or effects
REFERENCE :
   NETEEC Neurotoxicology and Teratology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.9-    1987- Volume(issue)/page/year:
   11,321,1989

其他信息

MOL 文件:122-14-5.mol
灭火剂:砂土、干粉、泡沫
{Che
用途四:杀螟松对水稻、大豆、棉花、果树、蔬菜等多种作物害虫均有良
{Chem
毒性分级:高毒
用途:杀螟硫磷对刺吸式口器、咀嚼式口器害虫和钻蛀性害虫均有较好效果。主要以乳油对水喷雾或粉剂喷粉用于水稻、大豆、棉花、蔬菜、果树、茶树、油料作物和林木上，对水稻二化螟特效，也可防治其他鳞翅目幼虫、叶蝉、飞虱、蓟马、蚜虫、介壳虫、甘薯小象甲
外观性质:纯品为淡黄色油状液体，工业品带棕黄色，有轻度蒜臭。
用途:杀螟硫磷对刺吸式口器、咀嚼式口器害虫和钻蛀性害虫均有较好效果。主要以乳油对水喷雾或粉剂喷粉用于水稻、大豆、棉花、蔬菜、果树、茶树、油料作物和林木上，对水稻二化螟特效，也可防治其他鳞翅目幼虫、叶蝉、飞
上游原料:盐酸 --> 甲醇 --> 硝酸 --> 氯化亚铜 --> 间甲酚 --> 二甲基硫 --> 硝酸钠 -->
方法一:4-硝基间甲酚的制备由间甲酚经亚硝化、氧化制得。亚硝化反应是将间甲酚与严硝酸钠水溶液，在15%～20%硫酸中反应，控制温度10～15℃。氧化反应是将严硝基间甲酚用稀硝酸进行氧化，加酸速度先慢后快，反应温度35～38℃，加毕在44～46℃保温3h，经离心水洗，使pH值达3～4,制得4-硝基间甲酚。 O,O-二甲基硫代磷酰氯的制备 O-甲基硫代磷酰二氯的合成速度很快，在醇过量情况下能使反应进行到底，副产氯化氢用负压排除，主要工艺参数：投料比为5：1，反应温度（-5±2）℃，水洗温度（5±5）℃，加水量（水洗）为投料量×0.7，收率95%～98%，含量>;95%。 O，O-二甲硫代磷酰氯的合成需碱性存在时进行。用醇碱法生产时主要工艺参数：投料比为甲基硫代磷酰二氯：甲醇：碱=1：5：1.08，反应温度-4～0℃，终点pHWFHG9.5～10,水洗加水量为投料量×0.7，以甲基硫代磷酰二氯计收率85%～90%，含量95%。文献报道， O，O-二甲基硫代磷酰氯合成可在偶极非质子溶剂中进行；将84g甲基硫代磷酰二氯（0.5mol)、48g甲醇（1.5mol)、60g非质子溶剂混合后，于≤5℃、60～90min内滴加0.55mol30%氢氧化
用途四:杀螟松对水稻、大豆、棉花、果树、蔬菜等多种作物害虫均有良好的防治效果，尤为防治水稻螟虫特效药。如大螟、二化螟、三化螟、稻飞虱、稻叶蝉、蚜虫、红蜘蛛、棉铃虫、大豆食心虫、茶天蠖等，每亩施用50-75g（有效成分），防治效要良好，但杀螨卵效果较小。该品对十字花科蔬菜有时发生药害。
急性毒性:口服-大鼠 LD50: 250 毫克/公斤; 口服-小鼠 LD50: 229 毫克/公斤
储运特性:库房通风低温干燥; 与食品原料分开储运
方法二:由 O,O-二甲基硫代磷酰氯与4-硝基间甲酚（[2581-34-2]）在碱性条件下缩合而得。将甲苯加入缩合反应锅，搅拌下投入4-硝基间甲酚，碳酸钠和氯化亚铜，在95-97℃时投入O,O-二甲基硫代磷酰氯，在90℃以上反应3h，然后过滤，取甲苯层依次用氢氧化钠溶液、水洗涤，减压蒸馏回收甲苯后得杀螟松原油，含量90%。当采用摩尔配比4-销基间甲酚：O,O-二甲基硫代磷酰氯：碳酸钠=1：1.1：1，甲苯用量约为4-硝基间甲酚的3倍（重量），氯化亚铜约为4-硝基间甲酚的2%（重量）时，杀螟松收率95%以上。所得原油有效成分含量优级品不低于93.0%，一级品≥85.0%原料消耗定额：间甲酚550kg/t、硝酸（100%）860kg/t、三氯硫磷（100%）1240kg/t、甲醇600kg/t。
职业标准:TWA 1 毫克/立方米; STEL 1 毫克/立方米
20℃的蒸气压98*10-7kpa）。能与乙醚、乙醇、丙酮、苯、二甲苯、氯仿，四氯化碳，植物油等互溶，微溶于石油醚和煤油，难溶于水，在高温与碱性条件下易分解，铁，锡，铝，铜，铅等金属会促进分解，蒸馏会引起异构化。
急救治疗:[1]用阿托品1～5mg皮下或静脉注射(按中毒轻重而定) [2]用解磷定0.4－1.2g静脉注射(按中毒轻重而定) [3]禁用吗啡、茶硷、吩噻嗪、利血平。 [4]误服立即引吐、洗胃、导泻(清醒时才能引吐)。